Neuron-immune mechanisms contribute to pain in early stages of arthritis

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Neuron-immune mechanisms contribute to pain in early stages of arthritis

Background: Rheumatoid arthritis (RA) patients frequently show weak correlations between the magnitude of pain and inflammation suggesting that mechanisms other than overt peripheral inflammation contribute to pain in RA. We assessed changes in microglial reactivity and spinal excitability and their...

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Bibliographic Details
Main Authors:	Nieto, Francisco R., Clark, Anna K., Grist, John, Hathway, Gareth J., Chapman, Victoria, Malcangio, Marzia
Format:	Article
Published:	BioMed Central 2016
Subjects:	Collagen-induced arthritis ; Pain; EMG ; Microglia ; IL-1β ; Cathepsin S ; P2X7 receptor
Online Access:	https://eprints.nottingham.ac.uk/35037/

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