The Insulin Resistance Intervention after Stroke trial: a perspective on future practice and research
The prevention of recurrent events after ischaemic stroke and transient ischaemic attack is well established and based on lifestyle changes, antithrombotics, statins, antihypertensives and carotid surgery. The international IRIS trial assessed whether pioglitazone, a glucose-lowering insulin-sensiti...
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| Format: | Article |
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SAGE Publications
2016
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| Online Access: | https://eprints.nottingham.ac.uk/35498/ |
| _version_ | 1848795093159378944 |
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| author | Bath, Philip M.W. Appleton, Jason P. Sprigg, Nikola |
| author_facet | Bath, Philip M.W. Appleton, Jason P. Sprigg, Nikola |
| author_sort | Bath, Philip M.W. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The prevention of recurrent events after ischaemic stroke and transient ischaemic attack is well established and based on lifestyle changes, antithrombotics, statins, antihypertensives and carotid surgery. The international IRIS trial assessed whether pioglitazone, a glucose-lowering insulin-sensitizing drug, would reduce recurrent vascular events in patients with ischaemic stroke or transient ischaemic attack. After 4.8 years, pioglitazone therapy was associated with reduced vascular events and new diabetes, and an increase in weight, oedema and bone fractures. Pioglitazone may add to the strategies for preventing further events in patients with stroke or transient ischaemic attack. |
| first_indexed | 2025-11-14T19:26:36Z |
| format | Article |
| id | nottingham-35498 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:26:36Z |
| publishDate | 2016 |
| publisher | SAGE Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-354982020-05-04T18:01:48Z https://eprints.nottingham.ac.uk/35498/ The Insulin Resistance Intervention after Stroke trial: a perspective on future practice and research Bath, Philip M.W. Appleton, Jason P. Sprigg, Nikola The prevention of recurrent events after ischaemic stroke and transient ischaemic attack is well established and based on lifestyle changes, antithrombotics, statins, antihypertensives and carotid surgery. The international IRIS trial assessed whether pioglitazone, a glucose-lowering insulin-sensitizing drug, would reduce recurrent vascular events in patients with ischaemic stroke or transient ischaemic attack. After 4.8 years, pioglitazone therapy was associated with reduced vascular events and new diabetes, and an increase in weight, oedema and bone fractures. Pioglitazone may add to the strategies for preventing further events in patients with stroke or transient ischaemic attack. SAGE Publications 2016-07-12 Article PeerReviewed Bath, Philip M.W., Appleton, Jason P. and Sprigg, Nikola (2016) The Insulin Resistance Intervention after Stroke trial: a perspective on future practice and research. International Journal of Stroke . ISSN 1747-4949 Prevention Ischaemic Stroke Clinical Trial Stroke Treatment Vascular Events http://wso.sagepub.com/content/early/2016/07/12/1747493016660099 doi:10.1177/1747493016660099 doi:10.1177/1747493016660099 |
| spellingShingle | Prevention Ischaemic Stroke Clinical Trial Stroke Treatment Vascular Events Bath, Philip M.W. Appleton, Jason P. Sprigg, Nikola The Insulin Resistance Intervention after Stroke trial: a perspective on future practice and research |
| title | The Insulin Resistance Intervention after Stroke trial: a perspective on future practice and research |
| title_full | The Insulin Resistance Intervention after Stroke trial: a perspective on future practice and research |
| title_fullStr | The Insulin Resistance Intervention after Stroke trial: a perspective on future practice and research |
| title_full_unstemmed | The Insulin Resistance Intervention after Stroke trial: a perspective on future practice and research |
| title_short | The Insulin Resistance Intervention after Stroke trial: a perspective on future practice and research |
| title_sort | insulin resistance intervention after stroke trial: a perspective on future practice and research |
| topic | Prevention Ischaemic Stroke Clinical Trial Stroke Treatment Vascular Events |
| url | https://eprints.nottingham.ac.uk/35498/ https://eprints.nottingham.ac.uk/35498/ https://eprints.nottingham.ac.uk/35498/ |