Effect of early and current Helicobacter pylori infection on the risk of anaemia in 6.5-year-old Ethiopian children
Background Epidemiological and clinical studies in high income countries have suggested that Helicobacter pylori (H. pylori) may cause anaemia, but evidence is lacking from low income countries.We examined associations between H. pylori infection in early childhood and anaemia at the age of 6.5 y...
| Main Authors: | , , , , , , , |
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| Format: | Article |
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BioMed Central
2015
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| Online Access: | https://eprints.nottingham.ac.uk/37776/ |
| _version_ | 1848795531580538880 |
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| author | Taye, Bineyam Enquselassie, Fikre Tsegaye, Aster Amberbir, Alemayehu Medhin, Girmay Fogarty, Andrew W. Robinson, Karen Davey, Gail |
| author_facet | Taye, Bineyam Enquselassie, Fikre Tsegaye, Aster Amberbir, Alemayehu Medhin, Girmay Fogarty, Andrew W. Robinson, Karen Davey, Gail |
| author_sort | Taye, Bineyam |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background
Epidemiological and clinical studies in high income countries have suggested that Helicobacter pylori (H. pylori) may cause anaemia, but evidence is lacking from low income countries.We examined associations between H. pylori infection in early childhood and anaemia at the age of 6.5 years in an Ethiopian birth cohort.
Methods
In 2011/12, 856 children (85.1 % of the 1006 original singletons in a population-based birth cohort) were followed up at age six and half. An interviewer-led questionnaire administered to mothers provided information on demographic and lifestyle variables. Haemoglobin level and red cell indices were examined using an automated haematological analyzer (Cell Dyn 1800, Abbott, USA), and stool samples analyzed for H. pylori antigen. The independent effects of H. pylori infection (measured at age 3.5 and 6.5 years) on anaemia, haemoglobin level, and red cell indices (measured at age 6.5 years) were determined using multiple logistic and linear regression.
Results
The prevalence of anemia was 34.8 % (257/739), and the mean (SD) haemoglobin concentration was 11.8 (1.1) gm/dl. Current H. pylori infection at age 6.5 years was positively, though not significantly related to prevalence of anaemia (adjusted OR, 95 % CI, 1.15; 0.69, 1.93, p = 0.59). Any H. pylori infection up to age 6.5 years was significantly associated with an increased risk of anaemia at age 6.5 (adjusted OR, 95 % CI, 1.68; 1.22, 2.32, p = 0.01). A significant reduction in haemoglobin concentration and red cell indices was also observed among children who had any H. pylori infection up to age 6.5 (Hb adjusted β = −0.19, 95 % CI, −0.35 to −0.03, p = 0.01; MCV adjusted β = −2.22, 95 % CI, −3.43 to −1.01, p = 0.01; MCH adjusted β = −0.63, 95 % CI, −1.15 to - 0.12, p = 0.01; and MCHC adjusted β = −0.67, 95 % CI, −1.21 to −0.14, p = 0.01), respectively.
