Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09‐related pneumonia: an individual participant data meta‐analysis
BACKGROUND: The impact of neuraminidase inhibitors (NAIs) on influenza‐related pneumonia (IRP) is not established. Our objective was to investigate the association between NAI treatment and IRP incidence and outcomes in patients hospitalised with A(H1N1)pdm09 virus infection. METHODS: A worldwide...
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| Format: | Article |
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John Wiley and Sons Inc.
2016
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| Online Access: | https://eprints.nottingham.ac.uk/36034/ |
| _version_ | 1848795209332162560 |
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| author | Muthuri, Stella G. Venkatesan, Sudhir Myles, Puja R. Leonardi-Bee, Jo Lim, Wei Shen Al Mamun, Abdullah Anovadiya, Ashish P Araújo, Wildo N Azziz‐Baumgartner, Eduardo Báez, Clarisa Bantar, Carlos Barhoush, Mazen M Bassetti, Matteo Beovic, Bojana Bingisser, Roland Bonmarin, Isabelle Borja‐Aburto, Victor H. Cao, Bin Carratala, Jordi Cuezzo, María R. Denholm, Justin T Dominguez, Samuel R. Duarte, Pericles A. D. Dubnov‐Raz, Gal Echavarria,, Marcela Fanella, Sergio Fraser, James Gao, Zhancheng Gérardin, Patrick Giannella, Maddalena Gubbels, Sophie Herberg, Jethro Higuera Iglesias, Anjarath L Hoeger, Peter H Hoffmann, Matthias Hu, Xiaoyun Islam, Quazi T Jiménez, Mirela F. Kandeel, Amr Keijzers, Gerben Khalili,, Hossein Khandaker, Gulam Knight, Marian Kusznierz, Gabriela Kuzman, Ilija Kwan, Arthur M. C. Lahlou Amine, Idriss Langenegger, Eduard Lankarani, Kamran B. Leo, Yee‐Sin Linko, Rita Liu, Pei Madanat, Faris Manabe, Toshie Mayo‐Montero, Elga McGeer, Allison Memish, Ziad A. Metan, Gokhan Mikić, Dragan Mohn, Kristin G. I. Moradi, Ahmadreza Nymadawa, Pagbajabyn Ozbay, Bulent Ozkan, Mehpare Parekh, Dhruv Paul, Mical Poeppl, Wolfgang Polack, Fernando P Rath, Barbara A. Rodríguez, Alejandro H. Siqueira, Marilda M. Skręt‐Magierło, Joanna Talarek, Ewa Tang, Julian W. Torres, Antoni Törün, Selda H. Tran, Dat Uyeki, Timothy M. van Zwol, Annelies Vaudry, Wendy Velyvyte, Daiva Vidmar, Tjasa Zarogoulidis, Paul Nguyen-Van-Tam, Jonathan S. |
| author_facet | Muthuri, Stella G. Venkatesan, Sudhir Myles, Puja R. Leonardi-Bee, Jo Lim, Wei Shen Al Mamun, Abdullah Anovadiya, Ashish P Araújo, Wildo N Azziz‐Baumgartner, Eduardo Báez, Clarisa Bantar, Carlos Barhoush, Mazen M Bassetti, Matteo Beovic, Bojana Bingisser, Roland Bonmarin, Isabelle Borja‐Aburto, Victor H. Cao, Bin Carratala, Jordi Cuezzo, María R. Denholm, Justin T Dominguez, Samuel R. Duarte, Pericles A. D. Dubnov‐Raz, Gal Echavarria,, Marcela Fanella, Sergio Fraser, James Gao, Zhancheng Gérardin, Patrick Giannella, Maddalena Gubbels, Sophie Herberg, Jethro Higuera Iglesias, Anjarath L Hoeger, Peter H Hoffmann, Matthias Hu, Xiaoyun Islam, Quazi T Jiménez, Mirela F. Kandeel, Amr Keijzers, Gerben Khalili,, Hossein Khandaker, Gulam Knight, Marian Kusznierz, Gabriela Kuzman, Ilija Kwan, Arthur M. C. Lahlou Amine, Idriss Langenegger, Eduard Lankarani, Kamran B. Leo, Yee‐Sin Linko, Rita Liu, Pei Madanat, Faris Manabe, Toshie Mayo‐Montero, Elga McGeer, Allison Memish, Ziad A. Metan, Gokhan Mikić, Dragan Mohn, Kristin G. I. Moradi, Ahmadreza Nymadawa, Pagbajabyn Ozbay, Bulent Ozkan, Mehpare Parekh, Dhruv Paul, Mical Poeppl, Wolfgang Polack, Fernando P Rath, Barbara A. Rodríguez, Alejandro H. Siqueira, Marilda M. Skręt‐Magierło, Joanna Talarek, Ewa Tang, Julian W. Torres, Antoni Törün, Selda H. Tran, Dat Uyeki, Timothy M. van Zwol, Annelies Vaudry, Wendy Velyvyte, Daiva Vidmar, Tjasa Zarogoulidis, Paul Nguyen-Van-Tam, Jonathan S. |
| author_sort | Muthuri, Stella G. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | BACKGROUND: The impact of neuraminidase inhibitors (NAIs) on influenza‐related pneumonia (IRP) is not established. Our objective was to investigate the association between NAI treatment and IRP incidence and outcomes in patients hospitalised with A(H1N1)pdm09 virus infection.
