Open source drug discovery with the Malaria Box Compound collection for neglected diseases and beyond
A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still largely within industry. Open source drug discovery, w...
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| Format: | Article |
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Public Library of Science
2016
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| Online Access: | https://eprints.nottingham.ac.uk/37733/ |
| _version_ | 1848795522111897600 |
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| author | Phillips, Margaret A. Van Voorhis, Wesley C. Adams, John H. Adelfio, Roberto Ahyong, Vida Akabas, Myles H. Alano, Pietro Alday, Aintzane Alemán Resto, Yesmalie Alsibaee, Aishah Alzualde, Ainhoa Andrews, Katherine T. Avery, Simon V. Avery, Vicky M. Ayong, Lawrence Baker, Mark Baker, Stephen Ben Mamoun, Choukri Bhatia, Sangeeta Bickle, Quentin Bounaadja, Lotfi Bowling, Tana Bosch, Jürgen Boucher, Lauren E. Boyom, Fabrice F. Brea, Jose Brennan, Marian Burton, Audrey Caffrey, Conor R. Camarda, Grazia Carrasquilla, Manuela Carter, Dee Belen Cassera, Maria Chih-Chien Cheng, Ken Chindaudomsate, Worathad Chubb, Anthony Colon, Beatrice L. Colón-López, Daisy D. Corbett, Yolanda Crowther, Gregory J. Cowan, Noemi D’Alessandro, Sarah Le Dang, Na Delves, Michael DeRisi, Joseph L. Du, Alan Y. Duffy, Sandra Abd El-Salam El-Sayed, Shimaa Ferdig, Michael T. Fernández Robledo, José A. Fidock, David A. Florent, Isabelle Fokou, Patrick V. T. Galstian, Ani Gamo, Francisco Javier Gokool, Suzanne Gold, Ben Golub, Todd Goldgof, Gregory M. Guha, Rajarshi Guiguemde, W. Armand Gural, Nil Guy, R. Kiplin Hansen, Michael A. E. Hanson, Kirsten K. Hemphill, Andrew Hooft van Huijsduijnen, Rob Horii, Takaaki Horrocks, Paul Hughes, Tyler B. Huston, Christopher Igarashi, Ikuo Ingram-Sieber, Katrin Itoe, Maurice A. Jadhav, Ajit Naranuntarat Jensen, Amornrat Jensen, Laran T. Jiang, Rays H.Y. Kaiser, Annette Keiser, Jennifer Ketas, Thomas Kicka, Sebastien Kim, Sunyoung Kirk, Kiaran Kumar, Vidya P. Kyle, Dennis E. Lafuente, Maria Jose Landfear, Scott Lee, Nathan Lee, Sukjun Lehane, Adele M. Li, Fengwu Little, David Liu, Liqiong Llinás, Manuel Loza, Maria I. Lubar, Aristea Lucantoni, Leonardo Lucet, Isabelle Maes, Louis Mancama, Dalu Mansour, Nuha R. March, Sandra McGowan, Sheena Medina Vera, Iset Meister, Stephan Mercer, Luke Mestres, Jordi Mfopa, Alvine N. Misra, Raj N. Moon, Seunghyun Moore, John P. Morais Rodrigues da Costa, Francielly Müller, Joachim Muriana, Arantza Nakazawa Hewitt, Stephen Nare, Bakela Nathan, Carl Narraidoo, Nathalie Nawaratna, Sujeevi Ojo, Kayode K. Ortiz, Diana Panic, Gordana Papadatos, George Parapini, Silvia Patra, Kailash Pham, Ngoc Prats, Sarah Plouffe, David M. Poulsen, Sally-Ann Pradhan, Anupam Quevedo, Celia Quinn, Ronald J. Rice, Christopher A. Abdo Rizk, Mohamed Ruecker, Andrea St. Onge, Robert Salgado Ferreira, Rafaela Samra, Jasmeet Robinett, Natalie G. Schlecht, Ulrich Schmitt, Marjorie Silva Villela, Filipe Silvestrini, Francesco Sinden, Robert Smith, Dennis A. Soldati, Thierry Spitzmüller, Andreas Stamm, Serge Maximilian Sullivan, David J. Sullivan, William Suresh, Sundari Suzuki, Brian M. Suzuki, Yo Swamidass, S. Joshua Taramelli, Donatella Tchokouaha, Lauve R.Y. Theron, Anjo Thomas, David Tonissen, Kathryn F. Townson, Simon Tripathi, Abhai K. Trofimov, Valentin Udenze, Kenneth O. Ullah, Imran Vallieres, Cindy Vigil, Edgar Vinetz, Joseph M. Voong Vinh, Phat Vu, Hoan Watanabe, Nao-aki Weatherby, Kate White, Pamela M. Wilks, Andrew F. Winzeler, Elizabeth A. Wojcik, Edward Wree, Melanie Wu, Wesley Yokoyama, Naoaki Zollo, Paul H. A. Abla, Nada Blasco, Benjamin Burrows, Jeremy Laleu, Benoît Leroy, Didier Spangenberg, Thomas Wells, Timothy Willis, Paul A. |