Conclusion
This study provides further evidence from a low income country that any H. pylori infection up to age 6.5 is associated with higher prevalence of anaemia, and reduction of haemoglobin level and red cell indices at age 6.5. |
| first_indexed | 2025-11-14T19:33:34Z |
| format | Article |
| id | nottingham-37776 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:33:34Z |
| publishDate | 2015 |
| publisher | BioMed Central |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-377762020-05-04T17:13:15Z https://eprints.nottingham.ac.uk/37776/ Effect of early and current Helicobacter pylori infection on the risk of anaemia in 6.5-year-old Ethiopian children Taye, Bineyam Enquselassie, Fikre Tsegaye, Aster Amberbir, Alemayehu Medhin, Girmay Fogarty, Andrew W. Robinson, Karen Davey, Gail Background Epidemiological and clinical studies in high income countries have suggested that Helicobacter pylori (H. pylori) may cause anaemia, but evidence is lacking from low income countries.We examined associations between H. pylori infection in early childhood and anaemia at the age of 6.5 years in an Ethiopian birth cohort. Methods In 2011/12, 856 children (85.1 % of the 1006 original singletons in a population-based birth cohort) were followed up at age six and half. An interviewer-led questionnaire administered to mothers provided information on demographic and lifestyle variables. Haemoglobin level and red cell indices were examined using an automated haematological analyzer (Cell Dyn 1800, Abbott, USA), and stool samples analyzed for H. pylori antigen. The independent effects of H. pylori infection (measured at age 3.5 and 6.5 years) on anaemia, haemoglobin level, and red cell indices (measured at age 6.5 years) were determined using multiple logistic and linear regression. Results The prevalence of anemia was 34.8 % (257/739), and the mean (SD) haemoglobin concentration was 11.8 (1.1) gm/dl. Current H. pylori infection at age 6.5 years was positively, though not significantly related to prevalence of anaemia (adjusted OR, 95 % CI, 1.15; 0.69, 1.93, p = 0.59). Any H. pylori infection up to age 6.5 years was significantly associated with an increased risk of anaemia at age 6.5 (adjusted OR, 95 % CI, 1.68; 1.22, 2.32, p = 0.01). A significant reduction in haemoglobin concentration and red cell indices was also observed among children who had any H. pylori infection up to age 6.5 (Hb adjusted β = −0.19, 95 % CI, −0.35 to −0.03, p = 0.01; MCV adjusted β = −2.22, 95 % CI, −3.43 to −1.01, p = 0.01; MCH adjusted β = −0.63, 95 % CI, −1.15 to - 0.12, p = 0.01; and MCHC adjusted β = −0.67, 95 % CI, −1.21 to −0.14, p = 0.01), respectively. Conclusion This study provides further evidence from a low income country that any H. pylori infection up to age 6.5 is associated with higher prevalence of anaemia, and reduction of haemoglobin level and red cell indices at age 6.5. BioMed Central 2015-07-14 Article PeerReviewed Taye, Bineyam, Enquselassie, Fikre, Tsegaye, Aster, Amberbir, Alemayehu, Medhin, Girmay, Fogarty, Andrew W., Robinson, Karen and Davey, Gail (2015) Effect of early and current Helicobacter pylori infection on the risk of anaemia in 6.5-year-old Ethiopian children. BMC Infectious Diseases, 15 (1). 270/1-270/12. ISSN 1471-2334 Helicobacter pylori Anaemia Red cell indices Birth cohort Ethiopia http://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-015-1012-y doi:10.1186/s12879-015-1012-y doi:10.1186/s12879-015-1012-y |
| spellingShingle | Helicobacter pylori Anaemia Red cell indices Birth cohort Ethiopia Taye, Bineyam Enquselassie, Fikre Tsegaye, Aster Amberbir, Alemayehu Medhin, Girmay Fogarty, Andrew W. Robinson, Karen Davey, Gail Effect of early and current Helicobacter pylori infection on the risk of anaemia in 6.5-year-old Ethiopian children |
| title | Effect of early and current Helicobacter pylori infection on the risk of anaemia in 6.5-year-old Ethiopian children |
| title_full | Effect of early and current Helicobacter pylori infection on the risk of anaemia in 6.5-year-old Ethiopian children |
| title_fullStr | Effect of early and current Helicobacter pylori infection on the risk of anaemia in 6.5-year-old Ethiopian children |
| title_full_unstemmed | Effect of early and current Helicobacter pylori infection on the risk of anaemia in 6.5-year-old Ethiopian children |
| title_short | Effect of early and current Helicobacter pylori infection on the risk of anaemia in 6.5-year-old Ethiopian children |
| title_sort | effect of early and current helicobacter pylori infection on the risk of anaemia in 6.5-year-old ethiopian children |
| topic | Helicobacter pylori Anaemia Red cell indices Birth cohort Ethiopia |
| url | https://eprints.nottingham.ac.uk/37776/ https://eprints.nottingham.ac.uk/37776/ https://eprints.nottingham.ac.uk/37776/ |