Co-infection and emergence of rifamycin resistance during a recurrent Clostridium difficile infection
Clostridium difficile (Peptoclostridium difficile) is a common health care-associated infection with a disproportionately high incidence in elderly patients. Disease symptoms range from mild diarrhea to life-threatening pseudomembranous colitis. Around 20% of patients may suffer recurrent disease, w...
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| Format: | Article |
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American Society for Microbiology
2016
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| Online Access: | https://eprints.nottingham.ac.uk/37306/ |
| _version_ | 1848795430801899520 |
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| author | Stevenson, Emma C. Major, Giles A. Spiller, Robin C. Kuehne, Sarah A. Minton, Nigel P. |
| author_facet | Stevenson, Emma C. Major, Giles A. Spiller, Robin C. Kuehne, Sarah A. Minton, Nigel P. |
| author_sort | Stevenson, Emma C. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Clostridium difficile (Peptoclostridium difficile) is a common health care-associated infection with a disproportionately high incidence in elderly patients. Disease symptoms range from mild diarrhea to life-threatening pseudomembranous colitis. Around 20% of patients may suffer recurrent disease, which often requires rehospitalization of patients. C. difficile was isolated from stool samples from a patient with two recurrent C. difficile infections. PCR ribotyping, whole-genome sequencing, and phenotypic assays were used to characterize these isolates. Genotypic and phenotypic screening of C. difficile isolates revealed multiple PCR ribotypes present and the emergence of rifamycin resistance during the infection cycle. Understanding both the clinical and bacterial factors that contribute to the course of recurrent infection could inform strategies to reduce recurrence. (This study has been registered at ClinicalTrials.gov under registration no. NCT01670149.) |
| first_indexed | 2025-11-14T19:31:58Z |
| format | Article |
| id | nottingham-37306 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:31:58Z |
| publishDate | 2016 |
| publisher | American Society for Microbiology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-373062020-05-04T18:21:09Z https://eprints.nottingham.ac.uk/37306/ Co-infection and emergence of rifamycin resistance during a recurrent Clostridium difficile infection Stevenson, Emma C. Major, Giles A. Spiller, Robin C. Kuehne, Sarah A. Minton, Nigel P. Clostridium difficile (Peptoclostridium difficile) is a common health care-associated infection with a disproportionately high incidence in elderly patients. Disease symptoms range from mild diarrhea to life-threatening pseudomembranous colitis. Around 20% of patients may suffer recurrent disease, which often requires rehospitalization of patients. C. difficile was isolated from stool samples from a patient with two recurrent C. difficile infections. PCR ribotyping, whole-genome sequencing, and phenotypic assays were used to characterize these isolates. Genotypic and phenotypic screening of C. difficile isolates revealed multiple PCR ribotypes present and the emergence of rifamycin resistance during the infection cycle. Understanding both the clinical and bacterial factors that contribute to the course of recurrent infection could inform strategies to reduce recurrence. (This study has been registered at ClinicalTrials.gov under registration no. NCT01670149.) American Society for Microbiology 2016-11-15 Article PeerReviewed Stevenson, Emma C., Major, Giles A., Spiller, Robin C., Kuehne, Sarah A. and Minton, Nigel P. (2016) Co-infection and emergence of rifamycin resistance during a recurrent Clostridium difficile infection. Journal of Clinical Microbiology, 54 (11). pp. 2689-2694. ISSN 1098-660X http://jcm.asm.org/content/54/11/2689 doi:10.1128/JCM.01025-16 doi:10.1128/JCM.01025-16 |
| spellingShingle | Stevenson, Emma C. Major, Giles A. Spiller, Robin C. Kuehne, Sarah A. Minton, Nigel P. Co-infection and emergence of rifamycin resistance during a recurrent Clostridium difficile infection |
| title | Co-infection and emergence of rifamycin resistance during a recurrent Clostridium difficile infection |
| title_full | Co-infection and emergence of rifamycin resistance during a recurrent Clostridium difficile infection |
| title_fullStr | Co-infection and emergence of rifamycin resistance during a recurrent Clostridium difficile infection |
| title_full_unstemmed | Co-infection and emergence of rifamycin resistance during a recurrent Clostridium difficile infection |
| title_short | Co-infection and emergence of rifamycin resistance during a recurrent Clostridium difficile infection |
| title_sort | co-infection and emergence of rifamycin resistance during a recurrent clostridium difficile infection |
| url | https://eprints.nottingham.ac.uk/37306/ https://eprints.nottingham.ac.uk/37306/ https://eprints.nottingham.ac.uk/37306/ |