| author_facet | Phillips, Margaret A. Van Voorhis, Wesley C. Adams, John H. Adelfio, Roberto Ahyong, Vida Akabas, Myles H. Alano, Pietro Alday, Aintzane Alemán Resto, Yesmalie Alsibaee, Aishah Alzualde, Ainhoa Andrews, Katherine T. Avery, Simon V. Avery, Vicky M. Ayong, Lawrence Baker, Mark Baker, Stephen Ben Mamoun, Choukri Bhatia, Sangeeta Bickle, Quentin Bounaadja, Lotfi Bowling, Tana Bosch, Jürgen Boucher, Lauren E. Boyom, Fabrice F. Brea, Jose Brennan, Marian Burton, Audrey Caffrey, Conor R. Camarda, Grazia Carrasquilla, Manuela Carter, Dee Belen Cassera, Maria Chih-Chien Cheng, Ken Chindaudomsate, Worathad Chubb, Anthony Colon, Beatrice L. Colón-López, Daisy D. Corbett, Yolanda Crowther, Gregory J. Cowan, Noemi D’Alessandro, Sarah Le Dang, Na Delves, Michael DeRisi, Joseph L. Du, Alan Y. Duffy, Sandra Abd El-Salam El-Sayed, Shimaa Ferdig, Michael T. Fernández Robledo, José A. Fidock, David A. Florent, Isabelle Fokou, Patrick V. T. Galstian, Ani Gamo, Francisco Javier Gokool, Suzanne Gold, Ben Golub, Todd Goldgof, Gregory M. Guha, Rajarshi Guiguemde, W. Armand Gural, Nil Guy, R. Kiplin Hansen, Michael A. E. Hanson, Kirsten K. Hemphill, Andrew Hooft van Huijsduijnen, Rob Horii, Takaaki Horrocks, Paul Hughes, Tyler B. Huston, Christopher Igarashi, Ikuo Ingram-Sieber, Katrin Itoe, Maurice A. Jadhav, Ajit Naranuntarat Jensen, Amornrat Jensen, Laran T. Jiang, Rays H.Y. Kaiser, Annette Keiser, Jennifer Ketas, Thomas Kicka, Sebastien Kim, Sunyoung Kirk, Kiaran Kumar, Vidya P. Kyle, Dennis E. Lafuente, Maria Jose Landfear, Scott Lee, Nathan Lee, Sukjun Lehane, Adele M. Li, Fengwu Little, David Liu, Liqiong Llinás, Manuel Loza, Maria I. Lubar, Aristea Lucantoni, Leonardo Lucet, Isabelle Maes, Louis Mancama, Dalu Mansour, Nuha R. March, Sandra McGowan, Sheena Medina Vera, Iset Meister, Stephan Mercer, Luke Mestres, Jordi Mfopa, Alvine N. Misra, Raj N. Moon, Seunghyun Moore, John P. Morais Rodrigues da Costa, Francielly Müller, Joachim Muriana, Arantza Nakazawa Hewitt, Stephen Nare, Bakela Nathan, Carl Narraidoo, Nathalie Nawaratna, Sujeevi Ojo, Kayode K. Ortiz, Diana Panic, Gordana Papadatos, George Parapini, Silvia Patra, Kailash Pham, Ngoc Prats, Sarah Plouffe, David M. Poulsen, Sally-Ann Pradhan, Anupam Quevedo, Celia Quinn, Ronald J. Rice, Christopher A. Abdo Rizk, Mohamed Ruecker, Andrea St. Onge, Robert Salgado Ferreira, Rafaela Samra, Jasmeet Robinett, Natalie G. Schlecht, Ulrich Schmitt, Marjorie Silva Villela, Filipe Silvestrini, Francesco Sinden, Robert Smith, Dennis A. Soldati, Thierry Spitzmüller, Andreas Stamm, Serge Maximilian Sullivan, David J. Sullivan, William Suresh, Sundari Suzuki, Brian M. Suzuki, Yo Swamidass, S. Joshua Taramelli, Donatella Tchokouaha, Lauve R.Y. Theron, Anjo Thomas, David Tonissen, Kathryn F. Townson, Simon Tripathi, Abhai K. Trofimov, Valentin Udenze, Kenneth O. Ullah, Imran Vallieres, Cindy Vigil, Edgar Vinetz, Joseph M. Voong Vinh, Phat Vu, Hoan Watanabe, Nao-aki Weatherby, Kate White, Pamela M. Wilks, Andrew F. Winzeler, Elizabeth A. Wojcik, Edward Wree, Melanie Wu, Wesley Yokoyama, Naoaki Zollo, Paul H. A. Abla, Nada Blasco, Benjamin Burrows, Jeremy Laleu, Benoît Leroy, Didier Spangenberg, Thomas Wells, Timothy Willis, Paul A. |
