Glutamine supplementation in cystic fibrosis: a randomized placebo-controlled trial
Rationale: Pulmonary infection and malnutrition in cystic fibrosis are associated with decreased survival. Glutamine has a possible anti-microbial effect, with a specific impact against Pseudomonas aeruginosa. We aimed to test the hypothesis that oral glutamine supplementation (21 g/day) for 8 weeks...
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| Format: | Article |
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Wiley
2015
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| Online Access: | https://eprints.nottingham.ac.uk/37727/ |
| _version_ | 1848795520996212736 |
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| author | Forrester, Doug L. Knox, Alan J. Smyth, Alan R. Barr, Helen L. Simms, Rebecca Pacey, Sarah J. Pavord, Ian D. Honeybourne, David Dewar, Jane Clayton, Andy Fogarty, Andrew W. |
| author_facet | Forrester, Doug L. Knox, Alan J. Smyth, Alan R. Barr, Helen L. Simms, Rebecca Pacey, Sarah J. Pavord, Ian D. Honeybourne, David Dewar, Jane Clayton, Andy Fogarty, Andrew W. |
| author_sort | Forrester, Doug L. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Rationale: Pulmonary infection and malnutrition in cystic fibrosis are associated with decreased survival. Glutamine has a possible anti-microbial effect, with a specific impact against Pseudomonas aeruginosa. We aimed to test the hypothesis that oral glutamine supplementation (21 g/day) for 8 weeks in adults with cystic fibrosis would decrease pulmonary inflammation and improve clinical status.
Methods: The study design was a randomized double-blind placebo-controlled study design with an iso-nitrogenous placebo. The primary analysis was intention to treat, and the primary outcome was change in induced sputum neutrophils.
Results: Thirty-nine individuals were recruited and thirty-six completed the study. Glutamine supplementation had no impact on any of the outcome measures in the intention-to-treat analysis. In the per protocol analysis, glutamine supplementation was associated with an increase in induced sputum neutrophils (P = 0.046), total cells (P = 0.03), and in Pseudomonas isolation agar colony forming units (P = 0.04) compared to placebo.
Conclusions: There was no effect of glutamine supplementation on markers of pulmonary inflammation in the intention-to-treat analysis. |
| first_indexed | 2025-11-14T19:33:24Z |
| format | Article |
| id | nottingham-37727 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:33:24Z |
| publishDate | 2015 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-377272020-05-04T17:25:46Z https://eprints.nottingham.ac.uk/37727/ Glutamine supplementation in cystic fibrosis: a randomized placebo-controlled trial Forrester, Doug L. Knox, Alan J. Smyth, Alan R. Barr, Helen L. Simms, Rebecca Pacey, Sarah J. Pavord, Ian D. Honeybourne, David Dewar, Jane Clayton, Andy Fogarty, Andrew W. Rationale: Pulmonary infection and malnutrition in cystic fibrosis are associated with decreased survival. Glutamine has a possible anti-microbial effect, with a specific impact against Pseudomonas aeruginosa. We aimed to test the hypothesis that oral glutamine supplementation (21 g/day) for 8 weeks in adults with cystic fibrosis would decrease pulmonary inflammation and improve clinical status. Methods: The study design was a randomized double-blind placebo-controlled study design with an iso-nitrogenous placebo. The primary analysis was intention to treat, and the primary outcome was change in induced sputum neutrophils. Results: Thirty-nine individuals were recruited and thirty-six completed the study. Glutamine supplementation had no impact on any of the outcome measures in the intention-to-treat analysis. In the per protocol analysis, glutamine supplementation was associated with an increase in induced sputum neutrophils (P = 0.046), total cells (P = 0.03), and in Pseudomonas isolation agar colony forming units (P = 0.04) compared to placebo. Conclusions: There was no effect of glutamine supplementation on markers of pulmonary inflammation in the intention-to-treat analysis. Wiley 2015-12-27 Article PeerReviewed Forrester, Doug L., Knox, Alan J., Smyth, Alan R., Barr, Helen L., Simms, Rebecca, Pacey, Sarah J., Pavord, Ian D., Honeybourne, David, Dewar, Jane, Clayton, Andy and Fogarty, Andrew W. (2015) Glutamine supplementation in cystic fibrosis: a randomized placebo-controlled trial. Pediatric Pulmonology, 51 (3). pp. 253-257. ISSN 1099-0496 glutamine cystic fibrosis infection nutrition http://onlinelibrary.wiley.com/doi/10.1002/ppul.23370/abstract doi:10.1002/ppul.23370 doi:10.1002/ppul.23370 |
| spellingShingle | glutamine cystic fibrosis infection nutrition Forrester, Doug L. Knox, Alan J. Smyth, Alan R. Barr, Helen L. Simms, Rebecca Pacey, Sarah J. Pavord, Ian D. Honeybourne, David Dewar, Jane Clayton, Andy Fogarty, Andrew W. Glutamine supplementation in cystic fibrosis: a randomized placebo-controlled trial |
| title | Glutamine supplementation in cystic fibrosis: a randomized placebo-controlled trial |
| title_full | Glutamine supplementation in cystic fibrosis: a randomized placebo-controlled trial |
| title_fullStr | Glutamine supplementation in cystic fibrosis: a randomized placebo-controlled trial |
| title_full_unstemmed | Glutamine supplementation in cystic fibrosis: a randomized placebo-controlled trial |
| title_short | Glutamine supplementation in cystic fibrosis: a randomized placebo-controlled trial |
| title_sort | glutamine supplementation in cystic fibrosis: a randomized placebo-controlled trial |
| topic | glutamine cystic fibrosis infection nutrition |
| url | https://eprints.nottingham.ac.uk/37727/ https://eprints.nottingham.ac.uk/37727/ https://eprints.nottingham.ac.uk/37727/ |