The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals
The development of fetal ovarian follicles is a critical determinant of adult female reproductive competence. Prolonged exposure to environmental chemicals (ECs) can perturb this process with detrimental consequences for offspring. Here we report on the exposure of pregnant ewes to an environmental...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
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Nature Publishing Group
2016
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| Online Access: | https://eprints.nottingham.ac.uk/37660/ |
| _version_ | 1848795505518182400 |
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| author | Leach, Richard G. Amezaga, Maria R. Loup, Benoit Mandon-Pépin, Béatrice Stefansdottir, Agnes Filis, Panagiotis Kyle, Carol Zhang, Zulin Allen, Ceri E. Purdie, Laura Jouneau, Luc Cotinot, Corinne Rhind, Stewart M. Sinclair, Kevin D. Fowler, Paul A. |
| author_facet | Leach, Richard G. Amezaga, Maria R. Loup, Benoit Mandon-Pépin, Béatrice Stefansdottir, Agnes Filis, Panagiotis Kyle, Carol Zhang, Zulin Allen, Ceri E. Purdie, Laura Jouneau, Luc Cotinot, Corinne Rhind, Stewart M. Sinclair, Kevin D. Fowler, Paul A. |
| author_sort | Leach, Richard G. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The development of fetal ovarian follicles is a critical determinant of adult female reproductive competence. Prolonged exposure to environmental chemicals (ECs) can perturb this process with detrimental consequences for offspring. Here we report on the exposure of pregnant ewes to an environmental mixture of ECs derived from pastures fertilized with sewage sludge (biosolids): a common global agricultural practice. Exposure of pregnant ewes to ECs over 80 day periods during early, mid or late gestation reduced the proportion of healthy early stage fetal follicles comprising the ovarian reserve. Mid and late gestation EC exposures had the most marked effects, disturbing maternal and fetal liver chemical profiles, masculinising fetal anogenital distance and greatly increasing the number of altered fetal ovarian genes and proteins. In conclusion, differential temporal sensitivity of the fetus and its ovaries to EC mixtures has implications for adult ovarian function following adverse exposures during pregnancy. |
| first_indexed | 2025-11-14T19:33:09Z |
| format | Article |
| id | nottingham-37660 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:33:09Z |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-376602020-05-04T17:43:12Z https://eprints.nottingham.ac.uk/37660/ The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals Leach, Richard G. Amezaga, Maria R. Loup, Benoit Mandon-Pépin, Béatrice Stefansdottir, Agnes Filis, Panagiotis Kyle, Carol Zhang, Zulin Allen, Ceri E. Purdie, Laura Jouneau, Luc Cotinot, Corinne Rhind, Stewart M. Sinclair, Kevin D. Fowler, Paul A. The development of fetal ovarian follicles is a critical determinant of adult female reproductive competence. Prolonged exposure to environmental chemicals (ECs) can perturb this process with detrimental consequences for offspring. Here we report on the exposure of pregnant ewes to an environmental mixture of ECs derived from pastures fertilized with sewage sludge (biosolids): a common global agricultural practice. Exposure of pregnant ewes to ECs over 80 day periods during early, mid or late gestation reduced the proportion of healthy early stage fetal follicles comprising the ovarian reserve. Mid and late gestation EC exposures had the most marked effects, disturbing maternal and fetal liver chemical profiles, masculinising fetal anogenital distance and greatly increasing the number of altered fetal ovarian genes and proteins. In conclusion, differential temporal sensitivity of the fetus and its ovaries to EC mixtures has implications for adult ovarian function following adverse exposures during pregnancy. Nature Publishing Group 2016-03-02 Article PeerReviewed Leach, Richard G., Amezaga, Maria R., Loup, Benoit, Mandon-Pépin, Béatrice, Stefansdottir, Agnes, Filis, Panagiotis, Kyle, Carol, Zhang, Zulin, Allen, Ceri E., Purdie, Laura, Jouneau, Luc, Cotinot, Corinne, Rhind, Stewart M., Sinclair, Kevin D. and Fowler, Paul A. (2016) The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals. Scientific Reports, 6 . 22279/1-22279/13. ISSN 2045-2322 http://www.nature.com/articles/srep22279 doi:10.1038/srep22279 doi:10.1038/srep22279 |
| spellingShingle | Leach, Richard G. Amezaga, Maria R. Loup, Benoit Mandon-Pépin, Béatrice Stefansdottir, Agnes Filis, Panagiotis Kyle, Carol Zhang, Zulin Allen, Ceri E. Purdie, Laura Jouneau, Luc Cotinot, Corinne Rhind, Stewart M. Sinclair, Kevin D. Fowler, Paul A. The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals |
| title | The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals |
| title_full | The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals |
| title_fullStr | The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals |
| title_full_unstemmed | The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals |
| title_short | The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals |
| title_sort | fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals |
| url | https://eprints.nottingham.ac.uk/37660/ https://eprints.nottingham.ac.uk/37660/ https://eprints.nottingham.ac.uk/37660/ |