Arginine dependence of acute myeloid leukaemia blast proliferation: a novel therapeutic target

Arginine dependence of acute myeloid leukaemia blast proliferation: a novel therapeutic target

Acute myeloid leukemia (AML) is one of the most common acute leukemias in adults and children, yet significant numbers of patients relapse and die of disease. In this study, we identify the dependence of AML blasts on arginine for proliferation. We show that AML blasts constitutively express the arg...

Full description

Bibliographic Details
Main Authors: Mussai, Francis, Egan, Sharon A., Higginbotham-Jones, Joseph, Perry, Tracey, Beggs, Andrew, Odintsova, Elena, Loke, Justin, Pratt, Guy, Pong U, Kin, Lo, Anthony, Ng, Margaret, Kearns, Pamela R., Cheng, Paul, De Santo, Carmela
Format: Article
Published: American Society of Hematology 2015
Subjects:
Arginase depletion
BCT-100 pegylated recombinant human arginase
AML blasts
Online Access:https://eprints.nottingham.ac.uk/37630/

Internet

https://eprints.nottingham.ac.uk/37630/

Similar Items