| author_sort | Phillips, Margaret A. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still largely within industry. Open source drug discovery, with sharing of information, is clearly a first step towards overcoming this gap. But the interface could especially be bridged through a scale-up of open sharing of physical compounds, which would accelerate the finding of new starting points for drug discovery. The Medicines for Malaria Venture Malaria Box is a collection of over 400 compounds representing families of structures identified in phenotypic screens of pharmaceutical and academic libraries against the Plasmodium falciparum malaria parasite. The set has now been distributed to almost 200 research groups globally in the last two years, with the only stipulation that information from the screens is deposited in the public domain. This paper reports for the first time on 236 screens that have been carried out against the Malaria Box and compares these results with 55 assays that were previously published, in a format that allows a meta-analysis of the combined dataset. The combined biochemical and cellular assays presented here suggest mechanisms of action for 135 (34%) of the compounds active in killing multiple life-cycle stages of the malaria parasite, including asexual blood, liver, gametocyte, gametes and insect ookinete stages. In addition, many compounds demonstrated activity against other pathogens, showing hits in assays with 16 protozoa, 7 helminths, 9 bacterial and mycobacterial species, the dengue fever mosquito vector, and the NCI60 human cancer cell line panel of 60 human tumor cell lines. Toxicological, pharmacokinetic and metabolic properties were collected on all the compounds, assisting in the selection of the most promising candidates for murine proof-of-concept experiments and medicinal chemistry programs. The data for all of these assays are presented and analyzed to show how outstanding leads for many indications can be selected. These results reveal the immense potential for translating the dispersed expertise in biological assays involving human pathogens into drug discovery starting points, by providing open access to new families of molecules, and emphasize how a small additional investment made to help acquire and distribute compounds, and sharing the data, can catalyze drug discovery for dozens of different indications. Another lesson is that when multiple screens from different groups are run on the same library, results can be integrated quickly to select the most valuable starting points for subsequent medicinal chemistry efforts. |
| first_indexed | 2025-11-14T19:33:25Z |
| format | Article |
| id | nottingham-37733 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:33:25Z |
| publishDate | 2016 |
