Insight into the relationship between the cell culture model, cell trafficking and siRNA silencing efficiency

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Insight into the relationship between the cell culture model, cell trafficking and siRNA silencing efficiency

Despite research efforts, cell uptake processes determining siRNA silencing efficiency remain unclear. Here, we examine the relationship between in vitro cell culture models, cellular trafficking and siRNA silencing efficiency to provide a mechanistic insight on siRNA delivery system design. Model s...

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Bibliographic Details
Main Authors:	Capel, Victoria, Vllasaliu, Driton, Watts, Peter, Stolnik, Snow
Format:	Article
Published:	Elsevier 2016
Subjects:	Endocytosis pathways; Lung siRNA therapy; Pharmacological inhibitors; siRNA polyplexes; siRNA silencing
Online Access:	https://eprints.nottingham.ac.uk/35333/

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