Inhibition of TNF-α protects in vitro brain barrier from ischaemic damage

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Inhibition of TNF-α protects in vitro brain barrier from ischaemic damage

Cerebral ischaemia, associated with neuroinflammation and oxidative stress, is known to perturb blood–brain barrier (BBB) integrity and promote brain oedema formation. Using an in vitro model of human BBB composed of brain microvascular endothelial cells and astrocytes, this study examined whether s...

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Bibliographic Details
Main Authors:	Abdullah, Zuraidah, Rakkar, Kamini, Bath, Philip M.W., Bayraktutan, Ulvi
Format:	Article
Published:	Elsevier 2015
Subjects:	TNF-α; Ischaemic injury; Cerebral barrier; In vitro model of BBB; NADPH oxidase; MMP
Online Access:	https://eprints.nottingham.ac.uk/37977/

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