Stereoselective synthesis of functionalized pyrrolidines by the diverted NH insertion reaction of metallocarbenes with β-aminoketone derivatives

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Stereoselective synthesis of functionalized pyrrolidines by the diverted NH insertion reaction of metallocarbenes with β-aminoketone derivatives

A highly stereoselective route to functionalized pyrrolidines from the metal catalyzed diverted N-H insertion of a range of diazocarbonyl compounds with β-aminoketone derivatives is described. A number of catalysts (rhodium(II) carboxylate dimers, copper(I) triflate and an iron(III)porphyrin) are sh...

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Bibliographic Details
Main Authors:	Nicolle, Simon M., Lewis, William, Hayes, Christopher J., Moody, Christopher J.
Format:	Article
Published:	Wiley-VCH Verlag 2016
Subjects:	Aldol reaction; carbenes; diazo compounds; nitrogen heterocycles; transition-metal catalysis
Online Access:	https://eprints.nottingham.ac.uk/34962/

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