Evaluation of the PPAR-γ agonist pioglitazone in mild asthma: a double-blind randomized controlled trial

QR Code

Evaluation of the PPAR-γ agonist pioglitazone in mild asthma: a double-blind randomized controlled trial

Background Peroxisome proliferator-activated receptor gamma (PPAR-γ) is a nuclear receptor that modulates inflammation in models of asthma. To determine whether pioglitazone improves measures of asthma control and airway inflammation, we performed a single-center randomized, double-blind, placebo...

Full description

Bibliographic Details
Main Authors:	Leroyer, Christophe, Anderson, J.R., Mortimer, K., Pang, L., Smith, K.M., Bailey, H., Hodgson, D.B., Shaw, Dominick E., Knox, A.J., Harrison, Timothy W.
Format:	Article
Published:	Public Library of Science 2016
Online Access:	https://eprints.nottingham.ac.uk/37796/

Similar Items

Evaluation of the PPAR-γ agonist pioglitazone in mild asthma: a double-blind randomized controlled trial
by: Anderson, J.R., et al.
Published: (2016)

Virtual screening of pyrazole derivatives of usnic acid as new class of anti-hyperglycemic agents against PPARγ agonists
by: Roney, Miah, et al.
Published: (2023)

In silico identification of PPARγ agonists from diffractaic acid analogs in prostate cancer: a comprehensive computational approach
by: Roney, Miah, et al.
Published: (2025)

Predictors of severe exacerbations, poor asthma control, and β-agonist overuse for patients with asthma
by: Patel, Mitesh, et al.
Published: (2014)

The Effects Of Pioglitazone And MK886 ON THE Mrna EXPRESSION OF PPAR-alpha, PPAR-gamma And Its Associated GENES, Cell Death And Migration In MDA-MB- 231 Cancer Cells
by: Nadarajan, Kalpanah
Published: (2015)

PPARγ disease gene network and identification of therapeutic targets for prostate cancer
by: Venkatachalam, G., et al.
Published: (2011)

Short-acting β-agonist use as a marker of current asthma control
by: Patel, Mitesh, et al.
Published: (2013)

Anticancer activity of thymoquinone in breast cancer cells: Possible involvement of PPAR-γ pathway
by: Woo, C., et al.
Published: (2011)

Elucidating hepatic lipidosis in stray cats through serum biochemistry, liver histopathology and liver RNA expression of PPAR-δ and PPAR-γ
by: F. Salleh,, et al.
Published: (2022)

The effects of azithromycin in treatment-resistant cough: a randomized, double-blind, placebo-controlled trial
by: Hodgson, David, et al.
Published: (2016)

Design and Evaluation of a Human Microglia Model: Drug Delivery and the Inhibitory Impact of PPARβ Agonist on Inflammation
by: Aloufi, Rawan
Published: (2024)

Identification of novel peroxisome proliferator-activated receptor-gamma (PPAR[gamma]) agonists using molecular modeling method
by: Kumar, Alan Prem
Published: (2014)

Role Of Peroxisome Proliferator Activated Receptor-γ ( PPARγ) Ligands On The Foam Cell Formation Derived From MNV-1 Infected Macrophages
by: Musa, Khirun
Published: (2017)

Omega 3 polyunsaturated fatty acid improves spatial learning and hippocampal Peroxisome Proliferator Activated Receptors (PPARα and PPARγ) gene expression in rats
by: Hajjar, Toktam, et al.
Published: (2012)

Xanthones from Garcinia Malaccencis improve Glut4 aswell as decreased Pparγ activation on adipocytes
by: Bakhtiar, M. Taher, et al.
Published: (2013)

Haemodynamic Effects Of Adiponectin On PPAR–γ Receptors In Diabetic And Nondiabetic Wistar Kyoto And Spontaneously Hypertensive Rats
by: Afzal, Sheryar
Published: (2017)

Ciglitazone inhibits growth and induces apoptosis in human colorectal cancer cell lines independently of PPARγ
by: Darus, Halisa Mohd, et al.
Published: (2004)

