Glyceryl trinitrate for acute intracerebral hemorrhage: results from the efficacy of nitric oxide in stroke (ENOS) trial, a subgroup analysis

QR Code

Glyceryl trinitrate for acute intracerebral hemorrhage: results from the efficacy of nitric oxide in stroke (ENOS) trial, a subgroup analysis

Background and purpose: The Efficacy of Nitric oxide in Stroke (ENOS) trial found that transdermal glyceryl trinitrate (GTN, a nitric oxide donor) lowered blood pressure but did not improve functional outcome in patients with acute stroke. However, GTN was associated with improved outcome if patient...

Full description

Bibliographic Details
Main Authors:	Krishnan, Kailash, Scutt, Polly, Woodhouse, Lisa J., Adami, Alessandro, Becker, Jennifer L., Berge, Eivind, Cala, Lesley A., Casado, Ana M., Caso, Valeria, Chen, Christopher, Christensen, Hanna, Collins, Ronan, Czlonkowska, Anna, Dineen, Robert A., Gommans, John, Koumellis, Panos, Lees, Kennedy R., Ntaios, George, Ozturk, Serefnur, Phillips, Stephen J., Pocock, Stuart J., de Silva, Asita, Sprigg, Nikola, Szatmari, Szabolcs, Wardlaw, Joanna M., Bath, Philip M.W.
Format:	Article
Published:	American Heart Association 2015
Subjects:	Acute stroke; Antihypertensive therapy; Blood pressure; Glyceryl trinitrate; Intracerebral haemorrhage; Randomised controlled trial
Online Access:	https://eprints.nottingham.ac.uk/35601/

Similar Items

Route of feeding as a proxy for dysphagia after stroke and the effect of transdermal glyceryl trinitrate: data from the efficacy of nitric oxide in stroke randomised controlled trial
by: Woodhouse, Lisa J., et al.
Published: (2017)

Infections up to 76 days after stroke increase disability and death
by: Learoyd, Annastazia, et al.
Published: (2017)

Ambulance-delivered transdermal glyceryl trinitrate versus sham for ultra-acute stroke: rationale, design and protocol for the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) trial (ISRCTN26986053)
by: Appleton, Jason P., et al.
Published: (2017)

Statistical analysis plan for the ‘Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2)’
by: Scutt, Polly, et al.
Published: (2018)

Continuing versus stopping prestroke antihypertensive therapy in acute intracerebral hemorrhage: a subgroup analysis of the efficacy of nitric oxide in stroke trial
by: Krishnan, Kailash, et al.
Published: (2016)

Statistical analysis plan for the ‘Efficacy of Nitric Oxide in Stroke’ (ENOS) trial
by: Bath, Philip M.W., et al.
Published: (2014)

Effect of hyperacute administration (within 6 hours) of transdermal glyceryl trinitrate, a nitric oxide donor, on outcome after stroke
by: Woodhouse, Lisa J., et al.
Published: (2015)

Rapid intervention with glyceryl trinitrate in hypertensive stroke trial-2(right-2): safety and efficacy of transdermal glyceryl trinitrate, a nitric oxide donor
by: Dixon, M., et al.
Published: (2018)

Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2): safety and efficacy of transdermal glyceryl trinitrate, a nitric oxide donor, and of the feasibility of a multicentre ambulance-based stroke trial
by: Dixon, Mark, et al.
Published: (2018)

Therapeutic potential of transdermal glyceryl trinitrate in the management of acute stroke
by: Appleton, Jason P., et al.
Published: (2016)

Consent procedures and relationship with outcome in the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2)
by: Scutt, Polly, et al.
Published: (2018)

The role of glyceryl trinitrate, a nitric oxide donor, in acute stroke
by: Appleton, Jason Philip
Published: (2019)

Interim analysis of ambulance logistics and timings in patients recruited into the Rapid intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2)
by: Dixon, Mark, et al.
Published: (2018)

The effect of transdermal glyceryl trinitrate in acute stroke patients with carotid stenosis: data from the Efficacy of Nitric Oxide in Stroke trial
by: Appleton, J.P., et al.
Published: (2018)

Effect of treatment delay, stroke type, and thrombolysis on the effect of glyceryl trinitrate, a nitric oxide donor, on outcome after acute stroke: a systematic review and meta-analysis of individual patient from randomised trials
by: Bath, Philip M.W., et al.
Published: (2016)

