An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy
tThe human placenta is a critical life-support system that nourishes and protects a rapidly growing fetus; aunique organ, species specific in structure and function. We consider the pressing challenge of providingadditional advice on the safety of prescription medicines and environmental exposures i...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
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Elsevier
2016
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| Online Access: | https://eprints.nottingham.ac.uk/35673/ |
| _version_ | 1848795135006998528 |
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| author | Brownbill, Paul Chernyavsky, Igor Bottalico, Barbara Desoye, Gernot Hansson, Stefan Kenna, Gerry Knudsen, Lisbeth E. Markert, Udo R. Powles-Glover, Nicola Schneider, Henning Leach, Lopa |
| author_facet | Brownbill, Paul Chernyavsky, Igor Bottalico, Barbara Desoye, Gernot Hansson, Stefan Kenna, Gerry Knudsen, Lisbeth E. Markert, Udo R. Powles-Glover, Nicola Schneider, Henning Leach, Lopa |
| author_sort | Brownbill, Paul |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | tThe human placenta is a critical life-support system that nourishes and protects a rapidly growing fetus; aunique organ, species specific in structure and function. We consider the pressing challenge of providingadditional advice on the safety of prescription medicines and environmental exposures in pregnancy andhow ex vivo and in vitro human placental models might be advanced to reproducible human placentaltest systems (HPTSs), refining a weight of evidence to the guidance given around compound risk assess-ment during pregnancy. The placental pharmacokinetics of xenobiotic transfer, dysregulated placentalfunction in pregnancy-related pathologies and influx/efflux transporter polymorphisms are a few caveatsthat could be addressed by HPTSs, not the specific focus of current mammalian reproductive toxicologysystems. An international consortium, “PlaNet”, will bridge academia, industry and regulators to con-sider screen ability and standardisation issues surrounding these models, with proven reproducibilityfor introduction into industrial and clinical practice. |
| first_indexed | 2025-11-14T19:27:16Z |
| format | Article |
| id | nottingham-35673 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:27:16Z |
| publishDate | 2016 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-356732020-05-04T17:55:56Z https://eprints.nottingham.ac.uk/35673/ An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy Brownbill, Paul Chernyavsky, Igor Bottalico, Barbara Desoye, Gernot Hansson, Stefan Kenna, Gerry Knudsen, Lisbeth E. Markert, Udo R. Powles-Glover, Nicola Schneider, Henning Leach, Lopa tThe human placenta is a critical life-support system that nourishes and protects a rapidly growing fetus; aunique organ, species specific in structure and function. We consider the pressing challenge of providingadditional advice on the safety of prescription medicines and environmental exposures in pregnancy andhow ex vivo and in vitro human placental models might be advanced to reproducible human placentaltest systems (HPTSs), refining a weight of evidence to the guidance given around compound risk assess-ment during pregnancy. The placental pharmacokinetics of xenobiotic transfer, dysregulated placentalfunction in pregnancy-related pathologies and influx/efflux transporter polymorphisms are a few caveatsthat could be addressed by HPTSs, not the specific focus of current mammalian reproductive toxicologysystems. An international consortium, “PlaNet”, will bridge academia, industry and regulators to con-sider screen ability and standardisation issues surrounding these models, with proven reproducibilityfor introduction into industrial and clinical practice. Elsevier 2016-06-18 Article PeerReviewed Brownbill, Paul, Chernyavsky, Igor, Bottalico, Barbara, Desoye, Gernot, Hansson, Stefan, Kenna, Gerry, Knudsen, Lisbeth E., Markert, Udo R., Powles-Glover, Nicola, Schneider, Henning and Leach, Lopa (2016) An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy. Reproductive Toxicology . ISSN 0890-6238 PlaNet; Human placenta; Reproductive toxicology testing; 3Rs http://dx.doi.org/10.1016/j.reprotox.2016.06.006 doi:10.1016/j.reprotox.2016.06.006 doi:10.1016/j.reprotox.2016.06.006 |
| spellingShingle | PlaNet; Human placenta; Reproductive toxicology testing; 3Rs Brownbill, Paul Chernyavsky, Igor Bottalico, Barbara Desoye, Gernot Hansson, Stefan Kenna, Gerry Knudsen, Lisbeth E. Markert, Udo R. Powles-Glover, Nicola Schneider, Henning Leach, Lopa An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy |
| title | An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy |
| title_full | An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy |
| title_fullStr | An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy |
| title_full_unstemmed | An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy |
| title_short | An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy |
| title_sort | international network (planet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy |
| topic | PlaNet; Human placenta; Reproductive toxicology testing; 3Rs |
| url | https://eprints.nottingham.ac.uk/35673/ https://eprints.nottingham.ac.uk/35673/ https://eprints.nottingham.ac.uk/35673/ |