Separating chemotherapy-related developmental neurotoxicity from cytotoxicity in monolayer and neurosphere cultures of human fetal brain cells

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Separating chemotherapy-related developmental neurotoxicity from cytotoxicity in monolayer and neurosphere cultures of human fetal brain cells

Chemotherapy-induced neurotoxicity can reduce the quality of life of patients by affecting their intelligence, senses and mobility. Ten percent of safety-related late-stage clinical failures are due to neurological side effects. Animal models are poor in predicting human neurotoxicity due to intersp...

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Bibliographic Details
Main Authors:	Ivanov, Delyan P., Al-Rubai, Abdal-jabbar, Grabowska, Anna M., Pratten, Margaret K.
Format:	Article
Published:	Elsevier 2016
Subjects:	Neural stem cell; preclinical screening model; in vitro neurotoxicity assay; neuronal differentiation; topoisomerase drugs; repurposing chemotherapeutics
Online Access:	https://eprints.nottingham.ac.uk/37657/

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