The influence of nanotexturing of poly(lactic-co-glycolic acid) films upon human ovarian cancer cell attachment
In this study, we have produced nanotextured poly(lactic-co-glycolic acid) (PLGA) films by using polystyrene (PS) particles as a template to make a polydimethylsiloxane mould against which PLGA is solvent cast. Biocompatible, biodegradable and nanotextured PLGA films were prepared with PS particles...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Published: |
IOP Publishing
2016
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/37328/ |
| _version_ | 1848795436952846336 |
|---|---|
| author | Yaşayan, Gökçen Xue, Xuan Collier, Pamela Clarke, Philip Alexander, Morgan R. Marlow, Maria |
| author_facet | Yaşayan, Gökçen Xue, Xuan Collier, Pamela Clarke, Philip Alexander, Morgan R. Marlow, Maria |
| author_sort | Yaşayan, Gökçen |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | In this study, we have produced nanotextured poly(lactic-co-glycolic acid) (PLGA) films by using polystyrene (PS) particles as a template to make a polydimethylsiloxane mould against which PLGA is solvent cast. Biocompatible, biodegradable and nanotextured PLGA films were prepared with PS particles of diameter of 57, 99, 210, and 280 nm that produced domes of the same dimension in the PLGA surface. The effect of the particulate monolayer templating method was investigated to enable preparation of the films with uniformly ordered surface nanodomes. Cell attachment of a human ovarian cancer cell line (OVCAR3) alone and co-cultured with mesenchymal stem cells (MSCs) was evaluated on flat and topographically nano-patterned surfaces. Cell numbers were observed to increase on the nanotextured surfaces compared to non-textured surfaces both with OVCAR3 cultures and OVCAR3-MSC co-cultures at 24 and 48 h time points. |
| first_indexed | 2025-11-14T19:32:04Z |
| format | Article |
| id | nottingham-37328 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:32:04Z |
| publishDate | 2016 |
| publisher | IOP Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-373282020-05-04T17:51:40Z https://eprints.nottingham.ac.uk/37328/ The influence of nanotexturing of poly(lactic-co-glycolic acid) films upon human ovarian cancer cell attachment Yaşayan, Gökçen Xue, Xuan Collier, Pamela Clarke, Philip Alexander, Morgan R. Marlow, Maria In this study, we have produced nanotextured poly(lactic-co-glycolic acid) (PLGA) films by using polystyrene (PS) particles as a template to make a polydimethylsiloxane mould against which PLGA is solvent cast. Biocompatible, biodegradable and nanotextured PLGA films were prepared with PS particles of diameter of 57, 99, 210, and 280 nm that produced domes of the same dimension in the PLGA surface. The effect of the particulate monolayer templating method was investigated to enable preparation of the films with uniformly ordered surface nanodomes. Cell attachment of a human ovarian cancer cell line (OVCAR3) alone and co-cultured with mesenchymal stem cells (MSCs) was evaluated on flat and topographically nano-patterned surfaces. Cell numbers were observed to increase on the nanotextured surfaces compared to non-textured surfaces both with OVCAR3 cultures and OVCAR3-MSC co-cultures at 24 and 48 h time points. IOP Publishing 2016-05-17 Article PeerReviewed Yaşayan, Gökçen, Xue, Xuan, Collier, Pamela, Clarke, Philip, Alexander, Morgan R. and Marlow, Maria (2016) The influence of nanotexturing of poly(lactic-co-glycolic acid) films upon human ovarian cancer cell attachment. Nanotechnology, 27 (25). p. 255102. ISSN 1361-6528 nanotexturing films poly(lactic-co-glycolic acid) human ovarian cancer cell http://iopscience.iop.org/article/10.1088/0957-4484/27/25/255102/meta doi:10.1088/0957-4484/27/25/255102 doi:10.1088/0957-4484/27/25/255102 |
| spellingShingle | nanotexturing films poly(lactic-co-glycolic acid) human ovarian cancer cell Yaşayan, Gökçen Xue, Xuan Collier, Pamela Clarke, Philip Alexander, Morgan R. Marlow, Maria The influence of nanotexturing of poly(lactic-co-glycolic acid) films upon human ovarian cancer cell attachment |
| title | The influence of nanotexturing of poly(lactic-co-glycolic acid) films upon human ovarian cancer cell attachment |
| title_full | The influence of nanotexturing of poly(lactic-co-glycolic acid) films upon human ovarian cancer cell attachment |
| title_fullStr | The influence of nanotexturing of poly(lactic-co-glycolic acid) films upon human ovarian cancer cell attachment |
| title_full_unstemmed | The influence of nanotexturing of poly(lactic-co-glycolic acid) films upon human ovarian cancer cell attachment |
| title_short | The influence of nanotexturing of poly(lactic-co-glycolic acid) films upon human ovarian cancer cell attachment |
| title_sort | influence of nanotexturing of poly(lactic-co-glycolic acid) films upon human ovarian cancer cell attachment |
| topic | nanotexturing films poly(lactic-co-glycolic acid) human ovarian cancer cell |
| url | https://eprints.nottingham.ac.uk/37328/ https://eprints.nottingham.ac.uk/37328/ https://eprints.nottingham.ac.uk/37328/ |