Computational modeling of the effects of auditory nerve dysmyelination
Our previous study showed that exposure to loud sound leading to hearing loss elongated the auditory nerve (AN) nodes of Ranvier and triggered notable morphological changes at paranodes and juxtaparanodes. Here we used computational modeling to examine how theoretical redistribution of voltage gated...
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| Format: | Article |
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Frontiers Media
2014
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| Online Access: | https://eprints.nottingham.ac.uk/35377/ |
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| author | Brown, Angus M. Hamann, Martine |
| author_facet | Brown, Angus M. Hamann, Martine |
| author_sort | Brown, Angus M. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Our previous study showed that exposure to loud sound leading to hearing loss elongated the auditory nerve (AN) nodes of Ranvier and triggered notable morphological changes at paranodes and juxtaparanodes. Here we used computational modeling to examine how theoretical redistribution of voltage gated Na+, Kv3.1, and Kv1.1 channels along the AN may be responsible for the alterations of conduction property following acoustic over-exposure. Our modeling study infers that changes related to Na+ channel density (rather than the redistribution of voltage gated Na+, Kv3.1, and Kv1.1 channels) is the likely cause of the decreased conduction velocity and the conduction block observed after acoustic overexposure (AOE). |
| first_indexed | 2025-11-14T19:26:08Z |
| format | Article |
| id | nottingham-35377 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:26:08Z |
| publishDate | 2014 |
| publisher | Frontiers Media |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-353772020-05-04T16:49:58Z https://eprints.nottingham.ac.uk/35377/ Computational modeling of the effects of auditory nerve dysmyelination Brown, Angus M. Hamann, Martine Our previous study showed that exposure to loud sound leading to hearing loss elongated the auditory nerve (AN) nodes of Ranvier and triggered notable morphological changes at paranodes and juxtaparanodes. Here we used computational modeling to examine how theoretical redistribution of voltage gated Na+, Kv3.1, and Kv1.1 channels along the AN may be responsible for the alterations of conduction property following acoustic over-exposure. Our modeling study infers that changes related to Na+ channel density (rather than the redistribution of voltage gated Na+, Kv3.1, and Kv1.1 channels) is the likely cause of the decreased conduction velocity and the conduction block observed after acoustic overexposure (AOE). Frontiers Media 2014-08-01 Article PeerReviewed Brown, Angus M. and Hamann, Martine (2014) Computational modeling of the effects of auditory nerve dysmyelination. Frontiers in Neuroanatomy, 8 (73). pp. 1-7. ISSN 1662-5129 myelin sheath hearing loss node of Ranvier conduction velocity conduction block deafness myelin domains action potential http://journal.frontiersin.org/article/10.3389/fnana.2014.00073/full doi:10.3389/fnana.2014.00073 doi:10.3389/fnana.2014.00073 |
| spellingShingle | myelin sheath hearing loss node of Ranvier conduction velocity conduction block deafness myelin domains action potential Brown, Angus M. Hamann, Martine Computational modeling of the effects of auditory nerve dysmyelination |
| title | Computational modeling of the effects of auditory nerve dysmyelination |
| title_full | Computational modeling of the effects of auditory nerve dysmyelination |
| title_fullStr | Computational modeling of the effects of auditory nerve dysmyelination |
| title_full_unstemmed | Computational modeling of the effects of auditory nerve dysmyelination |
| title_short | Computational modeling of the effects of auditory nerve dysmyelination |
| title_sort | computational modeling of the effects of auditory nerve dysmyelination |
| topic | myelin sheath hearing loss node of Ranvier conduction velocity conduction block deafness myelin domains action potential |
| url | https://eprints.nottingham.ac.uk/35377/ https://eprints.nottingham.ac.uk/35377/ https://eprints.nottingham.ac.uk/35377/ |