METHODS: A worldwide meta‐analysis of individual participant data from 20 634 hospitalised patients with laboratory‐confirmed A(H1N1)pdm09 (n = 20 021) or clinically diagnosed (n = 613) ‘pandemic influenza’. The primary outcome was radiologically confirmed IRP. Odds ratios (OR) were estimated using generalised linear mixed modelling, adjusting for NAI treatment propensity, antibiotics and corticosteroids.
RESULTS: Of 20 634 included participants, 5978 (29·0%) had IRP; conversely, 3349 (16·2%) had confirmed the absence of radiographic pneumonia (the comparator). Early NAI treatment (within 2 days of symptom onset) versus no NAI was not significantly associated with IRP [adj. OR 0·83 (95% CI 0·64–1·06; P = 0·136)]. Among the 5978 patients with IRP, early NAI treatment versus none did not impact on mortality [adj. OR = 0·72 (0·44–1·17; P = 0·180)] or likelihood of requiring ventilatory support [adj. OR = 1·17 (0·71–1·92; P = 0·537)], but early treatment versus later significantly reduced mortality [adj. OR = 0·70 (0·55–0·88; P = 0·003)] and likelihood of requiring ventilatory support [adj. OR = 0·68 (0·54–0·85; P = 0·001)].
CONCLUSIONS: Early NAI treatment of patients hospitalised with A(H1N1)pdm09 virus infection versus no treatment did not reduce the likelihood of IRP. However, in patients who developed IRP, early NAI treatment versus later reduced the likelihood of mortality and needing ventilatory support. |
| first_indexed | 2025-11-14T19:28:27Z |
| format | Article |
| id | nottingham-36034 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:28:27Z |
| publishDate | 2016 |
| publisher | John Wiley and Sons Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-360342020-05-04T17:43:51Z https://eprints.nottingham.ac.uk/36034/ Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09‐related pneumonia: an individual participant data meta‐analysis Muthuri, Stella G. Venkatesan, Sudhir Myles, Puja R. Leonardi-Bee, Jo Lim, Wei Shen Al Mamun, Abdullah Anovadiya, Ashish P Araújo, Wildo N Azziz‐Baumgartner, Eduardo Báez, Clarisa Bantar, Carlos Barhoush, Mazen M Bassetti, Matteo Beovic, Bojana Bingisser, Roland Bonmarin, Isabelle Borja‐Aburto, Victor H. Cao, Bin Carratala, Jordi Cuezzo, María R. Denholm, Justin T Dominguez, Samuel R. Duarte, Pericles A. D. Dubnov‐Raz, Gal Echavarria,, Marcela Fanella, Sergio Fraser, James Gao, Zhancheng Gérardin, Patrick Giannella, Maddalena Gubbels, Sophie Herberg, Jethro Higuera Iglesias, Anjarath L Hoeger, Peter H Hoffmann, Matthias Hu, Xiaoyun Islam, Quazi T Jiménez, Mirela F. Kandeel, Amr Keijzers, Gerben Khalili,, Hossein Khandaker, Gulam Knight, Marian Kusznierz, Gabriela Kuzman, Ilija Kwan, Arthur M. C. Lahlou Amine, Idriss Langenegger, Eduard Lankarani, Kamran B. Leo, Yee‐Sin Linko, Rita Liu, Pei Madanat, Faris Manabe, Toshie Mayo‐Montero, Elga McGeer, Allison Memish, Ziad A. Metan, Gokhan Mikić, Dragan Mohn, Kristin G. I. Moradi, Ahmadreza Nymadawa, Pagbajabyn Ozbay, Bulent Ozkan, Mehpare Parekh, Dhruv Paul, Mical Poeppl, Wolfgang Polack, Fernando P Rath, Barbara A. Rodríguez, Alejandro H. Siqueira, Marilda M. Skręt‐Magierło, Joanna Talarek, Ewa Tang, Julian W. Torres, Antoni Törün, Selda H. Tran, Dat Uyeki, Timothy M. van Zwol, Annelies Vaudry, Wendy Velyvyte, Daiva Vidmar, Tjasa