Suppression of PKC-α attenuates TNF-α-evoked cerebral barrier breakdown via regulations of MMP-2 and plasminogen–plasmin system

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Suppression of PKC-α attenuates TNF-α-evoked cerebral barrier breakdown via regulations of MMP-2 and plasminogen–plasmin system

Ischaemic stroke, accompanied by neuroinflammation, impairs blood-brain barrier integrity through a complex mechanism involving both protein kinase C (PKC) and urokinase. Using an in vitro model of human blood-brain barrier (BBB) composed of brain microvascular endothelial cells (HBMEC) and astrocyt...

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Bibliographic Details
Main Authors:	Abdullah, Zuraidah, Bayraktutan, Ulvi
Format:	Article
Published:	Elsevier 2016
Subjects:	TNF-α; blood-brain barrier; PKC-α; PPS components; MMP-2; claudin-5; apoptosis; stress fibres
Online Access:	https://eprints.nottingham.ac.uk/37937/

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