Synthesis of triazole-linked morpholino oligonucleotides via Cu1 catalysed cycloaddition
Triazole-linked morpholino (TLMO) oligonucleic acids were synthesised using the CuI catalysed (3 + 2) azide–alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the TLMO modification gi...
| Main Authors: | , , , |
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| Format: | Article |
| Published: |
Royal Society of Chemistry
2016
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| Online Access: | https://eprints.nottingham.ac.uk/35070/ |
| Summary: | Triazole-linked morpholino (TLMO) oligonucleic acids were synthesised using the CuI catalysed (3 + 2) azide–alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the TLMO modification gives higher Tm values than the corresponding TLDNA modification. |
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