The use of β2-agonist therapy before hospital attendance for severe asthma exacerbations: a post-hoc analysis
by: Patel, Mitesh, et al.
Published: (2015)

ß2-adrenoceptor polymorphisms predict response to ß2-agonists in children with acute asthma
by: Martin, A., et al.
Published: (2008)

Antiobesity effects of α-mangostin through glut4 and leptin expression together with pparγ activation in adipocytes
by: Bakhtiar, M. Taher, et al.
Published: (2013)

Molecular characterization of peroxisome proliferator activated receptor gamma2 (PPARγ2) promoter from bovine
by: Ismail, Ida Shazrina, et al.
Published: (2004)

Molecular characterization of peroxisome proliferator activated receptor gamma2 (PPARγ2) promoter from bovine
by: Ismail, Ida Shazrina, et al.
Published: (2004)

Pioglitazone is anti-inflammatory in human liver and reduces stellate cell activation and proliferation
by: Abdul Rahim, Roslina, et al.
Published: (2011)

Perfluorooctane sulfonate induces neuronal and oligodendrocytic differentiation in neural stem cells and alters the expression of PPARγ in vitro and in vivo
by: Wan Ibrahim, Wan Norhamidah, et al.
Published: (2013)

The Underlying molecular mechanism of bufei yishen prescription for copd in mice model based on NFR1/PPAR γ pathway
by: Xu, Cong
Published: (2024)

A randomised controlled trial of small particle inhaled steroids in refractory eosinophilic asthma (SPIRA)
by: Hodgson, David, et al.
Published: (2015)

Homology Modeling and Molecular Docking Studies on Type II Diabetes Complications Reduced PPARγ Receptor with Various Ligand Molecules
by: Prabhu, S., et al.
Published: (2017)

Beta-agonist overuse and delay in obtaining medical review in high risk asthma: a secondary analysis of data from a randomised controlled trial
by: Pilcher, Janine, et al.
Published: (2017)

Inhibition of adult liver progenitor (oval) cell growth and viability by an agonist of the peroxisome proliferator activated receptor (PPAR) family member gamma, but not alpha or delta
by: Knight, B., et al.
Published: (2005)

Assessment of preclinical pharmacokinetics and acute toxicity of pioglitazone and telmisartan combination
by: Sengupta, Pinaki Ranjan, et al.
Published: (2017)

Synergism between cAMP and PPARγ signalling in the initiation of UCP1 gene expression in HIB1B brown adipocytes
by: Chen, H.Y., et al.
Published: (2013)

Inhaled corticosteroids and the risk of pneumonia in people with asthma
by: McKeever, Tricia M., et al.
Published: (2013)

Beneficial alteration of blood biochemical parameters by Telmisartan-Pioglitazone combination in rat
by: Ibrahim, Fuzianna, et al.
Published: (2016)

The Effect Of Peroxisome Proliferatorr Activated Receptor Gamma (Pparγ) On The Expression Of Foxp3, Tigit, Icos And Histone Proteins In Natural T-Regulatory Cells
by: Lee, Pei Chen
Published: (2019)

Association Of Peroxisome Proliferator-Activated Receptors (Ppars) Α, Γ And Δ Gene Polymorphisms With Obesity And Metabolic Syndrome In The Sub-Urban Kampar Population, Malaysia
by: Phee, Chia Phee
Published: (2015)

Safety profiling of pioglitazone and telmisartan combination by sub-chronic toxicity study in rat
by: Sengupta, Pinaki, et al.
Published: (2016)

Molecular mechanisms underlying the effect of pioglitazone therapy in Non-Alcoholic Steatohepatitis (NASH)
by: Abdul Rahim, Roslina, et al.
Published: (2009)

The expression of PPARS gamma in the cervical cancer line, hela and the effects of specific PPAR ligand on cell growth
by: Yaacob, Nik Soriani
Published: (2013)

The expression of ppars gamma in the cervical cancer line, bela and the effects of specific PPAR ligand on cell growth
by: Yaacob, Nik Soriani
Published: (2013)

Exhaled nitric oxide and inhaled corticosteroid dose reduction in asthma: a cohort study
by: Wilson, Emma, et al.
Published: (2014)