ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling

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ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling

The transcription factor Nrf2 and its repressor protein Keap1 play key roles in the regulation of antioxidant stress responses and both Keap1-Nrf2 signalling and oxidative stress have been implicated in the pathogenesis of the ALS-FTLD spectrum of neurodegenerative disorders. The Keap1-binding partn...

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Bibliographic Details
Main Authors:	Goode, Alice, Rea, Sarah, Sultana, Melanie, Shaw, Barry, Searle, Mark S., Layfield, Robert
Format:	Article
Published:	Elsevier 2016
Subjects:	ALS-FTLD; SQSTM1/p62; Keap1-Nrf2; Oxidative stress
Online Access:	https://eprints.nottingham.ac.uk/36058/

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