The effect of transdermal glyceryl trinitrate on imaging characteristics in acute ischaemic stroke: data from the Efficacy of Nitric Oxide in Stroke trial
by: Appleton, Jason P.
Published: (2018)

Impact of ultra/hyper-acute administration of glyceryl trinitrate on secondary outcome after acute stroke: a meta-analysis of individual patient data from randomised trials
by: Bath, Philip M., et al.
Published: (2018)

Relationship between race and outcome in Asian, Black and Caucasian patients with spontaneous intracerebral haemorrhage: data from the Virtual International Stroke Trials Archive (VISTA) and Efficacy of Nitric Oxide in Stroke trial (ENOS)
by: Krishnan, Kailash, et al.
Published: (2018)

Glyceryl ether (mono-tert-butoxypropanediol) in emulsion system
by: Yusrabbil Amiyati Yusof,, et al.
Published: (2018)

Testing of glyceryl monoesters for their antimicrobial susceptibility and their influence in emulsions.
by: Loo, Chew Hung, et al.
Published: (2010)

Quercetin and its metabolites improve vessel function by inducing eNOS activity via phosphorylation of AMPK
by: Shen, Y., et al.
Published: (2012)

Influence of soya lecithin, sorbitan and glyceryl monostearate on physicochemical properties of organogels
by: Sheah, Yee Ghan, et al.
Published: (2020)

Palm olein organogelation using mixtures of soy lecithin and glyceryl monostearate
by: Ghan, Sheah Yee, et al.
Published: (2022)

Vitamins Reverse Endothelial Dysfunction Through Regulation of eNOS and NAD(P)H Oxidase Activities
by: Ulker, Sible, et al.
Published: (2003)

Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia
by: Smith-Jackson, Kate, et al.
Published: (2015)

Characterization of bismuth oxide catalysts prepared from bismuth trinitrate pentahydrate: influence of bismuth concentration
by: Ramli, Irmawati, et al.
Published: (2004)

A case-control study and meta-analysis of the association of eNOS rs1799983 SNP with stroke risk
by: Phneh, KY, et al.
Published: (2019)

Deep Eutectic Solvent (Des) As A New Solvent For Lipase-Catalyzed Synthesis Of Glyceryl Monocaffeate Via Transesterification
by: Bakar, Puteri Norathirah Megat Abu
Published: (2019)

Deep Eutectic Solvent (Des) As A New Solvent For Lipase-Catalyzed Synthesis Of Glyceryl Monocaffeate Via Transesterification
by: Bakar, Puteri Norathirah Megat Abu
Published: (2019)

Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial
by: Bath, Philip M.W.
Published: (2015)

How Do Young Adults Develop Preferences Towards Clothing Retail Stores?
by: Kuruppu, Asita
Published: (2012)

Enolase in Meyerozyma guilliermondii strain SO: sequential and structural insights of MgEno4581 as a putative virulence factor and host-fungal interactions through comprehensive in silico approaches
by: Amran, Alia Iwani, et al.
Published: (2023)

Drawing Representation in Design
by: Scutt, Sarah
Published: (2006)

Renoprotective and antihypertensive mechanism of action of Clinacanthus nutans bioactive polysaccharides by suppression of reactive oxygen species/ nuclear factor/ matrix metalloproteinase (ROS/NF-ΚB/MMP-9) and upregulation of endothelial nitric oxide synthase/nitric oxide (eNOS/NO) pathways
by: Chia, Tan Yong, et al.
Published: (2025)

Statistical analysis plan for the ‘Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage’ (TICH-2) trial
by: Flaherty, Katie, et al.
Published: (2017)

Continuing or temporarily stopping prestroke antihypertensive medication in acute stroke: an individual patient data meta-analysis
by: Woodhouse, Lisa J., et al.
Published: (2017)

Analysis and Material Selection of a Continuously Variable Transmission (CVT) for a Bicycle Drivetrain
by: Pramanik, Alokesh, et al.
Published: (2018)

Natural Gas Vehicle (NGV) / Roslan Said and Mohd Adami Muda
by: Said, Roslan, et al.
Published: (2002)

The origins, development and significance of the circuit in Wesleyan and primitive Methodism in England 1740-1914
by: Pocock, Christine Margaret
Published: (2015)

Increasing value and reducing waste in stroke research
by: Berge, Eivind, et al.
Published: (2017)