MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C
Cirrhosis likely shares common pathophysiological pathways despite arising from a variety of liver diseases. A recent GWAS identified rs641738, a polymorphism in the MBOAT7 locus, as being associated with the development of alcoholic cirrhosis. Here we explore the role of this variant on liver infla...
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| Format: | Article |
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Nature Publishing Group
2016
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| Online Access: | https://eprints.nottingham.ac.uk/37769/ |
| _version_ | 1848795529680519168 |
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| author | Thabet, Khaled Asimakopoulos, Anastasia Shojaei, Maryam Romero-Gomez, Manuel Mangia, Alessandra Irving, William L. Berg, Thomas Dore, Gregory J. Grønbæk, Henning Sheridan, David Abate, Maria Lorena Bugianesi, Elisabetta Weltman, Martin Mollison, Lindsay Cheng, Wendy Riordan, Stephen Fischer, Janett Spengler, Ulrich Nattermann, Jacob Wahid, Ahmed Rojas, Angela White, Rose Douglas, Mark W. McLeod, Duncan Powell, Elizabeth Liddle, Christopher van der Poorten, David George, Jacob Eslam, Mohammed Gallego-Duran, Rocio Applegate, Tanya Bassendine, Margaret Rosso, Chiara Mezzabotta, Lavinia Leung, Reynold Malik, Barbara Matthews, Gail Grebely, Jason Fragomeli, Vincenzo Jonsson, Julie R. Santaro, Rosanna |
| author_facet | Thabet, Khaled Asimakopoulos, Anastasia Shojaei, Maryam Romero-Gomez, Manuel Mangia, Alessandra Irving, William L. Berg, Thomas Dore, Gregory J. Grønbæk, Henning Sheridan, David Abate, Maria Lorena Bugianesi, Elisabetta Weltman, Martin Mollison, Lindsay Cheng, Wendy Riordan, Stephen Fischer, Janett Spengler, Ulrich Nattermann, Jacob Wahid, Ahmed Rojas, Angela White, Rose Douglas, Mark W. McLeod, Duncan Powell, Elizabeth Liddle, Christopher van der Poorten, David George, Jacob Eslam, Mohammed Gallego-Duran, Rocio Applegate, Tanya Bassendine, Margaret Rosso, Chiara Mezzabotta, Lavinia Leung, Reynold Malik, Barbara Matthews, Gail Grebely, Jason Fragomeli, Vincenzo Jonsson, Julie R. Santaro, Rosanna |
| author_sort | Thabet, Khaled |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Cirrhosis likely shares common pathophysiological pathways despite arising from a variety of liver diseases. A recent GWAS identified rs641738, a polymorphism in the MBOAT7 locus, as being associated with the development of alcoholic cirrhosis. Here we explore the role of this variant on liver inflammation and fibrosis in two cohorts of patients with chronic hepatitis C. In 2,051 patients, rs641738 associated with severe hepatic inflammation and increased risk of fibrosis, as well as fast fibrosis progression. At functional level, rs641738 associated with MBOAT7 transcript and protein levels in liver and blood, and with serum inflammatory, oxidative stress and macrophage activation markers. MBOAT7 was expressed in immune cell subsets, implying a role in hepatic inflammation. We conclude that the MBOAT7 rs641738 polymorphism is a novel risk variant for liver inflammation in hepatitis C, and thereby for liver fibrosis. |
| first_indexed | 2025-11-14T19:33:32Z |
| format | Article |
| id | nottingham-37769 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:33:32Z |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-377692020-05-04T18:12:20Z https://eprints.nottingham.ac.uk/37769/ MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C Thabet, Khaled Asimakopoulos, Anastasia Shojaei, Maryam Romero-Gomez, Manuel Mangia, Alessandra Irving, William L. Berg, Thomas Dore, Gregory J. Grønbæk, Henning Sheridan, David Abate, Maria Lorena Bugianesi, Elisabetta Weltman, Martin Mollison, Lindsay Cheng, Wendy Riordan, Stephen Fischer, Janett Spengler, Ulrich Nattermann, Jacob