| publisher | Public Library of Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-377332020-05-04T17:59:19Z https://eprints.nottingham.ac.uk/37733/ Open source drug discovery with the Malaria Box Compound collection for neglected diseases and beyond Phillips, Margaret A. Van Voorhis, Wesley C. Adams, John H. Adelfio, Roberto Ahyong, Vida Akabas, Myles H. Alano, Pietro Alday, Aintzane Alemán Resto, Yesmalie Alsibaee, Aishah Alzualde, Ainhoa Andrews, Katherine T. Avery, Simon V. Avery, Vicky M. Ayong, Lawrence Baker, Mark Baker, Stephen Ben Mamoun, Choukri Bhatia, Sangeeta Bickle, Quentin Bounaadja, Lotfi Bowling, Tana Bosch, Jürgen Boucher, Lauren E. Boyom, Fabrice F. Brea, Jose Brennan, Marian Burton, Audrey Caffrey, Conor R. Camarda, Grazia Carrasquilla, Manuela Carter, Dee Belen Cassera, Maria Chih-Chien Cheng, Ken Chindaudomsate, Worathad Chubb, Anthony Colon, Beatrice L. Colón-López, Daisy D. Corbett, Yolanda Crowther, Gregory J. Cowan, Noemi D’Alessandro, Sarah Le Dang, Na Delves, Michael DeRisi, Joseph L. Du, Alan Y. Duffy, Sandra Abd El-Salam El-Sayed, Shimaa Ferdig, Michael T. Fernández Robledo, José A. Fidock, David A. Florent, Isabelle Fokou, Patrick V. T. Galstian, Ani Gamo, Francisco Javier Gokool, Suzanne Gold, Ben Golub, Todd Goldgof, Gregory M. Guha, Rajarshi Guiguemde, W. Armand Gural, Nil Guy, R. Kiplin Hansen, Michael A. E. Hanson, Kirsten K. Hemphill, Andrew Hooft van Huijsduijnen, Rob Horii, Takaaki Horrocks, Paul Hughes, Tyler B. Huston, Christopher Igarashi, Ikuo Ingram-Sieber, Katrin Itoe, Maurice A. Jadhav, Ajit Naranuntarat Jensen, Amornrat Jensen, Laran T. Jiang, Rays H.Y. Kaiser, Annette Keiser, Jennifer Ketas, Thomas Kicka, Sebastien Kim, Sunyoung Kirk, Kiaran Kumar, Vidya P. Kyle, Dennis E. Lafuente, Maria Jose Landfear, Scott Lee, Nathan Lee, Sukjun Lehane, Adele M. Li, Fengwu Little, David Liu, Liqiong Llinás, Manuel Loza, Maria I. Lubar, Aristea Lucantoni, Leonardo Lucet, Isabelle Maes, Louis Mancama, Dalu Mansour, Nuha R. March, Sandra McGowan, Sheena Medina Vera, Iset Meister, Stephan Mercer, Luke Mestres, Jordi Mfopa, Alvine N. Misra, Raj N. Moon, Seunghyun Moore, John P. Morais Rodrigues da Costa, Francielly Müller, Joachim Muriana, Arantza Nakazawa Hewitt, Stephen Nare, Bakela Nathan, Carl Narraidoo, Nathalie Nawaratna, Sujeevi Ojo, Kayode K. Ortiz, Diana Panic, Gordana Papadatos, George Parapini, Silvia Patra, Kailash Pham, Ngoc Prats, Sarah Plouffe, David M. Poulsen, Sally-Ann Pradhan, Anupam Quevedo, Celia Quinn, Ronald J. Rice, Christopher A. Abdo Rizk, Mohamed Ruecker, Andrea St. Onge, Robert Salgado Ferreira, Rafaela Samra, Jasmeet Robinett, Natalie G. Schlecht, Ulrich Schmitt, Marjorie Silva Villela, Filipe Silvestrini, Francesco Sinden, Robert Smith, Dennis A. Soldati, Thierry Spitzmüller, Andreas Stamm, Serge Maximilian Sullivan, David J. Sullivan, William Suresh, Sundari Suzuki, Brian M. Suzuki, Yo Swamidass, S. Joshua Taramelli, Donatella Tchokouaha, Lauve R.Y. Theron, Anjo Thomas, David Tonissen, Kathryn F. Townson, Simon Tripathi, Abhai K. Trofimov, Valentin Udenze, Kenneth O. Ullah, Imran Vallieres, Cindy Vigil, Edgar Vinetz, Joseph M. Voong Vinh, Phat Vu, Hoan Watanabe, Nao-aki Weatherby, Kate White, Pamela M. Wilks, Andrew F. Winzeler, Elizabeth A. Wojcik, Edward Wree, Melanie Wu, Wesley Yokoyama, Naoaki Zollo, Paul H. A. Abla, Nada Blasco, Benjamin Burrows, Jeremy Laleu, Benoît Leroy, Didier Spangenberg, Thomas Wells, Timothy Willis, Paul A. A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still largely within industry. Open source drug discovery, with sharing of information, is clearly a first step towards overcoming this gap. But the interface could especially be bridged through a scale-up of open sharing of physical compounds, which would accelerate