Surgical lung biopsy for the diagnosis of interstitial lung disease in England: 1997-2008
Introduction: International guidelines and new targeted therapies for idiopathic pulmonary fibrosis have increased the need for accurate diagnosis of interstitial lung disease, which may lead to more surgical lung biopsies. This study aims to assess the risk of this procedure in patients from the Un...
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| Format: | Article |
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European Respiratory Society
2016
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| Online Access: | https://eprints.nottingham.ac.uk/34719/ |
| _version_ | 1848794919941963776 |
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| author | Hutchinson, John P. McKeever, Tricia M. Fogarty, Andrew W. Navaratnam, Vidya Hubbard, Richard B. |
| author_facet | Hutchinson, John P. McKeever, Tricia M. Fogarty, Andrew W. Navaratnam, Vidya Hubbard, Richard B. |
| author_sort | Hutchinson, John P. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Introduction: International guidelines and new targeted therapies for idiopathic pulmonary fibrosis have increased the need for accurate diagnosis of interstitial lung disease, which may lead to more surgical lung biopsies. This study aims to assess the risk of this procedure in patients from the United Kingdom.
Methods: We used Hospital Episodes Statistics data from 1997-2008 to assess the frequency of surgical lung biopsy for interstitial lung disease in England. We identified cardiothoracic surgical patients using ICD-10 codes for interstitial lung disease and OPCS-4 codes for surgical lung biopsy. We excluded those with lung resections or lung cancer. We estimated in-hospital, 30-day and 90-day mortality following the procedure, and linked to cause of death using data from the Office of National Statistics.
Results: We identified 2,820 patients with interstitial lung disease undergoing surgical lung biopsy during the 12 year period. The number of biopsies increased over the time period studied. In-hospital, 30-day and 90-day mortality were 1.7%, 2.4% and 3.9% respectively. Male sex, increasing age, increasing co-morbidity and open surgery were risk factors for mortality.
Discussion: Surgical lung biopsy for interstitial lung disease has a similar mortality to lobectomy for lung cancer, and clinicians and patients should understand the likely risks involved. |
| first_indexed | 2025-11-14T19:23:51Z |
| format | Article |
| id | nottingham-34719 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:23:51Z |
| publishDate | 2016 |
| publisher | European Respiratory Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-347192020-05-04T18:10:03Z https://eprints.nottingham.ac.uk/34719/ Surgical lung biopsy for the diagnosis of interstitial lung disease in England: 1997-2008 Hutchinson, John P. McKeever, Tricia M. Fogarty, Andrew W. Navaratnam, Vidya Hubbard, Richard B. Introduction: International guidelines and new targeted therapies for idiopathic pulmonary fibrosis have increased the need for accurate diagnosis of interstitial lung disease, which may lead to more surgical lung biopsies. This study aims to assess the risk of this procedure in patients from the United Kingdom. Methods: We used Hospital Episodes Statistics data from 1997-2008 to assess the frequency of surgical lung biopsy for interstitial lung disease in England. We identified cardiothoracic surgical patients using ICD-10 codes for interstitial lung disease and OPCS-4 codes for surgical lung biopsy. We excluded those with lung resections or lung cancer. We estimated in-hospital, 30-day and 90-day mortality following the procedure, and linked to cause of death using data from the Office of National Statistics. Results: We identified 2,820 patients with interstitial lung disease undergoing surgical lung biopsy during the 12 year period. The number of biopsies increased over the time period studied. In-hospital, 30-day and 90-day mortality were 1.7%, 2.4% and 3.9% respectively. Male sex, increasing age, increasing co-morbidity and open surgery were risk factors for mortality. Discussion: Surgical lung biopsy for interstitial lung disease has a similar mortality to lobectomy for lung cancer, and clinicians and patients should understand the likely risks involved. European Respiratory Society 2016-09-22 Article PeerReviewed Hutchinson, John P., McKeever, Tricia M., Fogarty, Andrew W., Navaratnam, Vidya and Hubbard, Richard B. (2016) Surgical lung biopsy for the diagnosis of interstitial lung disease in England: 1997-2008. European Respiratory Journal, 48 . pp. 1453-1461. ISSN 1399-3003 Idiopathic Pulmonary Fibrosis Interstitial Lung Disease Surgical Lung Biopsy Mortality http://erj.ersjournals.com/content/early/2016/09/22/13993003.00378-2016 doi:10.1183/13993003.00378-2016 doi:10.1183/13993003.00378-2016 |
| spellingShingle | Idiopathic Pulmonary Fibrosis Interstitial Lung Disease Surgical Lung Biopsy Mortality Hutchinson, John P. McKeever, Tricia M. Fogarty, Andrew W. Navaratnam, Vidya Hubbard, Richard B. Surgical lung biopsy for the diagnosis of interstitial lung disease in England: 1997-2008 |
| title | Surgical lung biopsy for the diagnosis of interstitial lung disease in England: 1997-2008 |
| title_full | Surgical lung biopsy for the diagnosis of interstitial lung disease in England: 1997-2008 |
| title_fullStr | Surgical lung biopsy for the diagnosis of interstitial lung disease in England: 1997-2008 |
| title_full_unstemmed | Surgical lung biopsy for the diagnosis of interstitial lung disease in England: 1997-2008 |
| title_short | Surgical lung biopsy for the diagnosis of interstitial lung disease in England: 1997-2008 |
| title_sort | surgical lung biopsy for the diagnosis of interstitial lung disease in england: 1997-2008 |
| topic | Idiopathic Pulmonary Fibrosis Interstitial Lung Disease Surgical Lung Biopsy Mortality |
| url | https://eprints.nottingham.ac.uk/34719/ https://eprints.nottingham.ac.uk/34719/ https://eprints.nottingham.ac.uk/34719/ |