Zarogoulidis, Paul Nguyen-Van-Tam, Jonathan S. BACKGROUND: The impact of neuraminidase inhibitors (NAIs) on influenza‐related pneumonia (IRP) is not established. Our objective was to investigate the association between NAI treatment and IRP incidence and outcomes in patients hospitalised with A(H1N1)pdm09 virus infection. METHODS: A worldwide meta‐analysis of individual participant data from 20 634 hospitalised patients with laboratory‐confirmed A(H1N1)pdm09 (n = 20 021) or clinically diagnosed (n = 613) ‘pandemic influenza’. The primary outcome was radiologically confirmed IRP. Odds ratios (OR) were estimated using generalised linear mixed modelling, adjusting for NAI treatment propensity, antibiotics and corticosteroids. RESULTS: Of 20 634 included participants, 5978 (29·0%) had IRP; conversely, 3349 (16·2%) had confirmed the absence of radiographic pneumonia (the comparator). Early NAI treatment (within 2 days of symptom onset) versus no NAI was not significantly associated with IRP [adj. OR 0·83 (95% CI 0·64–1·06; P = 0·136)]. Among the 5978 patients with IRP, early NAI treatment versus none did not impact on mortality [adj. OR = 0·72 (0·44–1·17; P = 0·180)] or likelihood of requiring ventilatory support [adj. OR = 1·17 (0·71–1·92; P = 0·537)], but early treatment versus later significantly reduced mortality [adj. OR = 0·70 (0·55–0·88; P = 0·003)] and likelihood of requiring ventilatory support [adj. OR = 0·68 (0·54–0·85; P = 0·001)]. CONCLUSIONS: Early NAI treatment of patients hospitalised with A(H1N1)pdm09 virus infection versus no treatment did not reduce the likelihood of IRP. However, in patients who developed IRP, early NAI treatment versus later reduced the likelihood of mortality and needing ventilatory support. John Wiley and Sons Inc. 2016-05-01 Article PeerReviewed Muthuri, Stella G., Venkatesan, Sudhir, Myles, Puja R., Leonardi-Bee, Jo, Lim, Wei Shen, Al Mamun, Abdullah, Anovadiya, Ashish P, Araújo, Wildo N, Azziz‐Baumgartner, Eduardo, Báez, Clarisa, Bantar, Carlos, Barhoush, Mazen M, Bassetti, Matteo, Beovic, Bojana, Bingisser, Roland, Bonmarin, Isabelle, Borja‐Aburto, Victor H., Cao, Bin, Carratala, Jordi, Cuezzo, María R., Denholm, Justin T, Dominguez, Samuel R., Duarte, Pericles A. D., Dubnov‐Raz, Gal, Echavarria,, Marcela, Fanella, Sergio, Fraser, James, Gao, Zhancheng, Gérardin, Patrick, Giannella, Maddalena, Gubbels, Sophie, Herberg, Jethro, Higuera Iglesias, Anjarath L, Hoeger, Peter H, Hoffmann, Matthias, Hu, Xiaoyun, Islam, Quazi T, Jiménez, Mirela F., Kandeel, Amr, Keijzers, Gerben, Khalili,, Hossein, Khandaker, Gulam, Knight, Marian, Kusznierz, Gabriela, Kuzman, Ilija, Kwan, Arthur M. C., Lahlou Amine, Idriss, Langenegger, Eduard, Lankarani, Kamran B., Leo, Yee‐Sin, Linko, Rita, Liu, Pei, Madanat, Faris, Manabe, Toshie, Mayo‐Montero, Elga, McGeer, Allison, Memish, Ziad A., Metan, Gokhan, Mikić, Dragan, Mohn, Kristin G. I., Moradi, Ahmadreza, Nymadawa, Pagbajabyn, Ozbay, Bulent, Ozkan, Mehpare, Parekh, Dhruv, Paul, Mical, Poeppl, Wolfgang, Polack, Fernando P, Rath, Barbara A., Rodríguez, Alejandro H., Siqueira, Marilda M., Skręt‐Magierło, Joanna, Talarek, Ewa, Tang, Julian W., Torres, Antoni, Törün, Selda H., Tran, Dat, Uyeki, Timothy M., van Zwol, Annelies, Vaudry, Wendy, Velyvyte, Daiva, Vidmar, Tjasa, Zarogoulidis, Paul