TLR2 stimulation regulates the balance between regulatory T cell and Th17 function: a novel mechanism of reduced regulatory T cell function in multiple sclerosis

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TLR2 stimulation regulates the balance between regulatory T cell and Th17 function: a novel mechanism of reduced regulatory T cell function in multiple sclerosis

CD4+CD25hi FOXP3+ regulatory T cells (Tregs) maintain tolerance to self-Ags. Their defective function is involved in the pathogenesis of multiple sclerosis (MS), an inflammatory demyelinating disease of the CNS. However, the mechanisms of such defective function are poorly understood. Recently, we r...

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Bibliographic Details
Main Authors:	Nyirenda, Mukanthu H., Morandi, Elena, Vinkemeier, Uwe, Constantin-Teodosiu, Dumitru, Drinkwater, Sophie, Mee, Maureen, King, Lloyd, Podda, Giulio, Zhang, Guang-Xian, Ghaemmaghami, Amir, Constantinescu, Cris S., Bar-Or, Amit, Gran, Bruno
Format:	Article
Published:	American Association of Immunologists 2015
Online Access:	https://eprints.nottingham.ac.uk/35716/

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