Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection
Tuberculosis (TB) causes significant morbidity and mortality on a global scale. The African region has 24% of the world's TB cases. TB overlaps with other infectious diseases such as malaria and HIV, which are also highly prevalent in the African region. TB is a leading cause of death among HIV...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
Wiley
2016
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/37827/ |
| _version_ | 1848795543601414144 |
|---|---|
| author | Chukwuanukwu, Rebecca C. Onyenekwe, Charles C. Martinez-Pomares, Luisa Flynn, Robin J. Singh, Sonali Amilo, Grace I. Agbakoba, Nneka R. Okoye, Jude O. |
| author_facet | Chukwuanukwu, Rebecca C. Onyenekwe, Charles C. Martinez-Pomares, Luisa Flynn, Robin J. Singh, Sonali Amilo, Grace I. Agbakoba, Nneka R. Okoye, Jude O. |
| author_sort | Chukwuanukwu, Rebecca C. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Tuberculosis (TB) causes significant morbidity and mortality on a global scale. The African region has 24% of the world's TB cases. TB overlaps with other infectious diseases such as malaria and HIV, which are also highly prevalent in the African region. TB is a leading cause of death among HIV-positive patients and co-infection with HIV and TB has been described as a syndemic. In view of the overlapping epidemiology of these diseases, it is important to understand the dynamics of the immune response to TB in the context of co-infection. We investigated the cytokine response to purified protein derivative (PPD) in peripheral blood mononuclear cells from TB patients co-infected with HIV or malaria and compared it to that of malaria- and HIV-free TB patients. A total of 231 subjects were recruited for this study and classified into six groups; untreated TB-positive, TB positive subjects on TB drugs, TB- and HIV-positive, TB- and malaria-positive, latent TB and apparently healthy control subjects. Our results demonstrate maintenance of interferon (IFN)-γ production in HIV and malaria co-infected TB patients in spite of lower CD4 counts in the HIV-infected cohort. Malaria co-infection caused an increase in the production of the T helper type 2 (Th2)-associated cytokine interleukin (IL)-4 and the anti-inflammatory cytokine IL-10 in PPD-stimulated cultures. These results suggest that malaria co-infection diverts immune response against M. tuberculosis towards a Th-2/anti-inflammatory response which might have important consequences for disease progression. |
| first_indexed | 2025-11-14T19:33:46Z |
| format | Article |
| id | nottingham-37827 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:33:46Z |
| publishDate | 2016 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-378272020-05-04T18:16:04Z https://eprints.nottingham.ac.uk/37827/ Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection Chukwuanukwu, Rebecca C. Onyenekwe, Charles C. Martinez-Pomares, Luisa Flynn, Robin J. Singh, Sonali Amilo, Grace I. Agbakoba, Nneka R. Okoye, Jude O. Tuberculosis (TB) causes significant morbidity and mortality on a global scale. The African region has 24% of the world's TB cases. TB overlaps with other infectious diseases such as malaria and HIV, which are also highly prevalent in the African region. TB is a leading cause of death among HIV-positive patients and co-infection with HIV and TB has been described as a syndemic. In view of the overlapping epidemiology of these diseases, it is important to understand the dynamics of the immune response to TB in the context of co-infection. We investigated the cytokine response to purified protein derivative (PPD) in peripheral blood mononuclear cells from TB patients co-infected with HIV or malaria and compared it to that of malaria- and HIV-free TB patients. A total of 231 subjects were recruited for this study and classified into six groups; untreated TB-positive, TB positive subjects on TB drugs, TB- and HIV-positive, TB- and malaria-positive, latent TB and apparently healthy control subjects. Our results demonstrate maintenance of interferon (IFN)-γ production in HIV and malaria co-infected TB patients in spite of lower CD4 counts in the HIV-infected cohort. Malaria co-infection caused an increase in the production of the T helper type 2 (Th2)-associated cytokine interleukin (IL)-4 and the anti-inflammatory cytokine IL-10 in PPD-stimulated cultures. These results suggest that malaria co-infection diverts immune response against M. tuberculosis towards a Th-2/anti-inflammatory response which might have important consequences for disease progression. Wiley 2016-10-21 Article PeerReviewed Chukwuanukwu, Rebecca C., Onyenekwe, Charles C., Martinez-Pomares, Luisa, Flynn, Robin J., Singh, Sonali, Amilo, Grace I., Agbakoba, Nneka R. and Okoye, Jude O. (2016) Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection. Clinical and Experimental Immunology, 187 (2). pp. 259-268. ISSN 1365-2249 co-infection cytokines HIV malaria tuberculosis http://onlinelibrary.wiley.com/doi/10.1111/cei.12861/abstract doi:10.1111/cei.12861 doi:10.1111/cei.12861 |
| spellingShingle | co-infection cytokines HIV malaria tuberculosis Chukwuanukwu, Rebecca C. Onyenekwe, Charles C. Martinez-Pomares, Luisa Flynn, Robin J. Singh, Sonali Amilo, Grace I. Agbakoba, Nneka R. Okoye, Jude O. Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection |
| title | Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection |
| title_full | Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection |
| title_fullStr | Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection |
| title_full_unstemmed | Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection |
| title_short | Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection |
| title_sort | modulation of the immune response to mycobacterium tuberculosis during malaria/m. tuberculosis co-infection |
| topic | co-infection cytokines HIV malaria tuberculosis |
| url | https://eprints.nottingham.ac.uk/37827/ https://eprints.nottingham.ac.uk/37827/ https://eprints.nottingham.ac.uk/37827/ |