PEGylation of paclitaxel for inhaled chemotherapy
Pulmonary delivery offers an attractive route for delivering chemotherapeutics, with the benefits of high drug concentrations locally and low side effects systemically. However, fast clearance of small molecules in the lungs and the pulmonary toxicity are the main obstacles in this field. In this th...
| Main Author: | |
|---|---|
| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2016
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/35723/ |
| _version_ | 1848795147131682816 |
|---|---|
| author | Luo, Tian |
| author_facet | Luo, Tian |
| author_sort | Luo, Tian |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Pulmonary delivery offers an attractive route for delivering chemotherapeutics, with the benefits of high drug concentrations locally and low side effects systemically. However, fast clearance of small molecules in the lungs and the pulmonary toxicity are the main obstacles in this field. In this thesis, we explored the utility of polyethylene glycol-paclitaxel (PEG-PTX) conjugates to achieve sustained drug release in the lungs. Paclitaxel was linked to 6 kDa and 20 kDa PEG and the conjugates showed good stability and cytotoxicity in vitro. PEG-PTX largely increased the maximum tolerated dose of paclitaxel in mice and significantly enhanced its anti-tumor efficacy following intratracheal instillation in a lung carcinoma mouse model. PEG-PTX 20 kDa presented a prolonged residency and a sustained paclitaxel release in the lungs. This study demonstrated that PEGylation offers a potential delivery system for inhaled chemotherapy with improved anti-tumor efficacy and reduced local toxicity. |
| first_indexed | 2025-11-14T19:27:28Z |
| format | Thesis (University of Nottingham only) |
| id | nottingham-35723 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T19:27:28Z |
| publishDate | 2016 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-357232025-02-28T11:50:20Z https://eprints.nottingham.ac.uk/35723/ PEGylation of paclitaxel for inhaled chemotherapy Luo, Tian Pulmonary delivery offers an attractive route for delivering chemotherapeutics, with the benefits of high drug concentrations locally and low side effects systemically. However, fast clearance of small molecules in the lungs and the pulmonary toxicity are the main obstacles in this field. In this thesis, we explored the utility of polyethylene glycol-paclitaxel (PEG-PTX) conjugates to achieve sustained drug release in the lungs. Paclitaxel was linked to 6 kDa and 20 kDa PEG and the conjugates showed good stability and cytotoxicity in vitro. PEG-PTX largely increased the maximum tolerated dose of paclitaxel in mice and significantly enhanced its anti-tumor efficacy following intratracheal instillation in a lung carcinoma mouse model. PEG-PTX 20 kDa presented a prolonged residency and a sustained paclitaxel release in the lungs. This study demonstrated that PEGylation offers a potential delivery system for inhaled chemotherapy with improved anti-tumor efficacy and reduced local toxicity. 2016-12-14 Thesis (University of Nottingham only) NonPeerReviewed application/pdf en arr https://eprints.nottingham.ac.uk/35723/1/PEGylation%20of%20paclitaxel%20for%20inhaled%20chemotherapy-submitted%20to%20Nottingham.pdf Luo, Tian (2016) PEGylation of paclitaxel for inhaled chemotherapy. PhD thesis, University of Nottingham. Lung cancer; polymer-drug conjugate; PEGylation; pulmonary delivery; paclitaxel |
| spellingShingle | Lung cancer; polymer-drug conjugate; PEGylation; pulmonary delivery; paclitaxel Luo, Tian PEGylation of paclitaxel for inhaled chemotherapy |
| title | PEGylation of paclitaxel for inhaled chemotherapy |
| title_full | PEGylation of paclitaxel for inhaled chemotherapy |
| title_fullStr | PEGylation of paclitaxel for inhaled chemotherapy |
| title_full_unstemmed | PEGylation of paclitaxel for inhaled chemotherapy |
| title_short | PEGylation of paclitaxel for inhaled chemotherapy |
| title_sort | pegylation of paclitaxel for inhaled chemotherapy |
| topic | Lung cancer; polymer-drug conjugate; PEGylation; pulmonary delivery; paclitaxel |
| url | https://eprints.nottingham.ac.uk/35723/ |