and Nguyen-Van-Tam, Jonathan S. (2016) Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09‐related pneumonia: an individual participant data meta‐analysis. Influenza and Other Respiratory Viruses, 10 (3). pp. 192-204. ISSN 1750-2640 Hospitalisation individual participant data meta-analyses influenza-related pneumonia neuraminidase inhibitors. http://onlinelibrary.wiley.com/doi/10.1111/irv.12363/abstract doi:10.1111/irv.12363 doi:10.1111/irv.12363 |
| spellingShingle | Hospitalisation individual participant data meta-analyses influenza-related pneumonia neuraminidase inhibitors. Muthuri, Stella G. Venkatesan, Sudhir Myles, Puja R. Leonardi-Bee, Jo Lim, Wei Shen Al Mamun, Abdullah Anovadiya, Ashish P Araújo, Wildo N Azziz‐Baumgartner, Eduardo Báez, Clarisa Bantar, Carlos Barhoush, Mazen M Bassetti, Matteo Beovic, Bojana Bingisser, Roland Bonmarin, Isabelle Borja‐Aburto, Victor H. Cao, Bin Carratala, Jordi Cuezzo, María R. Denholm, Justin T Dominguez, Samuel R. Duarte, Pericles A. D. Dubnov‐Raz, Gal Echavarria,, Marcela Fanella, Sergio Fraser, James Gao, Zhancheng Gérardin, Patrick Giannella, Maddalena Gubbels, Sophie Herberg, Jethro Higuera Iglesias, Anjarath L Hoeger, Peter H Hoffmann, Matthias Hu, Xiaoyun Islam, Quazi T Jiménez, Mirela F. Kandeel, Amr Keijzers, Gerben Khalili,, Hossein Khandaker, Gulam Knight, Marian Kusznierz, Gabriela Kuzman, Ilija Kwan, Arthur M. C. Lahlou Amine, Idriss Langenegger, Eduard Lankarani, Kamran B. Leo, Yee‐Sin Linko, Rita Liu, Pei Madanat, Faris Manabe, Toshie Mayo‐Montero, Elga McGeer, Allison Memish, Ziad A. Metan, Gokhan Mikić, Dragan Mohn, Kristin G. I. Moradi, Ahmadreza Nymadawa, Pagbajabyn Ozbay, Bulent Ozkan, Mehpare Parekh, Dhruv Paul, Mical Poeppl, Wolfgang Polack, Fernando P Rath, Barbara A. Rodríguez, Alejandro H. Siqueira, Marilda M. Skręt‐Magierło, Joanna Talarek, Ewa Tang, Julian W. Torres, Antoni Törün, Selda H. Tran, Dat Uyeki, Timothy M. van Zwol, Annelies Vaudry, Wendy Velyvyte, Daiva Vidmar, Tjasa Zarogoulidis, Paul Nguyen-Van-Tam, Jonathan S. Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09‐related pneumonia: an individual participant data meta‐analysis |
| title | Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09‐related pneumonia: an individual participant data meta‐analysis |
| title_full | Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09‐related pneumonia: an individual participant data meta‐analysis |
| title_fullStr | Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09‐related pneumonia: an individual participant data meta‐analysis |
| title_full_unstemmed | Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09‐related pneumonia: an individual participant data meta‐analysis |
| title_short | Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09‐related pneumonia: an individual participant data meta‐analysis |
| title_sort | impact of neuraminidase inhibitors on influenza a(h1n1)pdm09‐related pneumonia: an individual participant data meta‐analysis |
| topic | Hospitalisation individual participant data meta-analyses influenza-related pneumonia neuraminidase inhibitors. |
| url | https://eprints.nottingham.ac.uk/36034/ https://eprints.nottingham.ac.uk/36034/ https://eprints.nottingham.ac.uk/36034/ |