Gelation properties of self-assembling N-acyl modified cytidine derivatives
In this study we report the synthesis of new cytidine derived gelators possessing acyl chains of different lengths. These low molecular weight gelators were shown to form self-supporting gels at 0.5 % (w/v) in binary systems of aqueous miscible polar organic solvent and water. The representative gel...
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| Format: | Article |
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Royal Society of Chemistry
2014
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| Online Access: | https://eprints.nottingham.ac.uk/37331/ |
| _version_ | 1848795437520125952 |
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| author | Skilling, Kathryn J. Ndungu, A. Kellam, Barrie Ashford, M. Bradshaw, Tracey D. Marlow, Maria |
| author_facet | Skilling, Kathryn J. Ndungu, A. Kellam, Barrie Ashford, M. Bradshaw, Tracey D. Marlow, Maria |
| author_sort | Skilling, Kathryn J. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | In this study we report the synthesis of new cytidine derived gelators possessing acyl chains of different lengths. These low molecular weight gelators were shown to form self-supporting gels at 0.5 % (w/v) in binary systems of aqueous miscible polar organic solvent and water. The representative gels were studied using rheology and their fibrillar structure confirmed by TEM imaging and FTIR. We further demonstrated the use of these gels as potential drug delivery platforms by monitoring release characteristics of both high and low molecular weight fluorescently labelled tracers. |
| first_indexed | 2025-11-14T19:32:04Z |
| format | Article |
| id | nottingham-37331 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:32:04Z |
| publishDate | 2014 |
| publisher | Royal Society of Chemistry |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-373312020-05-04T16:55:19Z https://eprints.nottingham.ac.uk/37331/ Gelation properties of self-assembling N-acyl modified cytidine derivatives Skilling, Kathryn J. Ndungu, A. Kellam, Barrie Ashford, M. Bradshaw, Tracey D. Marlow, Maria In this study we report the synthesis of new cytidine derived gelators possessing acyl chains of different lengths. These low molecular weight gelators were shown to form self-supporting gels at 0.5 % (w/v) in binary systems of aqueous miscible polar organic solvent and water. The representative gels were studied using rheology and their fibrillar structure confirmed by TEM imaging and FTIR. We further demonstrated the use of these gels as potential drug delivery platforms by monitoring release characteristics of both high and low molecular weight fluorescently labelled tracers. Royal Society of Chemistry 2014-10-22 Article PeerReviewed Skilling, Kathryn J., Ndungu, A., Kellam, Barrie, Ashford, M., Bradshaw, Tracey D. and Marlow, Maria (2014) Gelation properties of self-assembling N-acyl modified cytidine derivatives. Journal of Materials Chemistry B, 2 (47). pp. 8412-8417. ISSN 2050-750X http://pubs.rsc.org/en/Content/ArticleLanding/2014/TB/C4TB01375A#!divAbstract doi:10.1039/C4TB01375A doi:10.1039/C4TB01375A |
| spellingShingle | Skilling, Kathryn J. Ndungu, A. Kellam, Barrie Ashford, M. Bradshaw, Tracey D. Marlow, Maria Gelation properties of self-assembling N-acyl modified cytidine derivatives |
| title | Gelation properties of self-assembling N-acyl modified cytidine derivatives |
| title_full | Gelation properties of self-assembling N-acyl modified cytidine derivatives |
| title_fullStr | Gelation properties of self-assembling N-acyl modified cytidine derivatives |
| title_full_unstemmed | Gelation properties of self-assembling N-acyl modified cytidine derivatives |
| title_short | Gelation properties of self-assembling N-acyl modified cytidine derivatives |
| title_sort | gelation properties of self-assembling n-acyl modified cytidine derivatives |
| url | https://eprints.nottingham.ac.uk/37331/ https://eprints.nottingham.ac.uk/37331/ https://eprints.nottingham.ac.uk/37331/ |