Attenuation of urokinase activity during experimental ischaemia protects the cerebral barrier from damage through regulation of matrix metalloproteinase-2 and NAD(P)H oxidase

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Attenuation of urokinase activity during experimental ischaemia protects the cerebral barrier from damage through regulation of matrix metalloproteinase-2 and NAD(P)H oxidase

Ischaemic injury impairs the integrity of the blood–brain barrier (BBB). In this study, we investigated the molecular causes of this defect with regard to the putative correlations among NAD(P)H oxidase, plasminogen–plasmin system components, and matrix metalloproteinases. Hence, the activities of N...

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Bibliographic Details
Main Authors:	Rakkar, Kamini, Srivastava, Kirtiman, Bayraktutan, Ulvi
Format:	Article
Published:	Wiley 2014
Subjects:	Reperfusion injury; Superoxide anion; Blood-brain barrier; p22-phox ; Matrix metalloproteinase
Online Access:	https://eprints.nottingham.ac.uk/37974/

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