The DARS (Dopamine Augmented Rehabilitation in Stroke) trial: protocol for a randomised controlled trial of Co-careldopa treatment in addition to routine NHS occupational and physical therapy after stroke
Background: Stroke has a huge impact, leaving more than a third of affected people with lasting disability and rehabilitation remains a cornerstone treatment in the National Health Service (NHS). Recovery of mobility and arm function post-stroke occurs through re-learning to use the affected body pa...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
BioMed Central
2014
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/37745/ |
| _version_ | 1848795525020647424 |
|---|---|
| author | Bhakta, BB Hartley, S Holloway, I Couzens, A Ford, GA Meads, D Sackley, Catherine Mary Walker, Marion F. Ruddock, SP Farrin, AJ |
| author_facet | Bhakta, BB Hartley, S Holloway, I Couzens, A Ford, GA Meads, D Sackley, Catherine Mary Walker, Marion F. Ruddock, SP Farrin, AJ |
| author_sort | Bhakta, BB |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background: Stroke has a huge impact, leaving more than a third of affected people with lasting disability and rehabilitation remains a cornerstone treatment in the National Health Service (NHS). Recovery of mobility and arm function post-stroke occurs through re-learning to use the affected body parts and/or learning to compensate with the lesser affected side. Promising evidence suggests that the addition of Co-careldopa to physical therapy and occupational therapy may improve the recovery of arm and leg movement and lead to improved function. Methods/design: Dopamine Augmented Rehabilitation in Stroke (DARS) is a multi-centre double-blind, randomised, placebo, controlled clinical trial of Co-careldopa in addition to routine NHS occupational therapy and physical therapy as part of early stroke rehabilitation. Participants will be randomised on a 1:1 basis to either Co-careldopa or placebo. The primary objective of the trial is to determine whether the addition of six weeks of Co-careldopa treatment to rehabilitation therapy can improve the proportion of patients who can walk independently eight weeks post-randomisation.
Discussion: The DARS trial will provide evidence as to whether Co-careldopa, in addition to routine NHS occupational and physical therapy, leads to a greater recovery of motor function, a reduction in carer dependency and advance rehabilitation treatments for people with stroke.
Trial registration: ISRCTN99643613 assigned on 4 December 2009. |
| first_indexed | 2025-11-14T19:33:28Z |
| format | Article |
| id | nottingham-37745 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:33:28Z |
| publishDate | 2014 |
| publisher | BioMed Central |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-377452020-05-04T16:52:38Z https://eprints.nottingham.ac.uk/37745/ The DARS (Dopamine Augmented Rehabilitation in Stroke) trial: protocol for a randomised controlled trial of Co-careldopa treatment in addition to routine NHS occupational and physical therapy after stroke Bhakta, BB Hartley, S Holloway, I Couzens, A Ford, GA Meads, D Sackley, Catherine Mary Walker, Marion F. Ruddock, SP Farrin, AJ Background: Stroke has a huge impact, leaving more than a third of affected people with lasting disability and rehabilitation remains a cornerstone treatment in the National Health Service (NHS). Recovery of mobility and arm function post-stroke occurs through re-learning to use the affected body parts and/or learning to compensate with the lesser affected side. Promising evidence suggests that the addition of Co-careldopa to physical therapy and occupational therapy may improve the recovery of arm and leg movement and lead to improved function. Methods/design: Dopamine Augmented Rehabilitation in Stroke (DARS) is a multi-centre double-blind, randomised, placebo, controlled clinical trial of Co-careldopa in addition to routine NHS occupational therapy and physical therapy as part of early stroke rehabilitation. Participants will be randomised on a 1:1 basis to either Co-careldopa or placebo. The primary objective of the trial is to determine whether the addition of six weeks of Co-careldopa treatment to rehabilitation therapy can improve the proportion of patients who can walk independently eight weeks post-randomisation. Discussion: The DARS trial will provide evidence as to whether Co-careldopa, in addition to routine NHS occupational and physical therapy, leads to a greater recovery of motor function, a reduction in carer dependency and advance rehabilitation treatments for people with stroke. Trial registration: ISRCTN99643613 assigned on 4 December 2009. BioMed Central 2014-08-08 Article PeerReviewed Bhakta, BB, Hartley, S, Holloway, I, Couzens, A, Ford, GA, Meads, D, Sackley, Catherine Mary, Walker, Marion F., Ruddock, SP and Farrin, AJ (2014) The DARS (Dopamine Augmented Rehabilitation in Stroke) trial: protocol for a randomised controlled trial of Co-careldopa treatment in addition to routine NHS occupational and physical therapy after stroke. Trials, 15 (316). pp. 1-11. ISSN 1745-6215 Stroke study protocol randomized controlled trial occupational therapy physical therapy http://trialsjournal.biomedcentral.com/articles/10.1186/1745-6215-15-316 doi:10.1186/1745-6215-15-316 doi:10.1186/1745-6215-15-316 |
| spellingShingle | Stroke study protocol randomized controlled trial occupational therapy physical therapy Bhakta, BB Hartley, S Holloway, I Couzens, A Ford, GA Meads, D Sackley, Catherine Mary Walker, Marion F. Ruddock, SP Farrin, AJ The DARS (Dopamine Augmented Rehabilitation in Stroke) trial: protocol for a randomised controlled trial of Co-careldopa treatment in addition to routine NHS occupational and physical therapy after stroke |
| title | The DARS (Dopamine Augmented Rehabilitation in Stroke) trial: protocol for a randomised controlled trial of Co-careldopa treatment in addition to routine NHS occupational and physical therapy after stroke |
| title_full | The DARS (Dopamine Augmented Rehabilitation in Stroke) trial: protocol for a randomised controlled trial of Co-careldopa treatment in addition to routine NHS occupational and physical therapy after stroke |
| title_fullStr | The DARS (Dopamine Augmented Rehabilitation in Stroke) trial: protocol for a randomised controlled trial of Co-careldopa treatment in addition to routine NHS occupational and physical therapy after stroke |
| title_full_unstemmed | The DARS (Dopamine Augmented Rehabilitation in Stroke) trial: protocol for a randomised controlled trial of Co-careldopa treatment in addition to routine NHS occupational and physical therapy after stroke |
| title_short | The DARS (Dopamine Augmented Rehabilitation in Stroke) trial: protocol for a randomised controlled trial of Co-careldopa treatment in addition to routine NHS occupational and physical therapy after stroke |
| title_sort | dars (dopamine augmented rehabilitation in stroke) trial: protocol for a randomised controlled trial of co-careldopa treatment in addition to routine nhs occupational and physical therapy after stroke |
| topic | Stroke study protocol randomized controlled trial occupational therapy physical therapy |
| url | https://eprints.nottingham.ac.uk/37745/ https://eprints.nottingham.ac.uk/37745/ https://eprints.nottingham.ac.uk/37745/ |