Risk factors for cardiovascular disease in people with idiopathic pulmonary fibrosis: a population-based study
OBJECTIVE: People with idiopathic pulmonary fibrosis (IPF) have been shown to be at an increased risk for cardiovascular (CV) disease, but reasons for this are unknown. The aim of this study was to compare the prevalence of common CV risk factors in people with IPF and the general population and est...
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| Format: | Article |
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Elsevier
2015
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| Online Access: | https://eprints.nottingham.ac.uk/35771/ |
| _version_ | 1848795158048407552 |
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| author | Dallywater, William Powell, Helen A. Hubbard, Richard B. Navaratnam, Vidya |
| author_facet | Dallywater, William Powell, Helen A. Hubbard, Richard B. Navaratnam, Vidya |
| author_sort | Dallywater, William |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | OBJECTIVE: People with idiopathic pulmonary fibrosis (IPF) have been shown to be at an increased risk for cardiovascular (CV) disease, but reasons for this are unknown. The aim of this study was to compare the prevalence of common CV risk factors in people with IPF and the general population and establish the incidence of ischemic heart disease (IHD) and stroke after the diagnosis of IPF, controlling for these risk factors.
METHODS: We used data from a large, UK primary care database to identify incident cases of IPF and matched general-population control subjects. We compared the prevalence of risk factors for CV disease and prescription of CV medications in people with IPF (before diagnosis) with control subjects from the general population and assessed the incidence of IHD and stroke in people with IPF (after diagnosis) compared with control subjects.
RESULTS: We identified 3,211 cases of IPF and 12,307 control subjects. Patients with IPF were more likely to have a record of hypertension (OR, 1.31; 95% CI, 1.19-1.44), and diabetes (OR, 1.20; 95% CI, 1.07-1.34) compared with control subjects; they were also more likely to have been prescribed several CV drugs. The rate of first-time IHD events was more than twice as high in patients than control subjects (rate ratio, 2.32; 95% CI, 1.85-2.93; P < .001), but the incidence of stroke was only marginally higher (P = .09). Rate ratios for IHD and stroke were not altered substantially after adjusting for CV risk factors.
CONCLUSIONS: Several CV risk factors were more prevalent in people with IPF; however, this did not account for the increased rate of IHD in this group of patients. |
| first_indexed | 2025-11-14T19:27:38Z |
| format | Article |
| id | nottingham-35771 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:27:38Z |
| publishDate | 2015 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-357712020-05-04T17:26:39Z https://eprints.nottingham.ac.uk/35771/ Risk factors for cardiovascular disease in people with idiopathic pulmonary fibrosis: a population-based study Dallywater, William Powell, Helen A. Hubbard, Richard B. Navaratnam, Vidya OBJECTIVE: People with idiopathic pulmonary fibrosis (IPF) have been shown to be at an increased risk for cardiovascular (CV) disease, but reasons for this are unknown. The aim of this study was to compare the prevalence of common CV risk factors in people with IPF and the general population and establish the incidence of ischemic heart disease (IHD) and stroke after the diagnosis of IPF, controlling for these risk factors. METHODS: We used data from a large, UK primary care database to identify incident cases of IPF and matched general-population control subjects. We compared the prevalence of risk factors for CV disease and prescription of CV medications in people with IPF (before diagnosis) with control subjects from the general population and assessed the incidence of IHD and stroke in people with IPF (after diagnosis) compared with control subjects. RESULTS: We identified 3,211 cases of IPF and 12,307 control subjects. Patients with IPF were more likely to have a record of hypertension (OR, 1.31; 95% CI, 1.19-1.44), and diabetes (OR, 1.20; 95% CI, 1.07-1.34) compared with control subjects; they were also more likely to have been prescribed several CV drugs. The rate of first-time IHD events was more than twice as high in patients than control subjects (rate ratio, 2.32; 95% CI, 1.85-2.93; P < .001), but the incidence of stroke was only marginally higher (P = .09). Rate ratios for IHD and stroke were not altered substantially after adjusting for CV risk factors. CONCLUSIONS: Several CV risk factors were more prevalent in people with IPF; however, this did not account for the increased rate of IHD in this group of patients. Elsevier 2015-12-16 Article PeerReviewed Dallywater, William, Powell, Helen A., Hubbard, Richard B. and Navaratnam, Vidya (2015) Risk factors for cardiovascular disease in people with idiopathic pulmonary fibrosis: a population-based study. Chest, 147 (1). pp. 150-156. ISSN 1931-3543 http://www.sciencedirect.com/science/article/pii/S0012369215302440 doi:10.1378/chest.14-0041 doi:10.1378/chest.14-0041 |
| spellingShingle | Dallywater, William Powell, Helen A. Hubbard, Richard B. Navaratnam, Vidya Risk factors for cardiovascular disease in people with idiopathic pulmonary fibrosis: a population-based study |
| title | Risk factors for cardiovascular disease in people with idiopathic pulmonary fibrosis: a population-based study |
| title_full | Risk factors for cardiovascular disease in people with idiopathic pulmonary fibrosis: a population-based study |
| title_fullStr | Risk factors for cardiovascular disease in people with idiopathic pulmonary fibrosis: a population-based study |
| title_full_unstemmed | Risk factors for cardiovascular disease in people with idiopathic pulmonary fibrosis: a population-based study |
| title_short | Risk factors for cardiovascular disease in people with idiopathic pulmonary fibrosis: a population-based study |
| title_sort | risk factors for cardiovascular disease in people with idiopathic pulmonary fibrosis: a population-based study |
| url | https://eprints.nottingham.ac.uk/35771/ https://eprints.nottingham.ac.uk/35771/ https://eprints.nottingham.ac.uk/35771/ |