An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids
We describe the identification in aphids of a unique heterodimeric voltage-gated sodium channel which has an atypical ion selectivity filter and, unusually for insect channels, is highly insensitive to tetrodotoxin. We demonstrate that this channel has most likely arisen by adaptation (gene fission...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
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Wiley
2015
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| Online Access: | https://eprints.nottingham.ac.uk/34979/ |
| _version_ | 1848794975447285760 |
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| author | Amey, Joanna S. O'Reilly, Andrias O. Burton, Mark J. Puinean, Alin M. Mellor, Ian R. Duce, Ian R. Field, Linda M. Wallace, B.A. Williamson, Martin S. Davies, T.G. Emyr |
| author_facet | Amey, Joanna S. O'Reilly, Andrias O. Burton, Mark J. Puinean, Alin M. Mellor, Ian R. Duce, Ian R. Field, Linda M. Wallace, B.A. Williamson, Martin S. Davies, T.G. Emyr |
| author_sort | Amey, Joanna S. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | We describe the identification in aphids of a unique heterodimeric voltage-gated sodium channel which has an atypical ion selectivity filter and, unusually for insect channels, is highly insensitive to tetrodotoxin. We demonstrate that this channel has most likely arisen by adaptation (gene fission or duplication) of an invertebrate ancestral mono(hetero)meric channel. This is the only identifiable voltage-gated sodium channel homologue in the aphid genome(s), and the channel's novel selectivity filter motif (DENS instead of the usual DEKA found in other eukaryotes) may result in a loss of sodium selectivity, as indicated experimentally in mutagenised Drosophila channels. |
| first_indexed | 2025-11-14T19:24:44Z |
| format | Article |
| id | nottingham-34979 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:24:44Z |
| publishDate | 2015 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-349792020-05-04T17:01:56Z https://eprints.nottingham.ac.uk/34979/ An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids Amey, Joanna S. O'Reilly, Andrias O. Burton, Mark J. Puinean, Alin M. Mellor, Ian R. Duce, Ian R. Field, Linda M. Wallace, B.A. Williamson, Martin S. Davies, T.G. Emyr We describe the identification in aphids of a unique heterodimeric voltage-gated sodium channel which has an atypical ion selectivity filter and, unusually for insect channels, is highly insensitive to tetrodotoxin. We demonstrate that this channel has most likely arisen by adaptation (gene fission or duplication) of an invertebrate ancestral mono(hetero)meric channel. This is the only identifiable voltage-gated sodium channel homologue in the aphid genome(s), and the channel's novel selectivity filter motif (DENS instead of the usual DEKA found in other eukaryotes) may result in a loss of sodium selectivity, as indicated experimentally in mutagenised Drosophila channels. Wiley 2015-02-27 Article PeerReviewed Amey, Joanna S., O'Reilly, Andrias O., Burton, Mark J., Puinean, Alin M., Mellor, Ian R., Duce, Ian R., Field, Linda M., Wallace, B.A., Williamson, Martin S. and Davies, T.G. Emyr (2015) An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids. FEBS Letters, 589 (5). pp. 598-607. ISSN 1873-3468 Voltage-gated sodium channel Aphid Evolution Tetrodotoxin http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2015.01.020/abstract doi:10.1016/j.febslet.2015.01.020 doi:10.1016/j.febslet.2015.01.020 |
| spellingShingle | Voltage-gated sodium channel Aphid Evolution Tetrodotoxin Amey, Joanna S. O'Reilly, Andrias O. Burton, Mark J. Puinean, Alin M. Mellor, Ian R. Duce, Ian R. Field, Linda M. Wallace, B.A. Williamson, Martin S. Davies, T.G. Emyr An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids |
| title | An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids |
| title_full | An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids |
| title_fullStr | An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids |
| title_full_unstemmed | An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids |
| title_short | An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids |
| title_sort | evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids |
| topic | Voltage-gated sodium channel Aphid Evolution Tetrodotoxin |
| url | https://eprints.nottingham.ac.uk/34979/ https://eprints.nottingham.ac.uk/34979/ https://eprints.nottingham.ac.uk/34979/ |