The effect of paratuberculosis on milk yield—a systematic review and meta-analysis
Bovine paratuberculosis is a disease characterized by chronic granulomatous enteritis causing protein-losing enteropathy. Adverse effects on animal productivity are key drivers in the attempt to control paratuberculosis at the farm level. Economic models require an accurate estimation of the product...
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| Format: | Article |
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American Dairy Science Association
2016
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| Online Access: | https://eprints.nottingham.ac.uk/37799/ |
| _version_ | 1848795536903110656 |
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| author | McAloon, Conor G. Whyte, Paul More, Simon J. Green, Martin J. O’Grady, Luke Garcia, AnaBelen Doherty, Michael L. |
| author_facet | McAloon, Conor G. Whyte, Paul More, Simon J. Green, Martin J. O’Grady, Luke Garcia, AnaBelen Doherty, Michael L. |
| author_sort | McAloon, Conor G. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Bovine paratuberculosis is a disease characterized by chronic granulomatous enteritis causing protein-losing enteropathy. Adverse effects on animal productivity are key drivers in the attempt to control paratuberculosis at the farm level. Economic models require an accurate estimation of the production effects associated with paratuberculosis. The aim of this study was to conduct a systematic review and meta-analysis to investigate the effect of paratuberculosis on milk production. A total of 20 effect estimates from 15 studies were included in the final meta-analysis. Substantial between-study heterogeneity was observed. Subgroup analysis by case definition and study design was carried out to investigate heterogeneity. The majority of between-study variation was attributed to studies that defined cases on serology. Calculation of a pooled effect estimate was only appropriate for studies that defined cases by organism detection. A reduction in milk yield, corrected for lactation number and herd of origin of 1.87 kg/d, equivalent to 5.9% of yield, was associated with fecal culture or PCR positivity in individual cows. |
| first_indexed | 2025-11-14T19:33:39Z |
| format | Article |
| id | nottingham-37799 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:33:39Z |
| publishDate | 2016 |
| publisher | American Dairy Science Association |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-377992020-05-04T20:04:13Z https://eprints.nottingham.ac.uk/37799/ The effect of paratuberculosis on milk yield—a systematic review and meta-analysis McAloon, Conor G. Whyte, Paul More, Simon J. Green, Martin J. O’Grady, Luke Garcia, AnaBelen Doherty, Michael L. Bovine paratuberculosis is a disease characterized by chronic granulomatous enteritis causing protein-losing enteropathy. Adverse effects on animal productivity are key drivers in the attempt to control paratuberculosis at the farm level. Economic models require an accurate estimation of the production effects associated with paratuberculosis. The aim of this study was to conduct a systematic review and meta-analysis to investigate the effect of paratuberculosis on milk production. A total of 20 effect estimates from 15 studies were included in the final meta-analysis. Substantial between-study heterogeneity was observed. Subgroup analysis by case definition and study design was carried out to investigate heterogeneity. The majority of between-study variation was attributed to studies that defined cases on serology. Calculation of a pooled effect estimate was only appropriate for studies that defined cases by organism detection. A reduction in milk yield, corrected for lactation number and herd of origin of 1.87 kg/d, equivalent to 5.9% of yield, was associated with fecal culture or PCR positivity in individual cows. American Dairy Science Association 2016-02 Article PeerReviewed McAloon, Conor G., Whyte, Paul, More, Simon J., Green, Martin J., O’Grady, Luke, Garcia, AnaBelen and Doherty, Michael L. (2016) The effect of paratuberculosis on milk yield—a systematic review and meta-analysis. Journal of Dairy Science, 99 (2). pp. 1449-1460. ISSN 1525-3198 paratuberculosis; Johne’s disease; meta-analysis; milk yield http://www.sciencedirect.com/science/article/pii/S0022030215008978 doi:10.3168/jds.2015-10156 doi:10.3168/jds.2015-10156 |
| spellingShingle | paratuberculosis; Johne’s disease; meta-analysis; milk yield McAloon, Conor G. Whyte, Paul More, Simon J. Green, Martin J. O’Grady, Luke Garcia, AnaBelen Doherty, Michael L. The effect of paratuberculosis on milk yield—a systematic review and meta-analysis |
| title | The effect of paratuberculosis on milk yield—a systematic review and meta-analysis |
| title_full | The effect of paratuberculosis on milk yield—a systematic review and meta-analysis |
| title_fullStr | The effect of paratuberculosis on milk yield—a systematic review and meta-analysis |
| title_full_unstemmed | The effect of paratuberculosis on milk yield—a systematic review and meta-analysis |
| title_short | The effect of paratuberculosis on milk yield—a systematic review and meta-analysis |
| title_sort | effect of paratuberculosis on milk yield—a systematic review and meta-analysis |
| topic | paratuberculosis; Johne’s disease; meta-analysis; milk yield |
| url | https://eprints.nottingham.ac.uk/37799/ https://eprints.nottingham.ac.uk/37799/ https://eprints.nottingham.ac.uk/37799/ |