Wahid, Ahmed Rojas, Angela White, Rose Douglas, Mark W. McLeod, Duncan Powell, Elizabeth Liddle, Christopher van der Poorten, David George, Jacob Eslam, Mohammed Gallego-Duran, Rocio Applegate, Tanya Bassendine, Margaret Rosso, Chiara Mezzabotta, Lavinia Leung, Reynold Malik, Barbara Matthews, Gail Grebely, Jason Fragomeli, Vincenzo Jonsson, Julie R. Santaro, Rosanna Cirrhosis likely shares common pathophysiological pathways despite arising from a variety of liver diseases. A recent GWAS identified rs641738, a polymorphism in the MBOAT7 locus, as being associated with the development of alcoholic cirrhosis. Here we explore the role of this variant on liver inflammation and fibrosis in two cohorts of patients with chronic hepatitis C. In 2,051 patients, rs641738 associated with severe hepatic inflammation and increased risk of fibrosis, as well as fast fibrosis progression. At functional level, rs641738 associated with MBOAT7 transcript and protein levels in liver and blood, and with serum inflammatory, oxidative stress and macrophage activation markers. MBOAT7 was expressed in immune cell subsets, implying a role in hepatic inflammation. We conclude that the MBOAT7 rs641738 polymorphism is a novel risk variant for liver inflammation in hepatitis C, and thereby for liver fibrosis. Nature Publishing Group 2016-09-15 Article PeerReviewed Thabet, Khaled, Asimakopoulos, Anastasia, Shojaei, Maryam, Romero-Gomez, Manuel, Mangia, Alessandra, Irving, William L., Berg, Thomas, Dore, Gregory J., Grønbæk, Henning, Sheridan, David, Abate, Maria Lorena, Bugianesi, Elisabetta, Weltman, Martin, Mollison, Lindsay, Cheng, Wendy, Riordan, Stephen, Fischer, Janett, Spengler, Ulrich, Nattermann, Jacob, Wahid, Ahmed, Rojas, Angela, White, Rose, Douglas, Mark W., McLeod, Duncan, Powell, Elizabeth, Liddle, Christopher, van der Poorten, David, George, Jacob, Eslam, Mohammed, Gallego-Duran, Rocio, Applegate, Tanya, Bassendine, Margaret, Rosso, Chiara, Mezzabotta, Lavinia, Leung, Reynold, Malik, Barbara, Matthews, Gail, Grebely, Jason, Fragomeli, Vincenzo, Jonsson, Julie R. and Santaro, Rosanna (2016) MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C. Nature Communications, 7 . 12757/1-12757/10. ISSN 2041-1723 Genetics research; Hepatitis C; Liver fibrosis http://www.nature.com/articles/ncomms12757 doi:10.1038/ncomms12757 doi:10.1038/ncomms12757 |
| spellingShingle | Genetics research; Hepatitis C; Liver fibrosis Thabet, Khaled Asimakopoulos, Anastasia Shojaei, Maryam Romero-Gomez, Manuel Mangia, Alessandra Irving, William L. Berg, Thomas Dore, Gregory J. Grønbæk, Henning Sheridan, David Abate, Maria Lorena Bugianesi, Elisabetta Weltman, Martin Mollison, Lindsay Cheng, Wendy Riordan, Stephen Fischer, Janett Spengler, Ulrich Nattermann, Jacob Wahid, Ahmed Rojas, Angela White, Rose Douglas, Mark W. McLeod, Duncan Powell, Elizabeth Liddle, Christopher van der Poorten, David George, Jacob Eslam, Mohammed Gallego-Duran, Rocio Applegate, Tanya Bassendine, Margaret Rosso, Chiara Mezzabotta, Lavinia Leung, Reynold Malik, Barbara Matthews, Gail Grebely, Jason Fragomeli, Vincenzo Jonsson, Julie R. Santaro, Rosanna MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C |
| title | MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C |
| title_full | MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C |
| title_fullStr | MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C |
| title_full_unstemmed | MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C |
| title_short | MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C |
| title_sort | mboat7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis c |
| topic | Genetics research; Hepatitis C; Liver fibrosis |
| url | https://eprints.nottingham.ac.uk/37769/ https://eprints.nottingham.ac.uk/37769/ https://eprints.nottingham.ac.uk/37769/ |