Multiple circulating cytokines are coelevated in chronic obstructive pulmonary disease
Inflammatory biomarkers, including cytokines, are associated with COPD, but the association of particular circulating cytokines with systemic pathology remains equivocal. To investigate this, we developed a protein microarray system to detect multiple cytokines in small volumes of serum. Fourteen cy...
| Main Authors: | , , , , , , |
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| Format: | Article |
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Hindawi
2016
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| Online Access: | https://eprints.nottingham.ac.uk/37080/ |
| _version_ | 1848795387770437632 |
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| author | Selvarajah, Senthooran Todd, Ian Tighe, Patrick J. John, Michelle Bolton, Charlotte E. Harrison, Timothy W. Fairclough, Lucy C. |
| author_facet | Selvarajah, Senthooran Todd, Ian Tighe, Patrick J. John, Michelle Bolton, Charlotte E. Harrison, Timothy W. Fairclough, Lucy C. |
| author_sort | Selvarajah, Senthooran |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Inflammatory biomarkers, including cytokines, are associated with COPD, but the association of particular circulating cytokines with systemic pathology remains equivocal. To investigate this, we developed a protein microarray system to detect multiple cytokines in small volumes of serum. Fourteen cytokines were measured in serum from never-smokers, ex-smokers, current smokers, and COPD patients (GOLD stages 1–3). Certain individual circulating cytokines (particularly TNFa and IL-1b) were significantly elevated in concentration in the serum of particular COPD patients (and some current/ex-smokers without COPD) and may serve as markers of particularly significant systemic inflammation. However, numerous circulating cytokines were raised such that their combined, but not individual, elevation was significantly associated with severity of disease, and these may be further indicators of, and contributors to, the systemic inflammatory manifestations of COPD. The coelevation of numerous circulating cytokines in COPD is consistent with the insidious development, chronic nature, and systemic comorbidities of the disease. |
| first_indexed | 2025-11-14T19:31:17Z |
| format | Article |
| id | nottingham-37080 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:31:17Z |
| publishDate | 2016 |
| publisher | Hindawi |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-370802020-05-04T17:59:52Z https://eprints.nottingham.ac.uk/37080/ Multiple circulating cytokines are coelevated in chronic obstructive pulmonary disease Selvarajah, Senthooran Todd, Ian Tighe, Patrick J. John, Michelle Bolton, Charlotte E. Harrison, Timothy W. Fairclough, Lucy C. Inflammatory biomarkers, including cytokines, are associated with COPD, but the association of particular circulating cytokines with systemic pathology remains equivocal. To investigate this, we developed a protein microarray system to detect multiple cytokines in small volumes of serum. Fourteen cytokines were measured in serum from never-smokers, ex-smokers, current smokers, and COPD patients (GOLD stages 1–3). Certain individual circulating cytokines (particularly TNFa and IL-1b) were significantly elevated in concentration in the serum of particular COPD patients (and some current/ex-smokers without COPD) and may serve as markers of particularly significant systemic inflammation. However, numerous circulating cytokines were raised such that their combined, but not individual, elevation was significantly associated with severity of disease, and these may be further indicators of, and contributors to, the systemic inflammatory manifestations of COPD. The coelevation of numerous circulating cytokines in COPD is consistent with the insidious development, chronic nature, and systemic comorbidities of the disease. Hindawi 2016-07-25 Article PeerReviewed Selvarajah, Senthooran, Todd, Ian, Tighe, Patrick J., John, Michelle, Bolton, Charlotte E., Harrison, Timothy W. and Fairclough, Lucy C. (2016) Multiple circulating cytokines are coelevated in chronic obstructive pulmonary disease. Mediators of Inflammation, 2016 . p. 3604842. ISSN 1466-1861 https://www.hindawi.com/journals/mi/2016/3604842/ doi:10.1155/2016/3604842 doi:10.1155/2016/3604842 |
| spellingShingle | Selvarajah, Senthooran Todd, Ian Tighe, Patrick J. John, Michelle Bolton, Charlotte E. Harrison, Timothy W. Fairclough, Lucy C. Multiple circulating cytokines are coelevated in chronic obstructive pulmonary disease |
| title | Multiple circulating cytokines are coelevated in chronic obstructive pulmonary disease |
| title_full | Multiple circulating cytokines are coelevated in chronic obstructive pulmonary disease |
| title_fullStr | Multiple circulating cytokines are coelevated in chronic obstructive pulmonary disease |
| title_full_unstemmed | Multiple circulating cytokines are coelevated in chronic obstructive pulmonary disease |
| title_short | Multiple circulating cytokines are coelevated in chronic obstructive pulmonary disease |
| title_sort | multiple circulating cytokines are coelevated in chronic obstructive pulmonary disease |
| url | https://eprints.nottingham.ac.uk/37080/ https://eprints.nottingham.ac.uk/37080/ https://eprints.nottingham.ac.uk/37080/ |