NADPH oxidase mediates TNF-α-evoked in vitro brain barrier dysfunction: roles of apoptosis and time

QR Code

NADPH oxidase mediates TNF-α-evoked in vitro brain barrier dysfunction: roles of apoptosis and time

The pro-inflammatory cytokine TNF-α severely perturbs the integrity of the blood–brain barrier (BBB). This study explored the specific roles of NADPH oxidase and associated downstream effectors by using human brain microvascular endothelial cells (HBMECs) and human astrocytes (HAs), the key componen...

Full description

Bibliographic Details
Main Authors:	Abdullah, Zuraidah, Bayraktutan, Ulvi
Format:	Article
Published:	Elsevier 2014
Subjects:	TNF-α; Blood–brain barrier; NADPH oxidase; MMP; Cytoskeleton
Online Access:	https://eprints.nottingham.ac.uk/37978/

Similar Items

Inhibition of TNF-α protects in vitro brain barrier from ischaemic damage
by: Abdullah, Zuraidah, et al.
Published: (2015)

Suppression of PKC-α attenuates TNF-α-evoked cerebral barrier breakdown via regulations of MMP-2 and plasminogen–plasmin system
by: Abdullah, Zuraidah, et al.
Published: (2016)

Increases in intracellular calcium perturb blood–brain barrier via protein kinase C-alpha and apoptosis
by: Rakkar, Kamini, et al.
Published: (2016)

Molecular Characterization and Localization of the NAD(P)H Oxidase Components gp91-phox and p22-phox in Endothelial Cells
by: Bayraktutan, Ulvi, et al.
Published: (2000)

circRNAs as Epigenetic Regulators of Integrity in Blood–Brain Barrier Architecture: Mechanisms and Therapeutic Strategies in Multiple Sclerosis
by: D'Aversa, Elisabetta, et al.
Published: (2024)

Attenuation of urokinase activity during experimental ischaemia protects the cerebral barrier from damage through regulation of matrix metalloproteinase-2 and NAD(P)H oxidase
by: Rakkar, Kamini, et al.
Published: (2014)

Phytocannabinoids, neuroprotection and the blood-brain barrier
by: Stone, Nicole
Published: (2021)

Development, characterisation and translocation of valproic acid-encapsulated nanoemulsion across blood-brain barrier
by: Tan, Suk Fei
Published: (2017)

Blood-Brain Barrier on-a-chip model for the study of drug permeability into the brain
by: Whitehouse, Chloe Ann
Published: (2022)

Restoration of dietary-fat induced blood-brain barrier dysfunction by anti-inflammatory lipid-modulating agents
by: Pallebage-Gamarallage, Menuka, et al.
Published: (2012)

Investigating the role of Adrenomedullin signalling during zebrafish development
by: Parker, Nathan
Published: (2025)

The impacts of endothelial cell senescence on ageing-related blood-brain barrier dysfunction and the potential therapeutic strategies
by: Ya, Jingyuan
Published: (2025)

Long-term probucol therapy continues to suppress markers of neurovascular inflammation in a dietary induced model of cerebral capillary dysfunction
by: Takechi, Ryu, et al.
Published: (2014)

Molecular characterization of NADPH oxidase genes and expression of marbohB1 gene in response to fungal pathogen Fusarium oxysporum f. sp. cubense in banana
by: Chai, Siew Ying
Published: (2019)

A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS)
by: Negm, Ola H., et al.
Published: (2014)

A study of α-Adrenoceptor agonists on porcine nasal and extra-nasal vasculature: insight into decongestant activity
by: Abdulrahman, Aseel
Published: (2019)

Bioenergetic disruption of human micro-vascular endothelial cells by antipsychotics
by: Elmorsy, Ekramy, et al.
Published: (2015)

Post-prandial lipid metabolism, lipid-modulating agents and cerebrovascular integrity: Implications for dementia risk
by: Pallebage-Gamarallage, Menuka, et al.
Published: (2010)

Adverse effects of antipsychotics on micro-vascular endothelial cells of the human blood–brain barrier
by: Elmorsy, Ekramy, et al.
Published: (2014)

Antidepressants are cytotoxic to rat primary blood brain barrier endothelial cells at high therapeutic concentrations
by: Elmorsy, Ekramy, et al.
Published: (2017)

Outgrowth Endothelial Cells (OECs): Cell-Based Therapy, Cell-Free Strategy, and Role of Senescence
by: Kadir, Rais Reskiawan A.
Published: (2022)

Establishment of horse blood-brain barrier model for the study of drug delivery to the brain
by: Gupta, Gaurav
Published: (2025)

Purification and Characterization of Membrane-Bound Polyphenol Oxidases and Peroxidases from Metroxylon Sagu Rottb
by: Hassan Onsa, Galila
Published: (2003)

hShroom1 links a membrane bound protein to the actin cytoskeleton
by: Dye, Danielle, et al.
Published: (2009)

The Blood-Brain Barrier integrity and function in ischaemic injury and multiple sclerosis with role of hypothermia
by: Mathur, Manik
Published: (2016)

Pharmacological treatment and prevention of cerebral small vessel disease: a review of potential interventions
by: Bath, Philip M.W., et al.
Published: (2015)

The role of outgrowth endothelial cells as therapeutics for ischaemic injury-mediated cerebrovascular damage: impact of NOX2 inhibitor
by: Alwjwaj, Mansour
Published: (2022)

The First CNS-Active Carborane: A Novel P2X7 Receptor Antagonist with Antidepressant Activity
by: Wilkinson, S., et al.
Published: (2014)

Alterations of blood-brain barrier functions and gene expression during Toxoplasma gondii infection
by: Harun, Mohammad Syamsul Reza
Published: (2019)

Highlights of children with Cancer UK’s workshop on drug delivery in paediatric brain tumours
by: Nailor, Audrey, et al.
Published: (2016)

Advanced MRI techniques in studying multiple sclerosis pathology and lesion progression
by: Elsarraj, Afaf
Published: (2016)

Vitamins Reverse Endothelial Dysfunction Through Regulation of eNOS and NAD(P)H Oxidase Activities
by: Ulker, Sible, et al.
Published: (2003)

Free radicals, diabetes and endothelial dysfunction
by: Bayraktutan, Ulvi
Published: (2002)

Evaluation of cell-penetrating peptides as tools to improve nose-brain delivery of insulin
by: Brown, Alexander
Published: (2024)

Disruption of blood-brain barrier function by chronic intake of saturated fat and cholesterol : implications for Alzheimer’s disease risk
by: Takechi, Ryusuke
Published: (2010)

Determinants of physical activity participation following traumatic brain injury
by: Reavenall, Sarah, et al.
Published: (2010)

Correlation between in vitro tests for blood brain barrier penetration with in vivo gliclazide penetration
by: Lalic-Popovic, M., et al.
Published: (2013)

Transition metal diphenolate and dithiophenolate complexes as synthetic analogues of the active sites of nickel superoxide dismutase and galactose oxidase
by: Marshall, George
Published: (2016)

The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes
by: Krause, M., et al.
Published: (2015)

Optimization of process parameters in preparing nanoemulsion containing kojic monooleate using response surface methodology and evaluation of tyrosinase inhibition through in vitro and in silico methods
by: Roselan, Muhammad Azimuddin
Published: (2020)