the finding of new starting points for drug discovery. The Medicines for Malaria Venture Malaria Box is a collection of over 400 compounds representing families of structures identified in phenotypic screens of pharmaceutical and academic libraries against the Plasmodium falciparum malaria parasite. The set has now been distributed to almost 200 research groups globally in the last two years, with the only stipulation that information from the screens is deposited in the public domain. This paper reports for the first time on 236 screens that have been carried out against the Malaria Box and compares these results with 55 assays that were previously published, in a format that allows a meta-analysis of the combined dataset. The combined biochemical and cellular assays presented here suggest mechanisms of action for 135 (34%) of the compounds active in killing multiple life-cycle stages of the malaria parasite, including asexual blood, liver, gametocyte, gametes and insect ookinete stages. In addition, many compounds demonstrated activity against other pathogens, showing hits in assays with 16 protozoa, 7 helminths, 9 bacterial and mycobacterial species, the dengue fever mosquito vector, and the NCI60 human cancer cell line panel of 60 human tumor cell lines. Toxicological, pharmacokinetic and metabolic properties were collected on all the compounds, assisting in the selection of the most promising candidates for murine proof-of-concept experiments and medicinal chemistry programs. The data for all of these assays are presented and analyzed to show how outstanding leads for many indications can be selected. These results reveal the immense potential for translating the dispersed expertise in biological assays involving human pathogens into drug discovery starting points, by providing open access to new families of molecules, and emphasize how a small additional investment made to help acquire and distribute compounds, and sharing the data, can catalyze drug discovery for dozens of different indications. Another lesson is that when multiple screens from different groups are run on the same library, results can be integrated quickly to select the most valuable starting points for subsequent medicinal chemistry efforts. Public Library of Science 2016-07-28 Article PeerReviewed Phillips, Margaret A., Van Voorhis, Wesley C., Adams, John H., Adelfio, Roberto, Ahyong, Vida, Akabas, Myles H., Alano, Pietro, Alday, Aintzane, Alemán Resto, Yesmalie, Alsibaee, Aishah, Alzualde, Ainhoa, Andrews, Katherine T., Avery, Simon V., Avery, Vicky M., Ayong, Lawrence, Baker, Mark, Baker, Stephen, Ben Mamoun, Choukri, Bhatia, Sangeeta, Bickle, Quentin, Bounaadja, Lotfi, Bowling, Tana, Bosch, Jürgen, Boucher, Lauren E., Boyom, Fabrice F., Brea, Jose, Brennan, Marian, Burton, Audrey, Caffrey, Conor R., Camarda, Grazia, Carrasquilla, Manuela, Carter, Dee, Belen Cassera, Maria, Chih-Chien Cheng, Ken, Chindaudomsate, Worathad, Chubb, Anthony, Colon, Beatrice L., Colón-López, Daisy D., Corbett, Yolanda, Crowther, Gregory J., Cowan, Noemi, D’Alessandro, Sarah, Le Dang, Na, Delves, Michael, DeRisi, Joseph L., Du, Alan Y., Duffy, Sandra, Abd El-Salam El-Sayed, Shimaa, Ferdig, Michael T., Fernández Robledo, José A., Fidock, David A., Florent, Isabelle, Fokou, Patrick V. T., Galstian, Ani, Gamo, Francisco Javier, Gokool, Suzanne, Gold, Ben, Golub, Todd, Goldgof, Gregory