Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex
Sex differences in learned fear expression and extinction involve the medial prefrontal cortex (mPFC). We recently demonstrated that enhanced learned fear expression during auditory fear extinction and its recall is linked to persistent theta activation in the prelimbic (PL) but not infralimbic (IL)...
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| Format: | Article |
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Elsevier
2016
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| Online Access: | https://eprints.nottingham.ac.uk/37029/ |
| _version_ | 1848795377804771328 |
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| author | Fenton, G.E. Halliday, D.M. Mason, Rob Bredy, Timothy W. Stevenson, Carl W. |
| author_facet | Fenton, G.E. Halliday, D.M. Mason, Rob Bredy, Timothy W. Stevenson, Carl W. |
| author_sort | Fenton, G.E. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Sex differences in learned fear expression and extinction involve the medial prefrontal cortex (mPFC). We recently demonstrated that enhanced learned fear expression during auditory fear extinction and its recall is linked to persistent theta activation in the prelimbic (PL) but not infralimbic (IL) cortex of female rats. Emerging evidence indicates that gamma oscillations in mPFC are also implicated in the expression and extinction of learned fear. Therefore we re-examined our in vivo electrophysiology data and found that females showed persistent PL gamma activation during extinction and a failure of IL gamma activation during extinction recall. Altered prefrontal gamma oscillations thus accompany sex differences in learned fear expression and its extinction. These findings are relevant for understanding the neural basis of post-traumatic stress disorder, which is more prevalent in women and involves impaired extinction and mPFC dysfunction. |
| first_indexed | 2025-11-14T19:31:08Z |
| format | Article |
| id | nottingham-37029 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:31:08Z |
| publishDate | 2016 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-370292020-05-04T20:00:02Z https://eprints.nottingham.ac.uk/37029/ Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex Fenton, G.E. Halliday, D.M. Mason, Rob Bredy, Timothy W. Stevenson, Carl W. Sex differences in learned fear expression and extinction involve the medial prefrontal cortex (mPFC). We recently demonstrated that enhanced learned fear expression during auditory fear extinction and its recall is linked to persistent theta activation in the prelimbic (PL) but not infralimbic (IL) cortex of female rats. Emerging evidence indicates that gamma oscillations in mPFC are also implicated in the expression and extinction of learned fear. Therefore we re-examined our in vivo electrophysiology data and found that females showed persistent PL gamma activation during extinction and a failure of IL gamma activation during extinction recall. Altered prefrontal gamma oscillations thus accompany sex differences in learned fear expression and its extinction. These findings are relevant for understanding the neural basis of post-traumatic stress disorder, which is more prevalent in women and involves impaired extinction and mPFC dysfunction. Elsevier 2016-11 Article PeerReviewed Fenton, G.E., Halliday, D.M., Mason, Rob, Bredy, Timothy W. and Stevenson, Carl W. (2016) Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex. Neurobiology of Learning and Memory, 135 . pp. 66-72. ISSN 1095-9564 Sex differences; Fear conditioning; Extinction; Prelimbic; Infralimbic; Gamma oscillations http://www.sciencedirect.com/science/article/pii/S1074742716300934 doi: 10.1016/j.nlm.2016.06.019 doi: 10.1016/j.nlm.2016.06.019 |
| spellingShingle | Sex differences; Fear conditioning; Extinction; Prelimbic; Infralimbic; Gamma oscillations Fenton, G.E. Halliday, D.M. Mason, Rob Bredy, Timothy W. Stevenson, Carl W. Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex |
| title | Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex |
| title_full | Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex |
| title_fullStr | Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex |
| title_full_unstemmed | Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex |
| title_short | Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex |
| title_sort | sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex |
| topic | Sex differences; Fear conditioning; Extinction; Prelimbic; Infralimbic; Gamma oscillations |
| url | https://eprints.nottingham.ac.uk/37029/ https://eprints.nottingham.ac.uk/37029/ https://eprints.nottingham.ac.uk/37029/ |