Synthesis of triazole-linked morpholino oligonucleotides via Cu1 catalysed cycloaddition

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Synthesis of triazole-linked morpholino oligonucleotides via Cu1 catalysed cycloaddition

Triazole-linked morpholino (TLMO) oligonucleic acids were synthesised using the CuI catalysed (3 + 2) azide–alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the TLMO modification gi...

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Bibliographic Details
Main Authors:	Palframan, Matthew J., Alharthy, Rima D., Powalowska, Paulina K., Hayes, Christopher J.
Format:	Article
Published:	Royal Society of Chemistry 2016
Online Access:	https://eprints.nottingham.ac.uk/35070/

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