M., Guha, Rajarshi, Guiguemde, W. Armand, Gural, Nil, Guy, R. Kiplin, Hansen, Michael A. E., Hanson, Kirsten K., Hemphill, Andrew, Hooft van Huijsduijnen, Rob, Horii, Takaaki, Horrocks, Paul, Hughes, Tyler B., Huston, Christopher, Igarashi, Ikuo, Ingram-Sieber, Katrin, Itoe, Maurice A., Jadhav, Ajit, Naranuntarat Jensen, Amornrat, Jensen, Laran T., Jiang, Rays H.Y., Kaiser, Annette, Keiser, Jennifer, Ketas, Thomas, Kicka, Sebastien, Kim, Sunyoung, Kirk, Kiaran, Kumar, Vidya P., Kyle, Dennis E., Lafuente, Maria Jose, Landfear, Scott, Lee, Nathan, Lee, Sukjun, Lehane, Adele M., Li, Fengwu, Little, David, Liu, Liqiong, Llinás, Manuel, Loza, Maria I., Lubar, Aristea, Lucantoni, Leonardo, Lucet, Isabelle, Maes, Louis, Mancama, Dalu, Mansour, Nuha R., March, Sandra, McGowan, Sheena, Medina Vera, Iset, Meister, Stephan, Mercer, Luke, Mestres, Jordi, Mfopa, Alvine N., Misra, Raj N., Moon, Seunghyun, Moore, John P., Morais Rodrigues da Costa, Francielly, Müller, Joachim, Muriana, Arantza, Nakazawa Hewitt, Stephen, Nare, Bakela, Nathan, Carl, Narraidoo, Nathalie, Nawaratna, Sujeevi, Ojo, Kayode K., Ortiz, Diana, Panic, Gordana, Papadatos, George, Parapini, Silvia, Patra, Kailash, Pham, Ngoc, Prats, Sarah, Plouffe, David M., Poulsen, Sally-Ann, Pradhan, Anupam, Quevedo, Celia, Quinn, Ronald J., Rice, Christopher A., Abdo Rizk, Mohamed, Ruecker, Andrea, St. Onge, Robert, Salgado Ferreira, Rafaela, Samra, Jasmeet, Robinett, Natalie G., Schlecht, Ulrich, Schmitt, Marjorie, Silva Villela, Filipe, Silvestrini, Francesco, Sinden, Robert, Smith, Dennis A., Soldati, Thierry, Spitzmüller, Andreas, Stamm, Serge Maximilian, Sullivan, David J., Sullivan, William, Suresh, Sundari, Suzuki, Brian M., Suzuki, Yo, Swamidass, S. Joshua, Taramelli, Donatella, Tchokouaha, Lauve R.Y., Theron, Anjo, Thomas, David, Tonissen, Kathryn F., Townson, Simon, Tripathi, Abhai K., Trofimov, Valentin, Udenze, Kenneth O., Ullah, Imran, Vallieres, Cindy, Vigil, Edgar, Vinetz, Joseph M., Voong Vinh, Phat, Vu, Hoan, Watanabe, Nao-aki, Weatherby, Kate, White, Pamela M., Wilks, Andrew F., Winzeler, Elizabeth A., Wojcik, Edward, Wree, Melanie, Wu, Wesley, Yokoyama, Naoaki, Zollo, Paul H. A., Abla, Nada, Blasco, Benjamin, Burrows, Jeremy, Laleu, Benoît, Leroy, Didier, Spangenberg, Thomas, Wells, Timothy and Willis, Paul A. (2016) Open source drug discovery with the Malaria Box Compound collection for neglected diseases and beyond. PLOS Pathogens, 12 (7). e1005763/1-e1005763/23. ISSN 1553-7374 http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005763 doi:10.1371/journal.ppat.1005763 doi:10.1371/journal.ppat.1005763 |
| spellingShingle | Phillips, Margaret A. Van Voorhis, Wesley C. Adams, John H. Adelfio, Roberto Ahyong, Vida Akabas, Myles H. Alano, Pietro Alday, Aintzane Alemán Resto, Yesmalie Alsibaee, Aishah Alzualde, Ainhoa Andrews, Katherine T. Avery, Simon V. Avery, Vicky M. Ayong, Lawrence Baker, Mark Baker, Stephen Ben Mamoun, Choukri Bhatia, Sangeeta Bickle, Quentin Bounaadja, Lotfi Bowling, Tana Bosch, Jürgen Boucher, Lauren E. Boyom, Fabrice F. Brea, Jose Brennan, Marian Burton, Audrey Caffrey, Conor R. Camarda, Grazia Carrasquilla, Manuela Carter, Dee Belen Cassera, Maria Chih-Chien Cheng, Ken Chindaudomsate, Worathad Chubb, Anthony Colon, Beatrice L. Colón-López, Daisy D. Corbett, Yolanda Crowther, Gregory J. Cowan, Noemi D’Alessandro, Sarah Le Dang, Na Delves, Michael