The mannose receptor negatively modulates the Toll-like receptor 4–aryl hydrocarbon receptor–indoleamine 2,3-dioxygenase axis in dendritic cells affecting T helper cell polarization

QR Code

The mannose receptor negatively modulates the Toll-like receptor 4–aryl hydrocarbon receptor–indoleamine 2,3-dioxygenase axis in dendritic cells affecting T helper cell polarization

Background: Dendritic cells (DCs) are key players in the induction and re-elicitation of TH2 responses to allergens. We have previously shown that different C-type lectin receptors on DCs play a major role in allergen recognition and uptake. In particular, mannose receptor (MR), through modulation o...

Full description

Bibliographic Details
Main Authors:	Salazar, Fabián, Hall, Laurence, Negm, Ola H., Awuah, Dennis, Tighe, Patrick J., Shakib, Farouk, Ghaemmaghami, Amir M.
Format:	Article
Published:	Elsevier 2016
Subjects:	Dendritic cells; allergy; TH2; indoleamine 2 3-dioxygenase; C-type lectin receptor; mannose receptor; Toll-like receptor 4; aryl-hydrocarbon receptor; nuclear factor κB
Online Access:	https://eprints.nottingham.ac.uk/35687/

Similar Items

The role of indoleamine 2,3-dioxygenase in modulating allergic responses
by: Salazar, F.
Published: (2016)

Role of lectin receptors in recognition of Pseudomonas aeruginosa biofilms
by: Almuhanna, Yasir Saleh I
Published: (2021)

Identification and characterization of toll-like receptor (TLR) 2 and 4 mutations in colorectal
by: Davoodi, Homa
Published: (2009)

Biological significance of human epidermal growth factor receptor 2 (HER2) in breast cancer: effect of oestrogen receptor
by: Ahmad, Dena Akram Jerjees
Published: (2016)

Effects of NAD at purine receptors in isolated blood vessels
by: Alefishat, Eman, et al.
Published: (2015)

Effect of Mannose Receptor (MR)-binding polymers on human macrophages
by: de Medeiros Costa, Diego
Published: (2019)

Human dendritic cell sequestration onto the Necator americanus larval sheath during ex-sheathing: a possible mechanism for immune privilege
by: Hassan, A., et al.
Published: (2018)

Investigating the molecular basis of biased signalling at cannabinoid receptors
by: Dennis, Morgan Jane
Published: (2023)

Role of D1 receptor antagonism in contextual fear learning and memory
by: Heath, Florence
Published: (2015)

Using super resolution microscopy to investigate the role of actin in adenosine receptor organisation
by: Garlick, Evelyn
Published: (2023)

Medicinal Chemistry & Chemical Biology Approaches to Investigate Prospective Treatments for CNS Diseases: Dopamine D1 Receptor Positive Allosteric Modulators, Dopamine D2 Receptor Positive & Negative Allosteric Modulators, Dopamine D2 Receptor-Ligand Kinetics
by: Fyfe, Tim
Published: (2019)

Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors
by: Sykes, David A., et al.
Published: (2017)

Expression and regulation of immune-modulatory enzyme Indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation
by: Aldajani, Wejdan A., et al.
Published: (2016)

Subset-specific expression of toll-like receptors by bovine afferent lymph dendritic cells
by: Werling, Dirk, et al.
Published: (2017)

Molecular mechanisms controlling μ-opioid receptor activation
by: Batista Gondin, Arisbel
Published: (2019)

Oestrogen receptors in oesophageal cancer
by: De Rosa, Antonella
Published: (2018)

Characterisation of endogenous A2A and A2B receptor-mediated cyclic AMP responses in HEK 293 cells using the GloSensor™ biosensor: evidence for an allosteric mechanism of action for the A2B-selective antagonist PSB 603
by: Goulding, Joelle, et al.
Published: (2018)

Response of concentrate supplementation on ovulation rate and progesterone receptor gene in goats
by: Mohammed, Nur Hafizah
Published: (2018)

D-amphetamine and antipsychotic drug effects on latent inhibition in mice lacking dopamine D2 receptors
by: Bay-Richter, C., et al.
Published: (2013)

Investigating the inhibition of NMDA receptors by memantine and harmonine
by: Johnson, Eleanor
Published: (2023)

An evaluation of DREADD receptor pharmacology in recombinant cells and astrocytes
by: Carpenter, Jessica
Published: (2020)

Autoimmunity and effector recognition in Arabidopsis thaliana can be uncoupled by mutations in the RRS1-R immune receptor
by: Newman, Toby, et al.
Published: (2019)

Real-time analysis of the binding of fluorescent VEGF₁₆₅a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes
by: Kilpatrick, Laura E., et al.
Published: (2017)

Determination of agonist intrinsic efficacies at the dopamine D2 receptor
by: Stott, Lisa Alice
Published: (2017)

Release currents of IP₃ receptor channel clusters and concentration profiles
by: Thul, Ruediger, et al.
Published: (2004)

Toll-like receptors (TLRs) and T cell effector function
by: Mahmood, Majid Mohammed
Published: (2020)

From a4ß2 Nicotinic Ligands to the Discovery of σ1 Receptor Ligands: Pharmacophore Analysis and Rational Design
by: Yu, L., et al.
Published: (2012)

Biased allosteric modulators of metabotropic glutamate receptor 5
by: Sengmany, Kathy
Published: (2018)

Investigation of Harmonine inhibition of NMDA receptors
by: Brown Coker, Dennon-jay
Published: (2023)

Discovery of fevipiprant (NVP-QAW039), a potent and selective DP2 receptor antagonist for treatment of asthma
by: Sandham, David A., et al.
Published: (2017)

Agonist stimulus trafficking by human prostanoid CRTH2 (DP2) receptors.
by: McArthur Wilson, Richard John
Published: (2007)

Development of novel therapeutic agents designed to enhance insulin secretion through activation of the trace amine-associated receptor 1 (TAAR1)
by: Lenham, Rhianna
Published: (2025)

The effect of memantine and the ladybird alkaloid, harmonine, on NMDA receptor function and Alzheimer’s disease
by: Kaur, Kiran
Published: (2022)

Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist
by: Stoddart, Leigh A., et al.
Published: (2015)

A non-imaging high throughput approach to chemical library screening at the unmodified adenosine-A3 receptor in living cells
by: Arruda, Maria Augusta, et al.
Published: (2017)

The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA3 adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition
by: Cheong, S., et al.
Published: (2010)

Similarity- and substructure-based development of β2-adrenergic receptor ligands based on unusual scaffolds
by: Schmidt, Denis, et al.
Published: (2017)

A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS)
by: Negm, Ola H., et al.
Published: (2014)

UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery
by: Abbas, Zainab S.B., et al.
Published: (2018)

Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization
by: Hill, Stephen J., et al.
Published: (2014)