Symbiotic and antibiotic interactions between gut commensal microbiota and host immune system
The human gut commensal microbiota forms a complex population of microorganisms that survive by maintaining a symbiotic relationship with the host. Amongst the metabolic benefits it brings, formation of adaptive immune system and maintenance of its homeostasis are functions that play an important ro...
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| Format: | Article |
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Lithuanian University of Health Sciences
2015
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| Online Access: | https://eprints.nottingham.ac.uk/34650/ |
| _version_ | 1848794902918332416 |
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| author | Malys, Mantas Kazimieras Campbell, Laura Malys, Naglis |
| author_facet | Malys, Mantas Kazimieras Campbell, Laura Malys, Naglis |
| author_sort | Malys, Mantas Kazimieras |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The human gut commensal microbiota forms a complex population of microorganisms that survive by maintaining a symbiotic relationship with the host. Amongst the metabolic benefits it brings, formation of adaptive immune system and maintenance of its homeostasis are functions that play an important role. This review discusses the integral elements of commensal microbiota that stimulate responses of different parts of the immune system and lead to health or disease. It aims to establish conditions and factors that contribute to gut commensal microbiota's transformation from symbiotic to antibiotic relationship with human. We suggest that the host-microbiota relationship has been evolved to benefit both parties and any changes that may lead to disease, are not due to unfriendly properties of the gut microbiota but due to host genetics or environmental changes such as diet or infection. |
| first_indexed | 2025-11-14T19:23:35Z |
| format | Article |
| id | nottingham-34650 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:23:35Z |
| publishDate | 2015 |
| publisher | Lithuanian University of Health Sciences |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-346502020-05-04T17:04:16Z https://eprints.nottingham.ac.uk/34650/ Symbiotic and antibiotic interactions between gut commensal microbiota and host immune system Malys, Mantas Kazimieras Campbell, Laura Malys, Naglis The human gut commensal microbiota forms a complex population of microorganisms that survive by maintaining a symbiotic relationship with the host. Amongst the metabolic benefits it brings, formation of adaptive immune system and maintenance of its homeostasis are functions that play an important role. This review discusses the integral elements of commensal microbiota that stimulate responses of different parts of the immune system and lead to health or disease. It aims to establish conditions and factors that contribute to gut commensal microbiota's transformation from symbiotic to antibiotic relationship with human. We suggest that the host-microbiota relationship has been evolved to benefit both parties and any changes that may lead to disease, are not due to unfriendly properties of the gut microbiota but due to host genetics or environmental changes such as diet or infection. Lithuanian University of Health Sciences 2015-03-24 Article PeerReviewed Malys, Mantas Kazimieras, Campbell, Laura and Malys, Naglis (2015) Symbiotic and antibiotic interactions between gut commensal microbiota and host immune system. Medicina, 51 (2). pp. 69-75. ISSN 1010-660X Immune system; Commensal microbiota; T-cells; B-cells; Dysbiosis http://www.sciencedirect.com/science/article/pii/S1010660X15000245 doi:10.1016/j.medici.2015.03.001 doi:10.1016/j.medici.2015.03.001 |
| spellingShingle | Immune system; Commensal microbiota; T-cells; B-cells; Dysbiosis Malys, Mantas Kazimieras Campbell, Laura Malys, Naglis Symbiotic and antibiotic interactions between gut commensal microbiota and host immune system |
| title | Symbiotic and antibiotic interactions between gut commensal microbiota and host immune system |
| title_full | Symbiotic and antibiotic interactions between gut commensal microbiota and host immune system |
| title_fullStr | Symbiotic and antibiotic interactions between gut commensal microbiota and host immune system |
| title_full_unstemmed | Symbiotic and antibiotic interactions between gut commensal microbiota and host immune system |
| title_short | Symbiotic and antibiotic interactions between gut commensal microbiota and host immune system |
| title_sort | symbiotic and antibiotic interactions between gut commensal microbiota and host immune system |
| topic | Immune system; Commensal microbiota; T-cells; B-cells; Dysbiosis |
| url | https://eprints.nottingham.ac.uk/34650/ https://eprints.nottingham.ac.uk/34650/ https://eprints.nottingham.ac.uk/34650/ |