Developing a self-healing supramolecular nucleoside hydrogel
Low molecular weight gelator hydrogels provide a viable alternative to traditional polymer based drug delivery platforms, owing to their tunable stability and in most cases inherent biocompatibility. Here we report the first self-healing nucleoside hydrogel using N4-octanoyl-2′-deoxycytidine (0.5% w...
| Main Authors: | , , , , |
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| Format: | Article |
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Royal Society of Chemistry
2016
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| Online Access: | https://eprints.nottingham.ac.uk/37330/ |
| _version_ | 1848795437261127680 |
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| author | Skilling, Kathryn J. Kellam, Barrie Ashford, M. Bradshaw, Tracey D. Marlow, Maria |
| author_facet | Skilling, Kathryn J. Kellam, Barrie Ashford, M. Bradshaw, Tracey D. Marlow, Maria |
| author_sort | Skilling, Kathryn J. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Low molecular weight gelator hydrogels provide a viable alternative to traditional polymer based drug delivery platforms, owing to their tunable stability and in most cases inherent biocompatibility. Here we report the first self-healing nucleoside hydrogel using N4-octanoyl-2′-deoxycytidine (0.5% w/v) for drug delivery. The hydrogel's cross-linked nanofibrillar structure, was characterised using oscillatory rheology and confirmed using SEM and TEM imaging. The potential of this gel for drug delivery was explored in vitro using fluorescently labelled tracers. Cell viability assays were conducted using pancreatic cell lines which tolerated the gels well; whilst no adverse effects on the viability or proliferation of cells were observed for fibroblast cell lines. |
| first_indexed | 2025-11-14T19:32:04Z |
| format | Article |
| id | nottingham-37330 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:32:04Z |
| publishDate | 2016 |
| publisher | Royal Society of Chemistry |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-373302020-05-04T18:10:21Z https://eprints.nottingham.ac.uk/37330/ Developing a self-healing supramolecular nucleoside hydrogel Skilling, Kathryn J. Kellam, Barrie Ashford, M. Bradshaw, Tracey D. Marlow, Maria Low molecular weight gelator hydrogels provide a viable alternative to traditional polymer based drug delivery platforms, owing to their tunable stability and in most cases inherent biocompatibility. Here we report the first self-healing nucleoside hydrogel using N4-octanoyl-2′-deoxycytidine (0.5% w/v) for drug delivery. The hydrogel's cross-linked nanofibrillar structure, was characterised using oscillatory rheology and confirmed using SEM and TEM imaging. The potential of this gel for drug delivery was explored in vitro using fluorescently labelled tracers. Cell viability assays were conducted using pancreatic cell lines which tolerated the gels well; whilst no adverse effects on the viability or proliferation of cells were observed for fibroblast cell lines. Royal Society of Chemistry 2016-09-21 Article PeerReviewed Skilling, Kathryn J., Kellam, Barrie, Ashford, M., Bradshaw, Tracey D. and Marlow, Maria (2016) Developing a self-healing supramolecular nucleoside hydrogel. Soft Matter . ISSN 1744-6848 http://pubs.rsc.org/en/Content/ArticleLanding/2016/SM/C6SM01779G#!divAbstract doi:10.1039/C6SM01779G doi:10.1039/C6SM01779G |
| spellingShingle | Skilling, Kathryn J. Kellam, Barrie Ashford, M. Bradshaw, Tracey D. Marlow, Maria Developing a self-healing supramolecular nucleoside hydrogel |
| title | Developing a self-healing supramolecular nucleoside hydrogel |
| title_full | Developing a self-healing supramolecular nucleoside hydrogel |
| title_fullStr | Developing a self-healing supramolecular nucleoside hydrogel |
| title_full_unstemmed | Developing a self-healing supramolecular nucleoside hydrogel |
| title_short | Developing a self-healing supramolecular nucleoside hydrogel |
| title_sort | developing a self-healing supramolecular nucleoside hydrogel |
| url | https://eprints.nottingham.ac.uk/37330/ https://eprints.nottingham.ac.uk/37330/ https://eprints.nottingham.ac.uk/37330/ |