Synthesis of triazole-linked morpholino oligonucleotides via Cu1 catalysed cycloaddition
Triazole-linked morpholino (TLMO) oligonucleic acids were synthesised using the CuI catalysed (3 + 2) azide–alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the TLMO modification gi...
| Main Authors: | , , , |
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| Format: | Article |
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Royal Society of Chemistry
2016
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| Online Access: | https://eprints.nottingham.ac.uk/35070/ |
| _version_ | 1848794996685144064 |
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| author | Palframan, Matthew J. Alharthy, Rima D. Powalowska, Paulina K. Hayes, Christopher J. |
| author_facet | Palframan, Matthew J. Alharthy, Rima D. Powalowska, Paulina K. Hayes, Christopher J. |
| author_sort | Palframan, Matthew J. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Triazole-linked morpholino (TLMO) oligonucleic acids were synthesised using the CuI catalysed (3 + 2) azide–alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the TLMO modification gives higher Tm values than the corresponding TLDNA modification. |
| first_indexed | 2025-11-14T19:25:04Z |
| format | Article |
| id | nottingham-35070 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:25:04Z |
| publishDate | 2016 |
| publisher | Royal Society of Chemistry |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-350702020-05-04T17:36:55Z https://eprints.nottingham.ac.uk/35070/ Synthesis of triazole-linked morpholino oligonucleotides via Cu1 catalysed cycloaddition Palframan, Matthew J. Alharthy, Rima D. Powalowska, Paulina K. Hayes, Christopher J. Triazole-linked morpholino (TLMO) oligonucleic acids were synthesised using the CuI catalysed (3 + 2) azide–alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the TLMO modification gives higher Tm values than the corresponding TLDNA modification. Royal Society of Chemistry 2016-02-16 Article PeerReviewed Palframan, Matthew J., Alharthy, Rima D., Powalowska, Paulina K. and Hayes, Christopher J. (2016) Synthesis of triazole-linked morpholino oligonucleotides via Cu1 catalysed cycloaddition. Organic and Biomolecular Chemistry, 14 . pp. 3112-3119. ISSN 1477-0520 http://dx.doi.org/10.1039/C6OB00007J 10.1039/C6OB00007J 10.1039/C6OB00007J 10.1039/C6OB00007J |
| spellingShingle | Palframan, Matthew J. Alharthy, Rima D. Powalowska, Paulina K. Hayes, Christopher J. Synthesis of triazole-linked morpholino oligonucleotides via Cu1 catalysed cycloaddition |
| title | Synthesis of triazole-linked morpholino oligonucleotides via Cu1 catalysed cycloaddition |
| title_full | Synthesis of triazole-linked morpholino oligonucleotides via Cu1 catalysed cycloaddition |
| title_fullStr | Synthesis of triazole-linked morpholino oligonucleotides via Cu1 catalysed cycloaddition |
| title_full_unstemmed | Synthesis of triazole-linked morpholino oligonucleotides via Cu1 catalysed cycloaddition |
| title_short | Synthesis of triazole-linked morpholino oligonucleotides via Cu1 catalysed cycloaddition |
| title_sort | synthesis of triazole-linked morpholino oligonucleotides via cu1 catalysed cycloaddition |
| url | https://eprints.nottingham.ac.uk/35070/ https://eprints.nottingham.ac.uk/35070/ https://eprints.nottingham.ac.uk/35070/ |