Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis

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Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis

Objectives: Tropomyosin receptor kinase A (TrkA) mediates nociceptor sensitisation by nerve growth factor (NGF), but it is unknown whether selective TrkA inhibition will be an effective strategy for treating osteoarthritis (OA) pain. We determined the effects of a TrkA inhibitor (AR786) on pain beha...

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Bibliographic Details
Main Authors:	Nwosu, Lilian Ngozi, Mapp, Paul I., Chapman, Victoria, Walsh, David A.
Format:	Article
Published:	BMJ Publishing Group 2015
Online Access:	https://eprints.nottingham.ac.uk/37790/

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