| Summary: | Background: Multiple sclerosis (MS) is a neurological conditioncharacterised by an unpredictable nature. This characteristic is reported to be the largest challenge for individuals with the condition. Chronic illness literature highlights the psychological impact of unpredictability, but there is a paucity of research examining this concept in MS.
Objectives: This systematic review aimed to explore the psychological impact of unpredictability in MS.
Methods: A meta-synthesis was conducted. A total of 6 studies with 59 participants were reviewed and critically appraised. Themes relating to the psychological impact of unpredictability were extracted and synthesised.
Results: A preliminary model of the unpredictability of MS was developed highlighting the different psychological impacts of diagnosis, remission and relapse.
Conclusions: The psychological impact of unpredictability alters through diagnosis, remission and relapse. Further research is required to explore the experience of unpredictability in MS.
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