Characterisation of human saliva as a platform for oral dissolution medium development
Human saliva is a biological fluid of great importance in the field of dissolution testing. However, until now, no consensus has been reached on its key characteristics relevant to dissolution testing. As a result, it is difficult to select or develop an in vitro dissolution medium to best represent...
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| Format: | Article |
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Elsevier
2016
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| Online Access: | https://eprints.nottingham.ac.uk/36096/ |
| _version_ | 1848795222511714304 |
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| author | Gittings, Sally Turnbull, Neil Henry, Brian Roberts, Clive J. Gershkovich, Pavel |
| author_facet | Gittings, Sally Turnbull, Neil Henry, Brian Roberts, Clive J. Gershkovich, Pavel |
| author_sort | Gittings, Sally |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Human saliva is a biological fluid of great importance in the field of dissolution testing. However, until now, no consensus has been reached on its key characteristics relevant to dissolution testing. As a result, it is difficult to select or develop an in vitro dissolution medium to best represent human saliva. In this study, the pH, buffer capacity, surface tension, viscosity and flow rate of both unstimulated (US) and stimulated (SS) human saliva were investigated in order to provide a platform of reference for future dissolution studies using simulated salivary fluids. Age and gender related differences in a sample size of 30 participants for each parameter were investigated. Significant differences were established between US and SS for all characteristics except surface tension. Therefore, the requirement for using two simulated salivary fluids should be considered when developing an oral dissolution model. |
| first_indexed | 2025-11-14T19:28:39Z |
| format | Article |
| id | nottingham-36096 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:28:39Z |
| publishDate | 2016 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-360962020-05-04T17:38:45Z https://eprints.nottingham.ac.uk/36096/ Characterisation of human saliva as a platform for oral dissolution medium development Gittings, Sally Turnbull, Neil Henry, Brian Roberts, Clive J. Gershkovich, Pavel Human saliva is a biological fluid of great importance in the field of dissolution testing. However, until now, no consensus has been reached on its key characteristics relevant to dissolution testing. As a result, it is difficult to select or develop an in vitro dissolution medium to best represent human saliva. In this study, the pH, buffer capacity, surface tension, viscosity and flow rate of both unstimulated (US) and stimulated (SS) human saliva were investigated in order to provide a platform of reference for future dissolution studies using simulated salivary fluids. Age and gender related differences in a sample size of 30 participants for each parameter were investigated. Significant differences were established between US and SS for all characteristics except surface tension. Therefore, the requirement for using two simulated salivary fluids should be considered when developing an oral dissolution model. Elsevier 2016-04-01 Article PeerReviewed Gittings, Sally, Turnbull, Neil, Henry, Brian, Roberts, Clive J. and Gershkovich, Pavel (2016) Characterisation of human saliva as a platform for oral dissolution medium development. European Journal of Pharmaceutics and Biopharmaceutics, 91 . pp. 16-24. ISSN 0939-6411 Human saliva; Taste masking; Dissolution; Biorelevant medium; Physicochemical characteristics; Oral cavity http://www.sciencedirect.com/science/article/pii/S0939641115000107 doi:10.1016/j.ejpb.2015.01.007 doi:10.1016/j.ejpb.2015.01.007 |
| spellingShingle | Human saliva; Taste masking; Dissolution; Biorelevant medium; Physicochemical characteristics; Oral cavity Gittings, Sally Turnbull, Neil Henry, Brian Roberts, Clive J. Gershkovich, Pavel Characterisation of human saliva as a platform for oral dissolution medium development |
| title | Characterisation of human saliva as a platform for oral dissolution medium development |
| title_full | Characterisation of human saliva as a platform for oral dissolution medium development |
| title_fullStr | Characterisation of human saliva as a platform for oral dissolution medium development |
| title_full_unstemmed | Characterisation of human saliva as a platform for oral dissolution medium development |
| title_short | Characterisation of human saliva as a platform for oral dissolution medium development |
| title_sort | characterisation of human saliva as a platform for oral dissolution medium development |
| topic | Human saliva; Taste masking; Dissolution; Biorelevant medium; Physicochemical characteristics; Oral cavity |
| url | https://eprints.nottingham.ac.uk/36096/ https://eprints.nottingham.ac.uk/36096/ https://eprints.nottingham.ac.uk/36096/ |