Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches
Over the past few years, microRNAs (miRNAs) have not only emerged as integral regulators of gene expression at the post-transcriptional level but also respond to signalling molecules to affect cell function(s). miRNAs crosstalk with a variety of the key cellular signalling networks such as Wnt, tran...
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| Format: | Article |
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BioMed Central
2016
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| Online Access: | https://eprints.nottingham.ac.uk/37143/ |
| _version_ | 1848795400391098368 |
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| author | Onyido, Emenike K. Sweeney, Eloise Nateri, Abdolrahman Shams |
| author_facet | Onyido, Emenike K. Sweeney, Eloise Nateri, Abdolrahman Shams |
| author_sort | Onyido, Emenike K. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Over the past few years, microRNAs (miRNAs) have not only emerged as integral regulators of gene expression at the post-transcriptional level but also respond to signalling molecules to affect cell function(s). miRNAs crosstalk with a variety of the key cellular signalling networks such as Wnt, transforming growth factor-β and Notch, control stem cell activity in maintaining tissue homeostasis, while if dysregulated contributes to the initiation and progression of cancer. Herein, we overview the molecular mechanism(s) underlying the crosstalk between Wntsignalling components (canonical and non-canonical) and miRNAs, as well as changes in the miRNA/Wnt-signalling components observed in the different forms of cancer. Furthermore, the fundamental understanding of miRNAmediated regulation of Wnt-signalling pathway and vice versa has been significantly improved by high-throughput genomics and bioinformatics technologies. Whilst, these approaches have identified a number of specific miRNA(s) that function as oncogenes or tumour suppressors, additional analyses will be necessary to fully unravel the links among conserved cellular signalling pathways and miRNAs and their potential associated components in cancer, thereby creating therapeutic avenues against tumours. Hence, we also discuss the current challenges associated with Wnt-signalling/miRNAs complex and the analysis using the biomedical experimental and bioinformatics approaches. |
| first_indexed | 2025-11-14T19:31:29Z |
| format | Article |
| id | nottingham-37143 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:31:29Z |
| publishDate | 2016 |
| publisher | BioMed Central |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-371432020-05-04T18:13:54Z https://eprints.nottingham.ac.uk/37143/ Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches Onyido, Emenike K. Sweeney, Eloise Nateri, Abdolrahman Shams Over the past few years, microRNAs (miRNAs) have not only emerged as integral regulators of gene expression at the post-transcriptional level but also respond to signalling molecules to affect cell function(s). miRNAs crosstalk with a variety of the key cellular signalling networks such as Wnt, transforming growth factor-β and Notch, control stem cell activity in maintaining tissue homeostasis, while if dysregulated contributes to the initiation and progression of cancer. Herein, we overview the molecular mechanism(s) underlying the crosstalk between Wntsignalling components (canonical and non-canonical) and miRNAs, as well as changes in the miRNA/Wnt-signalling components observed in the different forms of cancer. Furthermore, the fundamental understanding of miRNAmediated regulation of Wnt-signalling pathway and vice versa has been significantly improved by high-throughput genomics and bioinformatics technologies. Whilst, these approaches have identified a number of specific miRNA(s) that function as oncogenes or tumour suppressors, additional analyses will be necessary to fully unravel the links among conserved cellular signalling pathways and miRNAs and their potential associated components in cancer, thereby creating therapeutic avenues against tumours. Hence, we also discuss the current challenges associated with Wnt-signalling/miRNAs complex and the analysis using the biomedical experimental and bioinformatics approaches. BioMed Central 2016-09-02 Article PeerReviewed Onyido, Emenike K., Sweeney, Eloise and Nateri, Abdolrahman Shams (2016) Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches. Molecular Cancer, 15 (56). ISSN 1476-4598 Cancer; cancer stem cell; miRNA; Wnt-signalling; next generation sequencing; sRNA-Seq and ChIP-Seq http://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-016-0541-3 doi:10.1186/s12943-016-0541-3 doi:10.1186/s12943-016-0541-3 |
| spellingShingle | Cancer; cancer stem cell; miRNA; Wnt-signalling; next generation sequencing; sRNA-Seq and ChIP-Seq Onyido, Emenike K. Sweeney, Eloise Nateri, Abdolrahman Shams Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches |
| title | Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches |
| title_full | Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches |
| title_fullStr | Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches |
| title_full_unstemmed | Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches |
| title_short | Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches |
| title_sort | wnt-signalling pathways and micrornas network in carcinogenesis: experimental and bioinformatics approaches |
| topic | Cancer; cancer stem cell; miRNA; Wnt-signalling; next generation sequencing; sRNA-Seq and ChIP-Seq |
| url | https://eprints.nottingham.ac.uk/37143/ https://eprints.nottingham.ac.uk/37143/ https://eprints.nottingham.ac.uk/37143/ |