Real time Raman imaging to understand dissolution performance of amorphous solid dispersions

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Real time Raman imaging to understand dissolution performance of amorphous solid dispersions

We have employed for the first time Raman spectroscopic imaging along with multi-variate curve resolution (MCR) analysis to investigate in real time and in-situ the dissolution mechanisms that underpin amorphous solid dispersions, with data being collected directly from the dosage form itself. We ha...

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Bibliographic Details
Main Authors:	Tres, Francesco, Treacher, Kevin, Booth, Jonathan, Hughes, Les P., Wren, Stephen A.C., Aylott, Jonathan W., Burley, Jonathan C.
Format:	Article
Published:	Elsevier 2014
Subjects:	Poorly soluble drugs; Amorphous solid dispersions; Solid-state transformations; Raman imaging; Intrinsic dissolution rate; Multi-variate curve resolution (MCR)
Online Access:	https://eprints.nottingham.ac.uk/37564/

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