Is speed of healing a good predictor of eventual healing of pyoderma gangrenosum?
Background: Pyoderma gangrenosum is a rare inflammatory skin condition. The STOPGAP studies compared treatments for pyoderma gangrenosum using a primary outcome of healing speed at 6 weeks. Objective: Using data from both studies we assessed the predictive value of three early predictors for healin...
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| Format: | Article |
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Elsevier
2016
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| Online Access: | https://eprints.nottingham.ac.uk/35520/ |
| _version_ | 1848795097439666176 |
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| author | Wilkes, Sally R. Williams, Hywel C. Ormerod, Anthony D. Craig, Fiona E. Greenlaw, Nicola Norrie, John Mitchell, Eleanor Mason, James M. Thomas, Kim S. |
| author_facet | Wilkes, Sally R. Williams, Hywel C. Ormerod, Anthony D. Craig, Fiona E. Greenlaw, Nicola Norrie, John Mitchell, Eleanor Mason, James M. Thomas, Kim S. |
| author_sort | Wilkes, Sally R. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background: Pyoderma gangrenosum is a rare inflammatory skin condition. The STOPGAP studies compared treatments for pyoderma gangrenosum using a primary outcome of healing speed at 6 weeks.
Objective: Using data from both studies we assessed the predictive value of three early predictors for healing at 6 months - speed of healing, Investigator Global Assessment and resolution of inflammation, recorded at 2 and 6 weeks.
Methods: Logistic regression models were applied and the effectiveness of the three measures was assessed through estimating the positive (PPV) and negative predictive values (NPV) and the area under the receiver operating characteristic curve (AUC).
Results: The PPV and NPV at 6 weeks were 63.5% (95% CI:52.4%, 73.7%) and 74.6% (95% CI:62.5%, 84.5%) respectively for speed of healing; 80% (95% CI:68.7%, 88.6%) and 74.2% (95% CI:64.1%, 2.7%) for IGA; and 72.1% (95% CI:59.9%, 82.3%) and 68.1% (95% CI:57.7%, 77.3%) for resolution of inflammation. Investigator Global Assessment had the best combined PPV, NPV and AUC at 2 and 6 weeks.
Limitations: We were limited by data available from the STOP GAP trial and cohort study.
Conclusion: Speed of healing, Investigator Global Assessment and resolution of inflammation were all shown to be good predictors of eventual healing. |
| first_indexed | 2025-11-14T19:26:40Z |
| format | Article |
| id | nottingham-35520 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:26:40Z |
| publishDate | 2016 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-355202020-05-04T18:17:33Z https://eprints.nottingham.ac.uk/35520/ Is speed of healing a good predictor of eventual healing of pyoderma gangrenosum? Wilkes, Sally R. Williams, Hywel C. Ormerod, Anthony D. Craig, Fiona E. Greenlaw, Nicola Norrie, John Mitchell, Eleanor Mason, James M. Thomas, Kim S. Background: Pyoderma gangrenosum is a rare inflammatory skin condition. The STOPGAP studies compared treatments for pyoderma gangrenosum using a primary outcome of healing speed at 6 weeks. Objective: Using data from both studies we assessed the predictive value of three early predictors for healing at 6 months - speed of healing, Investigator Global Assessment and resolution of inflammation, recorded at 2 and 6 weeks. Methods: Logistic regression models were applied and the effectiveness of the three measures was assessed through estimating the positive (PPV) and negative predictive values (NPV) and the area under the receiver operating characteristic curve (AUC). Results: The PPV and NPV at 6 weeks were 63.5% (95% CI:52.4%, 73.7%) and 74.6% (95% CI:62.5%, 84.5%) respectively for speed of healing; 80% (95% CI:68.7%, 88.6%) and 74.2% (95% CI:64.1%, 2.7%) for IGA; and 72.1% (95% CI:59.9%, 82.3%) and 68.1% (95% CI:57.7%, 77.3%) for resolution of inflammation. Investigator Global Assessment had the best combined PPV, NPV and AUC at 2 and 6 weeks. Limitations: We were limited by data available from the STOP GAP trial and cohort study. Conclusion: Speed of healing, Investigator Global Assessment and resolution of inflammation were all shown to be good predictors of eventual healing. Elsevier 2016-10-11 Article PeerReviewed Wilkes, Sally R., Williams, Hywel C., Ormerod, Anthony D., Craig, Fiona E., Greenlaw, Nicola, Norrie, John, Mitchell, Eleanor, Mason, James M. and Thomas, Kim S. (2016) Is speed of healing a good predictor of eventual healing of pyoderma gangrenosum? Journal of the American Academy of Dermatology, 75 (6). 1216-1220.e2. ISSN 1097-6787 Pyoderma Gangrenosum Speed of Healing Lesion Improvement Resolution of Inflammation Predictors Clinical Trials Clinical Practice http://www.sciencedirect.com/science/article/pii/S0190962216306016 doi:10.1016/j.jaad.2016.07.049 doi:10.1016/j.jaad.2016.07.049 |
| spellingShingle | Pyoderma Gangrenosum Speed of Healing Lesion Improvement Resolution of Inflammation Predictors Clinical Trials Clinical Practice Wilkes, Sally R. Williams, Hywel C. Ormerod, Anthony D. Craig, Fiona E. Greenlaw, Nicola Norrie, John Mitchell, Eleanor Mason, James M. Thomas, Kim S. Is speed of healing a good predictor of eventual healing of pyoderma gangrenosum? |
| title | Is speed of healing a good predictor of eventual healing of pyoderma gangrenosum? |
| title_full | Is speed of healing a good predictor of eventual healing of pyoderma gangrenosum? |
| title_fullStr | Is speed of healing a good predictor of eventual healing of pyoderma gangrenosum? |
| title_full_unstemmed | Is speed of healing a good predictor of eventual healing of pyoderma gangrenosum? |
| title_short | Is speed of healing a good predictor of eventual healing of pyoderma gangrenosum? |
| title_sort | is speed of healing a good predictor of eventual healing of pyoderma gangrenosum? |
| topic | Pyoderma Gangrenosum Speed of Healing Lesion Improvement Resolution of Inflammation Predictors Clinical Trials Clinical Practice |
| url | https://eprints.nottingham.ac.uk/35520/ https://eprints.nottingham.ac.uk/35520/ https://eprints.nottingham.ac.uk/35520/ |