Human skeletal muscle disuse atrophy: effects on muscle protein synthesis, breakdown and insulin resistance- a qualitative review

QR Code

Human skeletal muscle disuse atrophy: effects on muscle protein synthesis, breakdown and insulin resistance- a qualitative review

The ever increasing burden of an ageing population and pandemic of metabolic syndrome worldwide demands further understanding of the modifiable risk factors in reducing disability and morbidity associated with these conditions. Disuse skeletal muscle atrophy (sometimes referred to as “simple” atroph...

Full description

Bibliographic Details
Main Authors:	Rudrappa, Supreeth S., Wilkinson, Daniel, Greenhaff, Paul L., Smith, Kenneth, Idris, Iskandar, Atherton, Philip J.
Format:	Article
Published:	Frontiers Research Foundation 2016
Subjects:	skeletal muscle; disuse; immobilization; protein metabolism; diabetes
Online Access:	https://eprints.nottingham.ac.uk/35937/

Similar Items

Insulin resistance in health and disease: exploring the role of disuse skeletal muscle atrophy, testosterone and Beta-Hydroxy-Beta-Methylbutyrate (HMB) in young and older men
by: Shanthaveerappa Rudrappa, Supreeth
Published: (2021)

Exploring mechanisms of disuse atrophy and optimal rehabilitation strategies for the restoration of muscle mass, structure & function
by: Inns, Thomas Benjamin
Published: (2023)

Acute disuse muscle atrophy in health and disease: an investigation of the timecourse, functional effects and a potential treatment strategy
by: Hardy, Edward John Oliver
Published: (2023)

A novel puromycin decorporation method to quantify skeletal muscle protein breakdown: a proof-of-concept study
by: Crossland, Hannah, et al.
Published: (2017)

The heterogeneity of the functional, metabolic, and molecular responses of skeletal muscle and clinical adaptations to exercise training in pre-clinical and human models
by: Farrash, Wesam
Published: (2020)

The effect of vitamin D on the development and function of skeletal muscle
by: Alliband, Kathryn
Published: (2024)

Human muscle weakness and fatigue: the effects of disuse, age and exercise
by: White, Michael J.
Published: (1987)

The metabolic and molecular mechanisms of hyperammonaemia and hyperethanolaemia induced protein catabolism in skeletal muscle cells
by: Crossland, Hannah, et al.
Published: (2018)

Development and application of minimally invasive stable isotope tracers’ measures of muscle mass and muscle protein synthesis/breakdown: insights into ageing skeletal muscle
by: Cegielski, Jessica
Published: (2020)

Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism
by: Wilkinson, Daniel J., et al.
Published: (2017)

The roles of muscle contraction and pharmaceuticals on restoring glucose uptake in a mouse skeletal muscle model of immobilization
by: Kirkpatrick, Euan
Published: (2024)

The role of the pyruvate dehydrogenase complex in the regulation of human skeletal muscle fuel metabolism
by: Laithwaite, David
Published: (2009)

The age-related loss of skeletal muscle mass and function: measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans
by: Wilkinson, Daniel J., et al.
Published: (2018)

Investigation of molecular mechanisms regulating palmitate-induced metabolic inflexibility in a cell-based skeletal muscle model: physiological and pharmacological interventions.
by: Chien, Hung-Che
Published: (2020)

Pharmacological enhancement of leg and muscle microvascular blood flow does not augment anabolic responses in skeletal muscle of young men under fed conditions
by: Phillips, Bethan E., et al.
Published: (2014)

Pain behaviour, locomotor activity, inflammation and muscle metabolic dysregulation in pre-clinical animal models of OA and RA and the impact of PPARɣ agonism intervention
by: Casanova, Nuria
Published: (2019)

The role of skeletal muscle in the initiation and progression of knee osteoarthritis
by: Tonge, Daniel Paul
Published: (2010)

Metabolic and functional characterisation of adult skeletal muscle in down syndrome mouse model (Ts1CJe) for insights into hypotonia in human condition
by: Lim, Chai Ling
Published: (2017)

Differential nitric oxide levels in the blood and skeletal muscle of Type 2 diabetic subjects may be consequence of adiposity: a preliminary study.
by: Krause, M., et al.
Published: (2012)

The impact of delivery profile of essential amino acids upon skeletal muscle protein synthesis in older men: clinical efficacy of pulse vs. bolus supply
by: Mitchell, W. Kyle, et al.
Published: (2015)

Muscle architectural and physiological responses to immobilisation: impact of age and obesity
by: Ali, Arfan M.
Published: (2020)

The role of the vitamin D receptor in skeletal muscle protein metabolism
by: Bass, Joseph
Published: (2017)

Early structural remodeling and deuterium oxide-derived protein metabolic responses to eccentric and concentric loading in human skeletal muscle
by: Franchi, Martino V., et al.
Published: (2015)

Supplementing essential amino acids with the nitric oxide precursor, l-arginine, enhances skeletal muscle perfusion without impacting anabolism in older men
by: Mitchell, W. Kyle, et al.
Published: (2017)

Amino acid modulation of gut hormone release and defining roles of GLP-1 and insulin in muscle microcirculation and metabolism in older age
by: Abdulla, Haitham M.A.
Published: (2018)

The impact of leucine-enriched whey protein on skeletal muscle anabolism
by: Ely, Isabel
Published: (2024)

The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end points
by: Crossland, Hannah, et al.
Published: (2018)

Effects of ageing and vitamin D deficiency on vitamin D receptor (VDR) expression in human skeletal muscle
by: Ong, Terence
Published: (2015)

Molecular analyses provide insight into mechanisms underlying sarcopenia and myofibre denervation in old skeletal muscles of mice
by: Barns, M., et al.
Published: (2014)

The effects of age upon the expression of three miRNAs in muscle stem cells isolated from two different porcine skeletal muscles
by: Redshaw, Zoe, et al.
Published: (2014)

Exploring the effects of ageing, cancer, and exercise on skeletal muscle mitochondrial function
by: Smart, Thomas
Published: (2024)

The role of the vitamin D axis in skeletal muscle physiology: a multi-modal approach
by: Bollen, Shelby
Published: (2024)

The impacts of bed rest and acute trauma on muscle metabolic health in humans
by: Shur, Natalie F.
Published: (2024)

A dose- rather than delivery profile-dependent mechanism regulates the "muscle-full" effect in response to oral essential amino acid intake in young men
by: Mitchell, William Kyle, et al.
Published: (2015)

Obesity appears to be associated with altered muscle protein synthetic and breakdown responses to increased nutrient delivery in older men, but not reduced muscle mass or contractile function.
by: Murton, Andrew J., et al.
Published: (2015)

Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth
by: Brown, D.M., et al.
Published: (2016)

Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation
by: Stephens, Francis B., et al.
Published: (2014)

Acute cocoa flavanol supplementation improves muscle macro- and microvascular but not anabolic responses to amino acids in older men
by: Phillips, Bethan E., et al.
Published: (2016)

The role of bioactive lipids and lipid binding proteins in skeletal muscle
by: Mohd Noor, Mohd Fadly
Published: (2019)

Mouse mitochondrial lipid composition is defined by age in brain and muscle
by: Pollard, Amelia K., et al.
Published: (2017)