PEGylation of paclitaxel largely improves its safety and anti-tumor efficacy following pulmonary delivery in a mouse model of lung carcinoma

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PEGylation of paclitaxel largely improves its safety and anti-tumor efficacy following pulmonary delivery in a mouse model of lung carcinoma

Pulmonary delivery offers an attractive route of administration for chemotherapeutic agents, with the advantages of high drug concentrations locally and low side effects systemically. However, fast clearance mechanisms result in short residence time of small molecule drugs in the lungs. Moreover, th...

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Bibliographic Details
Main Authors:	Luo, Tian, Loira-Pastoriza, Cristina, Patil, Harshad P., Ucakar, Bernard, Muccioli, Giulio G., Bosquillon, Cynthia, Vanbever, Rita
Format:	Article
Published:	Elsevier 2016
Subjects:	Polymer-drug conjugates; Inhaled chemotherapy; Lung cancer; Pulmonary delivery; Paclitaxel; Prodrug
Online Access:	https://eprints.nottingham.ac.uk/37380/

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