Total synthesis of the post-translationally modified polyazole peptide antibiotic plantazolicin A

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Total synthesis of the post-translationally modified polyazole peptide antibiotic plantazolicin A

The power of rhodium carbene methodology in chemistry is demonstrated by the synthesis of a structurally complex polyazole antibiotic. Plantazolicin A, a novel soil bacterium metabolite, comprises a linear array of 10 five-membered rings in two pentacyclic regions that derive from ribosomal peptide...

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Bibliographic Details
Main Authors:	Wada, Hiroki, Williams, Huw E. L., Moody, Christopher J.
Format:	Article
Published:	Wiley-VCH Verlag 2015
Subjects:	Antibiotics; carbenes; diazo compounds; heterocycles; total synthesis
Online Access:	https://eprints.nottingham.ac.uk/34953/

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