DeRisi, Joseph L. Du, Alan Y. Duffy, Sandra Abd El-Salam El-Sayed, Shimaa Ferdig, Michael T. Fernández Robledo, José A. Fidock, David A. Florent, Isabelle Fokou, Patrick V. T. Galstian, Ani Gamo, Francisco Javier Gokool, Suzanne Gold, Ben Golub, Todd Goldgof, Gregory M. Guha, Rajarshi Guiguemde, W. Armand Gural, Nil Guy, R. Kiplin Hansen, Michael A. E. Hanson, Kirsten K. Hemphill, Andrew Hooft van Huijsduijnen, Rob Horii, Takaaki Horrocks, Paul Hughes, Tyler B. Huston, Christopher Igarashi, Ikuo Ingram-Sieber, Katrin Itoe, Maurice A. Jadhav, Ajit Naranuntarat Jensen, Amornrat Jensen, Laran T. Jiang, Rays H.Y. Kaiser, Annette Keiser, Jennifer Ketas, Thomas Kicka, Sebastien Kim, Sunyoung Kirk, Kiaran Kumar, Vidya P. Kyle, Dennis E. Lafuente, Maria Jose Landfear, Scott Lee, Nathan Lee, Sukjun Lehane, Adele M. Li, Fengwu Little, David Liu, Liqiong Llinás, Manuel Loza, Maria I. Lubar, Aristea Lucantoni, Leonardo Lucet, Isabelle Maes, Louis Mancama, Dalu Mansour, Nuha R. March, Sandra McGowan, Sheena Medina Vera, Iset Meister, Stephan Mercer, Luke Mestres, Jordi Mfopa, Alvine N. Misra, Raj N. Moon, Seunghyun Moore, John P. Morais Rodrigues da Costa, Francielly Müller, Joachim Muriana, Arantza Nakazawa Hewitt, Stephen Nare, Bakela Nathan, Carl Narraidoo, Nathalie Nawaratna, Sujeevi Ojo, Kayode K. Ortiz, Diana Panic, Gordana Papadatos, George Parapini, Silvia Patra, Kailash Pham, Ngoc Prats, Sarah Plouffe, David M. Poulsen, Sally-Ann Pradhan, Anupam Quevedo, Celia Quinn, Ronald J. Rice, Christopher A. Abdo Rizk, Mohamed Ruecker, Andrea St. Onge, Robert Salgado Ferreira, Rafaela Samra, Jasmeet Robinett, Natalie G. Schlecht, Ulrich Schmitt, Marjorie Silva Villela, Filipe Silvestrini, Francesco Sinden, Robert Smith, Dennis A. Soldati, Thierry Spitzmüller, Andreas Stamm, Serge Maximilian Sullivan, David J. Sullivan, William Suresh, Sundari Suzuki, Brian M. Suzuki, Yo Swamidass, S. Joshua Taramelli, Donatella Tchokouaha, Lauve R.Y. Theron, Anjo Thomas, David Tonissen, Kathryn F. Townson, Simon Tripathi, Abhai K. Trofimov, Valentin Udenze, Kenneth O. Ullah, Imran Vallieres, Cindy Vigil, Edgar Vinetz, Joseph M. Voong Vinh, Phat Vu, Hoan Watanabe, Nao-aki Weatherby, Kate White, Pamela M. Wilks, Andrew F. Winzeler, Elizabeth A. Wojcik, Edward Wree, Melanie Wu, Wesley Yokoyama, Naoaki Zollo, Paul H. A. Abla, Nada Blasco, Benjamin Burrows, Jeremy Laleu, Benoît Leroy, Didier Spangenberg, Thomas Wells, Timothy Willis, Paul A. Open source drug discovery with the Malaria Box Compound collection for neglected diseases and beyond |
| title | Open source drug discovery with the Malaria Box Compound collection for neglected diseases and beyond |
| title_full | Open source drug discovery with the Malaria Box Compound collection for neglected diseases and beyond |
| title_fullStr | Open source drug discovery with the Malaria Box Compound collection for neglected diseases and beyond |
| title_full_unstemmed | Open source drug discovery with the Malaria Box Compound collection for neglected diseases and beyond |
| title_short | Open source drug discovery with the Malaria Box Compound collection for neglected diseases and beyond |
| title_sort | open source drug discovery with the malaria box compound collection for neglected diseases and beyond |
| url | https://eprints.nottingham.ac.uk/37733/ https://eprints.nottingham.ac.uk/37733/ https://eprints.nottingham.ac.uk/37733/ |