Hereditary nephropathy in an English Cocker Spaniel
A thirteen-month-old male neutered orange roan English Cocker Spaniel dog was euthanized due to a prolonged history of lethargy, weight loss, severe azotemia and marked proteinuria, which was suggestive of chronic renal failure. At necropsy, both kidneys were pale tan and presented with a diffusely...
| Main Authors: | , , , , , |
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| Format: | Article |
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American Veterinary Medical Association
2015
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| Online Access: | https://eprints.nottingham.ac.uk/37944/ |
| _version_ | 1848795566647017472 |
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| author | de Brot, Simone Adamany, J. Baiker, Kerstin Allegrucci, Cinzia Polledo, L. Grau-Roma, Llorenc |
| author_facet | de Brot, Simone Adamany, J. Baiker, Kerstin Allegrucci, Cinzia Polledo, L. Grau-Roma, Llorenc |
| author_sort | de Brot, Simone |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | A thirteen-month-old male neutered orange roan English Cocker Spaniel dog was euthanized due to a prolonged history of lethargy, weight loss, severe azotemia and marked proteinuria, which was suggestive of chronic renal failure. At necropsy, both kidneys were pale tan and presented with a diffusely rough and granular appearing surface. Histologically, both kidneys showed severe, generalized, segmental to global, chronic membranoproliferative glomerulonephritis with glomerulosclerosis and proteinuria. DNA was extracted from hair follicles collected at necropsy, and a PCR amplifying exon 3 of gene COL4A4 was performed. The PCR showed that this dog had a homozygous mutation at the position 115 of the gene COL4A4, indicating that this dog suffered from hereditary nephropathy. |
| first_indexed | 2025-11-14T19:34:08Z |
| format | Article |
| id | nottingham-37944 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:34:08Z |
| publishDate | 2015 |
| publisher | American Veterinary Medical Association |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-379442020-05-04T17:14:17Z https://eprints.nottingham.ac.uk/37944/ Hereditary nephropathy in an English Cocker Spaniel de Brot, Simone Adamany, J. Baiker, Kerstin Allegrucci, Cinzia Polledo, L. Grau-Roma, Llorenc A thirteen-month-old male neutered orange roan English Cocker Spaniel dog was euthanized due to a prolonged history of lethargy, weight loss, severe azotemia and marked proteinuria, which was suggestive of chronic renal failure. At necropsy, both kidneys were pale tan and presented with a diffusely rough and granular appearing surface. Histologically, both kidneys showed severe, generalized, segmental to global, chronic membranoproliferative glomerulonephritis with glomerulosclerosis and proteinuria. DNA was extracted from hair follicles collected at necropsy, and a PCR amplifying exon 3 of gene COL4A4 was performed. The PCR showed that this dog had a homozygous mutation at the position 115 of the gene COL4A4, indicating that this dog suffered from hereditary nephropathy. American Veterinary Medical Association 2015-09-01 Article PeerReviewed de Brot, Simone, Adamany, J., Baiker, Kerstin, Allegrucci, Cinzia, Polledo, L. and Grau-Roma, Llorenc (2015) Hereditary nephropathy in an English Cocker Spaniel. Journal of the American Veterinary Medical Association . ISSN 1943-569X (In Press) |
| spellingShingle | de Brot, Simone Adamany, J. Baiker, Kerstin Allegrucci, Cinzia Polledo, L. Grau-Roma, Llorenc Hereditary nephropathy in an English Cocker Spaniel |
| title | Hereditary nephropathy in an English Cocker Spaniel |
| title_full | Hereditary nephropathy in an English Cocker Spaniel |
| title_fullStr | Hereditary nephropathy in an English Cocker Spaniel |
| title_full_unstemmed | Hereditary nephropathy in an English Cocker Spaniel |
| title_short | Hereditary nephropathy in an English Cocker Spaniel |
| title_sort | hereditary nephropathy in an english cocker spaniel |
| url | https://eprints.nottingham.ac.uk/37944/ |